The Optimum Conditions of Carboxymethyl Chitosan Synthesis on Drug Delivery Application and Its Release of Kinetics Study

Siahaan, Parsaoran; Mentari, Nadira Cahyaning; Wiedyanto, Ustera Octovindra; Hudiyanti, Dwi; Hildayani, Suci Zulaikha; Laksitorini, Marlyn Dian

doi:10.22146/ijc.24252

Cited by 23 publications

(9 citation statements)

References 32 publications

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“…This causes the hydrated water molecules that around the chain of CMCH are more than that surrounding the chitosan chains, resulting in higher water solubility [ 30 ]. This results also are consistent with the report of Siahaan et al [ 31 ] who found that the temperature and NaOH concentration affected to CMCH synthesis. The interactions between NaOH and monochloroacetic acid resulted in reduced CMCH forming and lower solubility.…”

Section: Resultssupporting

confidence: 93%

Antioxidant and Moisturizing Properties of Carboxymethyl Chitosan with Different Molecular Weights

et al. 2020

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This research aimed to synthesize carboxymethyl chitosan (CMCH) from different molecular weights of chitosan including low MW (L, 50–190 kDa), medium MW (M, 210–300 kDa) and high MW (H, 310–375 kDa) on the antioxidant and moisturizing properties. The L-CMCH, M-CMCH and H-CMCH improved the water solubility by about 96%, 90% and 89%, respectively when compared to native chitosan. Higher MW resulted in more viscous of CMCH. For antioxidant properties, IC50 values of DPPH and ABTS radical scavenging activity for L-CMCH were 1.70 and 1.37 mg/mL, respectively. The L-CMCH had higher antioxidant properties by DPPH and ABTS radical scavenging assay and FRAP. The moisturizing properties on pig skin using a Corneometer® showed that 0.5% H-CMCH significantly presented (p ≤ 0.05) greater moisturizing effect than that of untreated-skin, distilled water, propylene glycol and pure chitosan from three molecular weights.

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Section: Resultssupporting

confidence: 93%

Antioxidant and Moisturizing Properties of Carboxymethyl Chitosan with Different Molecular Weights

et al. 2020

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“…GO can interact with CMCS and PVA by hydrogen bonding. Thus, GO could act as crosslinker and increase rigidity of both first (CMCS) and second hydrogel (PVA) . The enhanced rigidity resulted in improved tensile strength and modulus.…”

Section: Resultsmentioning

confidence: 99%

Both Tough and Soft Double Network Hydrogel Nanocomposite Based on O‐Carboxymethyl Chitosan/Poly(vinyl alcohol) and Graphene Oxide: A Promising Alternative for Tissue Engineering

Pourjavadi

Tehrani

Salami³

et al. 2020

Polymer Engineering & Sci

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A reinforced double network (DN) hydrogel as a candidate for skin scaffold was prepared. It consists of Ocarboxymethyl chitosan, polyvinyl alcohol, honey, CaCl 2 , and graphene oxide. The various concentrations of CaCl 2 , namely, 30, 45, and 60 wt% were investigated. Besides, the GO content was studied as 3, 5, and 10 wt%. The structure of the DN was characterized by Fourier-transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry, X-ray diffraction, energy dispersive X-ray and Brunauer-Emmett-Teller were evaluated. The mechanical properties were studied, too. It showed that the DN with 45 wt% CaCl 2 was optimized. Also, swelling mechanism was investigated. Moreover, with the increase in GO content, the mechanical strength was increased. The cytotoxicity was evaluated and it was indicated that DN with 45% CaCl 2 and 5% GO had an acceptable level of biocompatibility. Moreover, scanning electron microscopy images showed the porous structure of the DN nanocomposite. Thus, the DN has the potential to be applied in tissue engineering as a skin scaffold. POLYM. ENG. SCI., 60:889-899, 2020.

