Hip / knee arthroplasty and risk of hip fracture: A population-based case-control study

Are people following hip and knee arthroplasty at greater risk of experiencing a fall and fracture? Data from the Osteoarthritis Initiative

“…Age and gender were reported as predictors of falls or fracture in the univariate analyses. Previously Lalmohamed et al [16] reported an association between TKA and increased hip fracture; however, this was not reproduced in this cohort, with contrary findings reported in this dataset. This may be attributed to the difference in ages where the mean age of the TKA cohort in our dataset was 68 years, compared to the increased age reported in Lalmohamed et al's [16] cohort who were ages 70 years and older.…”

“…Previously Lalmohamed et al [16] reported an association between TKA and increased hip fracture; however, this was not reproduced in this cohort, with contrary findings reported in this dataset. This may be attributed to the difference in ages where the mean age of the TKA cohort in our dataset was 68 years, compared to the increased age reported in Lalmohamed et al's [16] cohort who were ages 70 years and older. The findings of similar fracture rates between THA and TKA cohorts and age and gender matched cohorts reported in Prieto-Alhambra et al [17,23] but only at three year follow-up, though similar data from the UK General Practice Research Dataset reported by the same team concluded that risk was greater in the THA cohort up to five years post-operatively.…”

“…These results were lower than previous cohorts of 43% [12], but similar to Ikuotomo et al's [13] THA cohort of 36%, and higher than that reported by Swinkels and Allain [14] and Swinkels et al [15] at 23% and 24% respectively. Furthermore, previous cohorts have demonstrated a higher risk of hip fracture in people who undergo a TKA in the first 12 months, reported at 54% and 57% increased risk of hip fracture in Lalmohamed et al [16] and Prieto-Alhambra et al [17] respectively. In contrast, previous literature has demonstrated a significant improvement in gait and balance in those who have undergone THA and TKA to address these key physical risk factors to falling [18][19][20].…”

Oral Bisphosphonate Use and Total Knee/Hip Implant Survival: Validation of Results in an External Population‐Based Cohort

“…Kaplan‐Meier estimates were plotted to visualize the effect of bisphosphonate use on implant survival over time. The HR for revision rates according to duration of bisphosphonate use was illustrated using smoothing spline techniques (). HRs are accompanied by 95% confidence intervals (95% CIs).…”

Functional outcome and quality of life in patients with hip fracture after total knee arthroplasty

“…6 Both studies did report this significant finding among younger, more active patient groups but did not report similar findings in older patients -especially those aged 80 and above. 5,6 Hip fractures are associated with significant morbidity and mortality and, therefore, have been recognized to be a major public health concern worldwide. Like osteoarthritis and TKA, the incidence of hip fractures is expected to rise with an increasingly elderly population.…”