Hiperglucemia secundaria a consumo de cocaína y antipsicóticos atípicos

Villaplana, Carlos R. Argente; Andrés, Miguel Civera; Collado, José Tomás Real; Martínez-Hervás, Sergio; Gimilio, Juan Francisco Ascaso; Rodríguez, Rafael Carmena

doi:10.1016/s1575-0922(08)72799-2

Cited by 2 publications

(1 citation statement)

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“…It is noteworthy that METH, conversely, inhibits glucose uptake in abusers and induces hypoglycemia [ 122 ]. COC, on the other hand, is recognized for its ability to raise plasma glucose levels by stimulating the release of catecholamines [ 123 ]. However, it is unclear whether a similar mechanism occurs in fish because, as demonstrated in zebrafish larvae, COC decreased dopamine plasma concentration [ 124 ].…”

Section: Bioaccumulation Of Illicit Drugs and Their Toxicitymentioning

confidence: 99%

Illicit Drugs in Surface Waters: How to Get Fish off the Addictive Hook

Falfushynska,

Rychter,

Boshtova

et al. 2024

Pharmaceuticals

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The United Nations World Drug Report published in 2022 alarmed that the global market of illicit drugs is steadily expanding in space and scale. Substances of abuse are usually perceived in the light of threats to human health and public security, while the environmental aspects of their use and subsequent emissions usually remain less explored. However, as with other human activities, drug production, trade, and consumption of drugs may leave their environmental mark. Therefore, this paper aims to review the occurrence of illicit drugs in surface waters and their bioaccumulation and toxicity in fish. Illicit drugs of different groups, i.e., psychostimulants (methamphetamines/amphetamines, cocaine, and its metabolite benzoylecgonine) and depressants (opioids: morphine, heroin, methadone, fentanyl), can reach the aquatic environment through wastewater discharge as they are often not entirely removed during wastewater treatment processes, resulting in their subsequent circulation in nanomolar concentrations, potentially affecting aquatic biota, including fish. Exposure to such xenobiotics can induce oxidative stress and dysfunction to mitochondrial and lysosomal function, distort locomotion activity by regulating the dopaminergic and glutamatergic systems, increase the predation risk, instigate neurological disorders, disbalance neurotransmission, and produce histopathological alterations in the brain and liver tissues, similar to those described in mammals. Hence, this drugs-related multidimensional harm to fish should be thoroughly investigated in line with environmental protection policies before it is too late. At the same time, selected fish species (e.g., Danio rerio, zebrafish) can be employed as models to study toxic and binge-like effects of psychoactive, illicit compounds.

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Section: Bioaccumulation Of Illicit Drugs and Their Toxicitymentioning

confidence: 99%