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“…We selected CMC instead of a virgin chitosan, which is one of the most studied polysaccharides nowadays with a wide number of applications in pharmacology and medicine, because a Folin-Ciocalteu's test with pristine chitosan gives a positive detection result, making it unfavorable for the presence study. Furthermore, it has been reported that CMC efficiency in drug carrier formulation is higher than with the unmodified chitosan 34 . Besides, by introducing the carboxymethyl hydrophilic groups to the chitosan structure, the CMC polymer becomes water soluble.…”

Section: Resultsmentioning

confidence: 99%

Stability and anti-proliferative properties of biologically active compounds extracted from Cistus L. after sterilization treatments

Ammendola

Haponska

Balik

et al. 2020

Sci Rep

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The growing interest of oncologists in natural compounds such as polyphenols and flavonoids is encouraging the development of innovative and efficient carriers for the delivery of those drugs. This study examines carboxymethyl chitosan-based microcapsules created by spray drying as a method for delivering biologically active compounds isolated from the Cistus herb. Effects of sterilization and encapsulation on the polyphenol and flavonoid content of Cistus extract were investigated to optimize the production process. Furthermore, in vitro studies were carried out to examine the anticancer properties of sterilized polyphenols and flavonoids on glioblastoma cells isolated from oncological patients. Acquired results show high anticancer potential towards glioblastoma as well as low cytotoxicity towards non-cancer cell lines by the substances in question. Steam sterilization is shown to affect the content of biologically active compounds the least. We demonstrate that the investigated form of drug encapsulation is both efficient and potentially possible to scale up from the viewpoint of the pharmaceutical industry. According to apress statement launched by the International Agency for Research on Cancer from the World Health Organization (WHO), in 2018the global cancer burdenaffected 18.1 million new cases and 9.6 million of people passed away. Ten in 50 men and one in 60 women worldwide suffer from cancer during their life, and ten in 80 men and eleven in 110 women posse awaydue to thisillness. Moreover, cancer is a most frequent causeof children death. Worldwide, every year, approximately 300.000 of children are diagnosed by oncologists with a cancer disease 1,2. Furthermore, according to the published statistic data, the total number of people who are alive within 5 years of a cancer diagnosis, called the 5-year prevalence, is arround 43.8 million 3. As stated in the WHO report,the frequent types of cancer in men are cancer of lung, prostate, colorectal, stomach and liver, while in case on women, the most common type of cancer are: breast, colorectal, lung, cervix and thyroid cancer. The uncontrollable growth of tumor cells is the most fundamental aspect of cancer 4. Even if available therapies such as surgery, immunotherapy, chemotherapy, targeted therapy, hormone therapy and radiation therapy play a significant role in cancer treatment, drug resistance and toxicity remain main problems and challenges to cure cancer patients 5. Oncologists have called for basic investigationsand new upstream technologieswhich insustainably, efficiently and safely way will meet the current and future patients' needs 6,7. Additionally, during the last years the "integrative" oncology society has demanded advancesfrom scientists on the development of natural medicals 8,9. Indeed, the anticancer effects of biologically active compounds, such as natural polyphenols synthesized by fruits, vegetables, teas, apples, cocoa and other plants, have become a hot topic in many laboratories 10-12 .

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The Optimum Conditions of Carboxymethyl Chitosan Synthesis on Drug Delivery Application and Its Release of Kinetics Study

Abstract: In this paper, carboxymethyl chitosan (CMC) was synthesized and studied as a carrier to encapsulate vitamin (as drug model) and controlled release. Chitosan (CS) is a polycationic derivated from chitin

Cited by 23 publications

References 32 publications

Antioxidant and Moisturizing Properties of Carboxymethyl Chitosan with Different Molecular Weights

Antioxidant and Moisturizing Properties of Carboxymethyl Chitosan with Different Molecular Weights

Both Tough and Soft Double Network Hydrogel Nanocomposite Based on O‐Carboxymethyl Chitosan/Poly(vinyl alcohol) and Graphene Oxide: A Promising Alternative for Tissue Engineering

Stability and anti-proliferative properties of biologically active compounds extracted from Cistus L. after sterilization treatments

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