Hiperbilirubinemia pada neonatus &gt;35 minggu di Indonesia; pemeriksaan dan tatalaksana terkini

Rohsiswatmo, Rinawati; Amandito, Radhian

doi:10.14238/sp20.2.2018.115-22

Cited by 8 publications

(10 citation statements)

References 21 publications

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“…Aside from prematurity, genetic polymorphisms have been reported as an important factor in the development of SNNJ [4–6]. The most commonly-studied gene is the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) that is closely associated with Crigler-Najjar’s syndrome type I and II, and Gilberts syndrome.…”

Section: Introductionmentioning

confidence: 99%

SLCO1B1 c.388A > G variant incidence and the severity of hyperbilirubinemia in Indonesian neonates

et al. 2019

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Objective It has been established that genetic factors play a substantial role in the development of neonatal hyperbilirubinemia. The population of Indonesia and other Southeast Asian countries has similar, yet different genetic makeup compared to the rest of Asia. Aside from UGT1A1, variants of SLCO1B1 have also been known to contribute to the severity of neonatal hyperbilirubinemia in Asian populations. Since there has been no report on SLCO1B1 polymorphism in relation with hyperbilirubinemia in Indonesia, this study aims to explore incidence of SLCO1B1*1B polymorphism in Indonesia based on 3 hospitals from different provinces and population, and their association with hyperbilirubinemia severity. Methods Our study included 88 neonates with mild and moderate-severe hyperbilirubinemia from 3 NICU in hospitals representing homogenous and heterogenous populations: Biak General Hospital Papua, Cipto Mangunkusumo Hospital (Jakarta), and M Yunus Hospital (Bengkulu). We collected samples between November 2016 and September 2017. DNA was obtained from existing samples of the patients from previous studies and were subjected to Polymerase Chain Reaction – Restriction Fragment Length Polymorphism (PCR-RFLP). We analyzed the *1B variant located in exon 5 of SLCO1B1 with Taq I restriction endonuclease. Clinical, demographic, and laboratory data was also collected from medical records and parents’ interviews. Results The most dominant variant of SLCO1B1*1B in our population is the homozygous G/G (68.18%), followed by heterozygous A/G (26.14%), and wild type A/A (5.68%). The heterozygous A/G had an Odds Ratio (OR) of 0.73 (95% CI 0.10–5.2) and homozygous G/G with OR of 0.51 (95%CI 0.08–3.27), both were not significant. Genotypic distribution across the different centers were also similar and not significant. The significant risk factors for moderate-severe hyperbilirubinemia were the population the neonate originated from ( p = < 0.001) and the delivery location ( p = 0.001), while SLCO1B1*1B was not associated with the different severity of hyperbilirubinemia. Conclusions SLCO1B1*1B is not associated with higher bilirubin levels among neonates with hyperbilirubinemia in Indonesia. Further study is needed to find other potentially important genetic polymorphisms in the development of severe hyperbilirubinemia in Indonesia.

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Section: Introductionmentioning

confidence: 99%

SLCO1B1 c.388A > G variant incidence and the severity of hyperbilirubinemia in Indonesian neonates

et al. 2019

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“…Neonatal jaundice can occur in LBW either pre-term or term gestational age [17,23]. This occurs because the liver function is not optimal, there is a protein deficiency that plays a role in the transport of neonatal bilirubin, namely albumin and Y protein or ligandin, causing deposition of bilirubin in blood.…”

Section: Resultsmentioning

confidence: 99%

The Overview of Low Birth Weight Infants with Incidence of Neonatal Jaundice in Perinatology Ward at Dustira Hospital

Ayukarningsih¹,

Wahyudin²,

Pratiwi³

et al. 2021

Advances in Health Sciences Research

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Low Birth Weight (LBW) is an indicator of public health. The morbidity and mortality risk of LBW is 4 times greater than non-LBW. Low birth weight (LBW) both in pre term and term gestational age infants often occurs jaundice. This study aims to determine the distribution of LBW with neonatal jaundice based on gestational age in Perinatology Ward at Dustira Hospital. This quantitative descriptive study uses data sources from medical records in the Perinatology Ward from January to December 2019. The results of this study showed there were 51 (87.9%) pre-term LBW and 7 (12,1%) term LBW and none post-term LBW infant. There are 42 (72,8%) cases of LBW with neonatal jaundice with 35 (83,3%) pre-term LBW and 7 (16,7%) term LBW. Neonatal jaundice occurrs more often in pre-term LBW than term LBW as done by other studies. The incidence of LBW with neonatal jaundice is not only affected by gestational age, but also by ABO blood group incompatibility, maternal age during pregnancy, the gender of the infants, and asphyxia.

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“…Gross motor and fine motor skills Hyperbilirubinemia is an excess of bilirubin levels in the blood of more than 10 mg% in the first week which results in jaundice, a yellow color that is clearly visible in the skin, mucosa, sclera and urine, and other organs, whereas in normal infants the total serum bilirubin level is 5 mg% (Sembiring, 2019). Bilirubin levels will increase after birth, then settle and then decrease after the age of 7 days (Rohsiswatmo & Amandito, 2018). Pathologically the baby will experience jaundice throughout the body or grades three to five with bilirubin levels (> 12 mg/dl) this condition is indicated for phototherapy, if bilirubin levels are > 20 mg/dl then the baby is indicated for exchange transfusion.…”

Section: Introductionmentioning

confidence: 99%

“…There are as many as 6.6% of infants died in Indonesia due to neonatal jaundice (Kemenkes RI, 2015). As many as 3%-5% of neonates who have pathological hyperbilirubinemia are at high risk of developing kernicterus (Rohsiswatmo & Amandito, 2018). The incidence of jaundice in term infants in some hospitals is quite high, ranging from 13.7% to 85%.…”

Section: Introductionmentioning

confidence: 99%

Nursing Care of Neonatal Jaundice in Hyperbilirubinemia Babies: A Case Report

Tyas

Nurvianti

Mardhika

et al. 2021

JoViN

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Introduction: Jaundice is a condition that is often found in the 24 hours after the birth of the baby due to hyperbilirubinemia. Hyperbilirubinemia can cause various complications and death if not treated properly and immediately. The knowledge and ability of nurses in providing nursing care for neonatal jaundice still need to be improved. This study aims to describe nursing care for neonatal jaundice in hyperbilirubinemia infants. Methods: This study uses a case study approach design through the nursing process with a sample of a hyperbilirubinemia baby with neonatal jaundice nursing problems. Data collection techniques were carried out through interviews, observations, physical examinations and documentation studies. Data analysis in this study uses narrative analysis. Results: The case report found jaundice on the skin, sclera, and mucosa. The nursing diagnosis in this study was neonatal jaundice associated with less than 7 days of age. The intervention provided in the form of phototherapy and breastfeeding education showed the result was not found jaundice on the skin, sclera, and mucosa after three days. Conclusion: The provision of phototherapy and breastfeeding education is effective in solving neonatal jaundice.

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Hiperbilirubinemia pada neonatus >35 minggu di Indonesia; pemeriksaan dan tatalaksana terkini

Cited by 8 publications

References 21 publications

SLCO1B1 c.388A > G variant incidence and the severity of hyperbilirubinemia in Indonesian neonates

SLCO1B1 c.388A > G variant incidence and the severity of hyperbilirubinemia in Indonesian neonates

The Overview of Low Birth Weight Infants with Incidence of Neonatal Jaundice in Perinatology Ward at Dustira Hospital

Nursing Care of Neonatal Jaundice in Hyperbilirubinemia Babies: A Case Report

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