Himatanthus drasticus : a chemical and pharmacological review of this medicinal species, commonly found in the Brazilian Northeastern region

Almeida, Sheyla C X; Monteiro, Álefe Brito; G, Costa; Viana, Glauce Socorro de Barros

doi:10.1016/j.bjp.2017.10.002

Cited by 16 publications

(7 citation statements)

References 38 publications

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“…Free reactive species cause oxidative stress in various biomolecules and living tissues and are thus involved in a wide variety of human diseases such as rheumatoid arthritis, Alzheimer's, Parkinson's, amyotrophic lateral sclerosis, heart disease, various types of allergies, diabetes and numerous types of cancers ( Ahmadinejad et al, 2017). Thus, it is possible to observe that the phytochemical composition of H. obovatus latex has pharmacological potential, containing significant levels of phenolic compounds, flavonoids and tannins, which are important phytochemical groups with antioxidant activity, as is also observed for other Himatanthus species, H. articulatus, H. drasticus and H. sucuuba (Soares et al, 2016;Almeida et al, 2017).…”

Section: Resultsmentioning

confidence: 84%

“…Phytochemical compounds such as lupeol acetate and triterpenes found in H. obovatus, among other species of the genus Himatanthus, play important roles in the healing action and with anti-inflammatory activity in wounds (Santos et al, 2021). Another special group of phytomolecules found in H. drasticus and especially in H. obovatus are the iridoides, where their angiogenic, anti-inflammatory and antioxidant activities are already known, and which are also involved in cell increase and differentiation in healing processes (Soares et al, 2016;Almeida et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical and biological activities evaluation of latex from Himatanthus obovatus (Muell. Arg.) Woodson (Apocynaceae)

Ramada¹,

Filho

Ventura

et al. 2021

Sci. Elec. Arch.

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Himatanthus obovatus is a tree species that has laticifers in its aerial organs, where it is used in folk medicine. The aim of this work was to evaluate the latex of H. obovatus regarding its phytochemical composition and biological activities. The latex was collected and lyophilized, yield (%) was carried out, phytochemical prospection for several groups, determination of the content of flavonoids, phenolics and total tannins, antioxidant activity in reducing DPPH, antifungal activity on the Candida genus, antibacterial for Escherichia coli, Staphylococcus aureus, Salmonella serovar Enteritidis and Thyphymurium and Enterococcus faecalis, hemolytic activity on human erythrocytes and cytotoxicity bioassay on Artemia salina. The latex yield was 19.05%, positive presence of several groups of phytocompounds was observed, total flavonoid content of 78.80 mg QE 100 g-1, total phenolic compounds of 166.51 mg AGE g 100-1, total tannins of 14.81 mg TAE 100 g-1, antioxidant activity IC50 = 178.87 µg mL-1, antifungal activity for all Candida strains and antibacterial only for E. coli and E. faecalis, hemolytic activity between 68-18% and cytotoxicity with LC50 = 433.97 µg mL-1 on A. salina. The latex of Himatanthus obovatus demonstrated in this study, important phytochemical data and biological activities.

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Section: Resultsmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Phytochemical and biological activities evaluation of latex from Himatanthus obovatus (Muell. Arg.) Woodson (Apocynaceae)

Ramada¹,

Filho

Ventura

et al. 2021

Sci. Elec. Arch.

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“…Some compounds identified in the latex have been identified in other species of the Apocynaceae family, such as phenolic acid-like trans-4-coumaric acid and para-coumaric acid in Carissa carandus [ 12 ]. However, some of the tentative structures determined in the chromatographic analysis differed from other Himatanthus species, i.e., plumieride, an iridoid representative of this plant [ 13 ], lupeol, two isomers of amyrin, β-sitosterol, and proteins isolated from Himatanthus drasticus latex [ 5 ]. α-amyrin, lupeol, and lupeol acetate were also determined in the hexane fraction of H. sucuuba latex [ 14 ], and spirolactone iridoids such as plumericin and isoplumericin were identified in the ethanol extract of H. sucuuba stem bark [ 15 ].…”

