Higuchi equation: Derivation, applications, use and misuse

Siepmann, J.; Peppas, Nicholas A.

doi:10.1016/j.ijpharm.2011.03.051

Cited by 766 publications

(477 citation statements)

References 35 publications

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“…Drug release will be proceeded by the dissolution of the existing drug on the surface of the system and follow by swelling matrix polymer. The drug in the deeper parts will come out of the system when the drug on the surface had separated, so the concentration increases [35]. The release profile of NA from NA-CS, NA-CMC-D1, and NA-CMC-D3 with respect to time can be shown in Table 2 and Fig.…”

Section: Encapsulation Efficiency and Nicotinamide Releasementioning

confidence: 99%

“…It indicates that drug release mechanism is not only influenced by the drug diffusion process, but also degradation of the polymeric matrix. Based on these models can be estimated that the release process through 2 steps, (i) drug release fully caused by drug diffusion and (ii) the degradation of polymer matrix [35]. Determination of drug release of all samples was done in a longer time that is 12 hours to know the stability of the system as depicted in Table 3 and Fig.…”

Section: Encapsulation Efficiency and Nicotinamide Releasementioning

confidence: 99%

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The Optimum Conditions of Carboxymethyl Chitosan Synthesis on Drug Delivery Application and Its Release of Kinetics Study

Siahaan

Mentari²,

Wiedyanto³

et al. 2017

Indones. J. Chem.

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Section: Encapsulation Efficiency and Nicotinamide Releasementioning

confidence: 99%

Section: Encapsulation Efficiency and Nicotinamide Releasementioning

confidence: 99%

The Optimum Conditions of Carboxymethyl Chitosan Synthesis on Drug Delivery Application and Its Release of Kinetics Study

Siahaan

Mentari²,

Wiedyanto³

et al. 2017

Indones. J. Chem.

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“…The outcome of fitting (Table 2) showed that only the s-C-15h provided an excellent goodness of fit (R 2 > 0.95) and the n parameter indicated an anomalous (non-Fickian) transport (0.45 < n < 1.00) [51,52]. In contrast, s-C-1h gave a good goodness of fit (0.90 < R 2 < 0.95) but did not allow for drawing any conclusion on the limiting mechanism of release as the parameter (n) did not correspond to any known range according to the KP assumptions.…”

Section: Drug Releasementioning

confidence: 99%

Changes in the drug release pattern of fresh and set simvastatin-loaded brushite cement

Mestres

Kugiejko

Pastorino

et al. 2016

Materials Science and Engineering: C

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Calcium phosphate cements are synthetic bone graft substitutes able to set at physiological conditions. They can be applied by minimally invasive surgery and can also be used as drug delivery systems.Consequently, the drug release pattern from the cement paste (fresh cement) is of high clinical interest.However, previous studies have commonly evaluated the drug release using pre-set cements only.Therefore, the aim of this work was to determine if the time elapsed from cement preparation until immersion in the solution (3 min for fresh cements, and 1 h and 15 h for pre-set cements) had an influence on its physical properties, and correlating these to the drug release profile. Simvastatin was selected as a model drug, while brushite cement was used as drug carrier. This study quantified how the setting of a material reduces the accessibility of the release media to the material, thus preventing drug release. A shift in the drug release pattern was observed, from a burst-release for fresh cements to a sustained release for pre-set cements.

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“…However, it is unlikely that there will be one mathematical model that will be able to describe any type of release of ions or molecules from biomaterials. It is much more likely that there will be different mathematical models, applicable to specific types of systems that differ in geometry and composition (Arifin et al 2006;Brazel and Peppas 2000;Dash et al 2010;Fredenberg et al 2011;Frenning 2003;Frenning et al 2005;Frenning and Strømme 2003;Polakovič et al 1999;Siepmann and Peppas 2011;Siepmann and Siepmann 2008). Over the past few years, a few lattice-based three-dimensional (3D) mathematical models have been proposed to study the in vivo bone formation process in porous biodegradable CaP scaffolds (Adachi et al 2006;Byrne et al 2007;Sun et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Computational modelling of local calcium ions release from calcium phosphate-based scaffolds

Manhas

Guyot

Kerckhofs

et al. 2016

Biomech Model Mechanobiol

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A variety of natural or synthetic calcium phosphate (CaP)-based scaffolds are currently produced for dental and orthopaedic applications. These scaffolds have been shown to stimulate bone formation due to their biocompatibility, osteoconductivity and osteoinductivity. The release of the Ca 2+ ions from these scaffolds is of great interest in light of the aforementioned properties. It can depend on a number of biophysicochemical phenomena such as dissolution, diffusion and degradation, which in turn depend on specific scaffold characteristics such as composition and morphology. Achieving an optimal release profile can be challenging when relying on traditional experimental work alone. Mathematical modelling can complement experimentation. In this study, the in vitro dissolution behaviour of four CaP-based scaffold types was investigated experimentally. Subsequently, a mechanistic finite element method model based on biophysicochemical phenomena and specific scaffold characteristics was developed to predict the experimentally observed behaviour. Before the model could be used for local Ca 2+ ions release predictions, certain parameters such as dissolution constant (k dc ) and degradation constant (k sc ) for each type of scaffold were determined by calibrating the model to the in vitro dissolution data. The resulting model showed to yield release characteristics in satisfactory agreement with those observed experimentally. This suggests that the mathematical model can be used to investigate the local Ca 2+ ions release from CaP-based scaffolds.

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Higuchi equation: Derivation, applications, use and misuse

Cited by 766 publications

References 35 publications

The Optimum Conditions of Carboxymethyl Chitosan Synthesis on Drug Delivery Application and Its Release of Kinetics Study

The Optimum Conditions of Carboxymethyl Chitosan Synthesis on Drug Delivery Application and Its Release of Kinetics Study

Changes in the drug release pattern of fresh and set simvastatin-loaded brushite cement

Computational modelling of local calcium ions release from calcium phosphate-based scaffolds

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