Hipoventilación central por gabapentina

Pérez, Raúl López; Lechuga, María Gámez; Álvarez, María Martínez-Lage; Albisu, Antonio Antón

doi:10.1016/s0025-7753(07)72643-x

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…If a clinician is planning to employ gabapentin for treating a drug-related problem, it is necessary to consider its potential side effects. A review of different studies describes side effects such as teratogenic effects (rodent studies), 45 – 47 central hypoventilation and/or respiratory failure, 48 , 49 deficits in visual field, 50 myopathy, 51 , 52 self-harm or suicidal behavior, 53 – 56 mitochondrial toxicity, 57 somnolence, dizziness and diarrhea; 58 however, other studies in nonhuman species 59 and human beings 60 did not find teratogenic effects (this topic is discussed further at the end of this section). Nevertheless, the studies that reported gabapentin induction of central hypoventilation were clinical studies with small sample sizes (n=1, a 74-year-old female, 48 and n=1, a 69-year-old male); 49 therefore, the reliability of these findings is discrete.…”

Section: Side Effects Caused By Gabapentinmentioning

confidence: 99%

Review about gabapentin misuse, interactions, contraindications and side effects

Quintero¹

2017

JEP

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The current work is targeted to review the risks of gabapentin misuse, its potential interactions with other drugs, side effects and use contraindications. This review consists of a total of 99 biographical references (from the year 1983 to 2016). A publication search of PubMed was performed from January 1983 to December 2016. It included animal studies, clinical studies, case studies and reviews related to gabapentin misuse, potential interactions, side effects and use contraindications. The search terms were gabapentin, anticonvulsant and antiepileptic. In general, it seems that gabapentin has risks of being misused based on the increased level of prescriptions, related fatalities, recreational misuse and higher doses of self-administration. The main reasons for gabapentin misuse are as follows: getting high, alleviating opioid withdrawal symptoms and potentiating methadone effects. Some of the main substances that interact with gabapentin are morphine, caffeine, losartan, ethacrynic acid, phenytoin, mefloquine and magnesium oxide. Some of the side effects caused by gabapentin are teratogenicity, hypoventilation, respiratory failure and myopathy. Finally, reports in general contraindicate the use of gabapentin in conditions such as myasthenia gravis and myoclonus.

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