1998
DOI: 10.1001/archinte.158.9.990
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Hip Fracture Risk in Older White Men Is Associated With Change in Body Weight From Age 50 Years to Old Age

Abstract: Despite differences between older men and women in the incidence of and risk factors for hip fracture, weight history is also an important determinant of the risk of hip fracture among older men. Weight loss of 10% or more beginning at age 50 years increases the risk of hip fracture in older white men; weight gain of 10% or more decreases the risk of hip fracture. The relationship between extreme weight loss and poor health suggests that weight loss is a marker of frailty that may increase the risk of hip frac… Show more

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Cited by 90 publications
(80 citation statements)
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“…This result may appear conflicting with several observations, arising from epidemiological studies and suggesting that a high BMI is protective against fractures. 9,[34][35][36] In these studies, it was proposed that BMI could provide: (1) skeletal loading, which may cause a compensatory increase in bone mass, [34][35][36] and (2) padding that protects against fractures during falls. 9 We do not want to argue against these potential benefits from a high BMI.…”
Section: Discussionmentioning
confidence: 99%
“…This result may appear conflicting with several observations, arising from epidemiological studies and suggesting that a high BMI is protective against fractures. 9,[34][35][36] In these studies, it was proposed that BMI could provide: (1) skeletal loading, which may cause a compensatory increase in bone mass, [34][35][36] and (2) padding that protects against fractures during falls. 9 We do not want to argue against these potential benefits from a high BMI.…”
Section: Discussionmentioning
confidence: 99%
“…However, results from the few studies that included a post-weight loss follow-up suggest that alterations in BMD and bone turnover may persist during weight maintenance (Avenell et al, 1994;Fogelholm et al, 2001;Jensen et al, 2001;Hinton et al, 2010;Villareal et al, 2008). Consistent with these findings, observational data indicate that both weight loss and repeated cycles of weight loss and regain increase fracture risk in both men and women (Langlois et al, 1998(Langlois et al, , 2001Meyer et al, 1998;Bacon et al, 2004).…”
Section: Introductionmentioning
confidence: 94%
“…When energy requirements are not met owing to difficulties in self-feeding, poor mobility (Berkhout et al, 1998), dementia (Stewart et al, 2005) or reduced appetite (Mowe and Bohmer, 2002), body weight declines. Loss of body weight and muscle mass have been associated with risk of hip fracture (Patterson et al, 1992;Langlois et al, 1996Langlois et al, , 1998, reduced mobility (Bannerman et al, 2002;Schmid et al, 2003) and increased mortality (Dwyer et al, 1987;Ryan et al, 1995).…”
Section: Introductionmentioning
confidence: 99%