Section: Resultsmentioning

confidence: 99%

“…Triterpenes, alkaloids, flavonoids, and iridoids are the most common chemical compounds found in its leaves, bark, and latex, and these have been shown to have anticancer, anti-inflammatory, and anthelmintic properties. Some species of the Himatanthus genus include H. drasticus , H. phagedaenicus , H. attenuatus, H. obovatus, H. semilunatus , H. tarapotensis , H. revolutus , H. articulatus , H. bracteatus , and H. sucuuba ( Figure 1 ) [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening of Himatanthus sucuuba (Spruce) Woodson (Apocynaceae) Latex, In Vitro Cytotoxicity and Incision Wound Repair in Mice

Herrera-Calderón

Calero-Armijos

Cardona‐G

et al. 2021

Plants

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Himatanthus sucuuba, also known as “Bellaco caspi”, is a medicinal plant whose latex, stem bark, and leaves possess phenolic acids, lupeol, β-dihydro-plumbericinic acid, plumericin, and plumeride, among other components. Some of these have been linked to such biological activities as antiulcer, anti-inflammatory, and wound healing. The aim of this study was to determine the phytochemical compounds of H. sucuuba latex, as well as its in vitro cytotoxicity and wound healing effect in mice. Latex was collected in the province of Iquitos, Peru. Phytochemical analysis was carried out with UPLC-ESI-MS/MS. The cytotoxicity was evaluated on two colon tumor cell lines (SW480 and SW620) and non-malignant cells (human keratinocytes, HaCaT, and Chinese hamster ovary, CHO-K1). The mice were distributed into two groups, as follows: Group I—control (n = 10; without treatment); II—(n = 10) H. sucuuba latex; wounds were induced with a scalpel in the dorsal–cervical area and treatments were applied topically twice a day on the incision for 10 days. Molecular docking was carried out on the glycogen synthase kinase 3β protein. Twenty-four chemical compounds were determined, mainly flavonoid-type compounds. Latex did not have a cytotoxic effect on tumor cells with IC50 values of more than 500 µg/mL. The latex had a regenerative effect on wounds in mice. Acacetin-7-O-neohesperidoside had the best docking score of -9.9 kcal/mol. In conclusion, H. sucuuba latex had a wound healing effect in mice, as confirmed by histological study. However, a non-cytotoxic effect was observed on colon tumor cells SW480 and SW620.

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“…An antitumor activity was observed against sarcomas in tests using the leaf extract (SOUSA et al 2010), however, no influence was observed against lung cancers in tests using the latex (FRANCE et al 2011). Moreover, a gastroprotective effect for the latex was observed in mice (COLARES et al 2008) and an anti-inflammatory effect has also been verified (ALMEIDA et al 2017).…”

Section: Species Versatilitymentioning

confidence: 94%

Bioprospecção De Fungos Amazônicos Produtores De L-Asparaginase Extracelular

Costa¹

2020

Ciências Biológicas: Realidades E Virtualidades

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Direitos para esta edição cedidos à Atena Editora pelos autores. Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais. A Atena Editora não se responsabiliza por eventuais mudanças ocorridas nos endereços convencionais ou eletrônicos citados nesta obra. Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação.

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Himatanthus drasticus : a chemical and pharmacological review of this medicinal species, commonly found in the Brazilian Northeastern region

Cited by 16 publications

References 38 publications

Phytochemical and biological activities evaluation of latex from Himatanthus obovatus (Muell. Arg.) Woodson (Apocynaceae)

Phytochemical and biological activities evaluation of latex from Himatanthus obovatus (Muell. Arg.) Woodson (Apocynaceae)

Phytochemical Screening of Himatanthus sucuuba (Spruce) Woodson (Apocynaceae) Latex, In Vitro Cytotoxicity and Incision Wound Repair in Mice

Bioprospecção De Fungos Amazônicos Produtores De L-Asparaginase Extracelular

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