Highly water-soluble magnetic iron oxide (Fe3O4) nanoparticles for drug delivery: enhanced in vitro therapeutic efficacy of doxorubicin and MION conjugates

Majeed, Muhammad Irfan; Lu, Qunwei; Wang, Yan; Li, Zhen; Hussain, Irshad; Tahir, Muhammad Nawaz; Tremel, Wolfgang; Tan, Bien

doi:10.1039/c3tb20322k

Cited by 98 publications

(60 citation statements)

References 48 publications

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“…Iron oxide-based magnetic nanoparticles are widely investigated because of their tunable magnetic properties and potentials in nanomedicine like targeted drug delivery [1,2], diagnostics with MRI bioimaging [3,4], and magnetic hyperthermia [5,6]. Numerous works described their therapeutic efficacy after conjugation with various drugs and biomolecules [7]. Nanosized superparamagnetic Fe 3 O 4 nanoparticles (SPIONs) offer large surface-to-volume ratio, high surface area, easiness of modification by antitumor drugs, low toxicity, and enormous potential in targeted drug delivery and magnetic hyperthermia [8].…”

Section: Introductionmentioning

confidence: 99%

Lanthanide-Doped SPIONs Bioconjugation with Trastuzumab for Potential Multimodal Anticancer Activity and Magnetic Hyperthermia

et al. 2020

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Iron oxide-based nanoparticles have been modified in their core with holmium(III) in an amount affecting only slightly their magnetic properties. Nanoparticles were conjugated covalently with biomolecule of trastuzumab (Herceptin®), the monoclonal antibody that recognizes cancer cells overexpressing HER2 receptors targeting such nanoparticles to the specified tumor tissues. Systematic studies of Ho3+-doped bioconjugates were carried out as a preliminary step for future replacement of ‘cold’ Ho with 166Ho radionuclide, emitting ‘soft’ beta(-) radiation for possible targeted radionuclide therapy. Physicochemical properties of the obtained bioconjugates were subsequently tested for use in magnetic hyperthermia, considered as an effective, low-invasiveness anticancer therapy. With such a system we expect to achieve both: active targeting and multimodal action by simultaneous internal and localized irradiation and magnetic hyperthermia of specific cancers.

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Section: Introductionmentioning

confidence: 99%

Lanthanide-Doped SPIONs Bioconjugation with Trastuzumab for Potential Multimodal Anticancer Activity and Magnetic Hyperthermia

et al. 2020

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“…The saturation magnetization (δ s ) of the Fe 3 O 4 NPs and MNHG were determined to be about 86.3 and 52.4 emug −1 , respectively. In comparison with similar systems, the developed MNHG exhibited higher magnetization value that qualified it for targeted drug delivery …”

Section: Resultsmentioning

confidence: 91%

Synthesis and characterization of a novel stimuli‐responsive magnetite nanohydrogel based on poly(ethylene glycol) and poly(N‐isopropylacrylamide) as drug carrier

Mozaffari

Hatamzadeh

Massoumi

et al. 2018

J of Applied Polymer Sci

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A novel stimuli‐responsive magnetite nanohydrogel (MNHG), namely [poly(ethylene glycol)‐block‐poly(N‐isopropylacrylamide‐co‐maleic anhydride)2]‐graft‐poly(ethylene glycol)/Fe3O4 [PEG‐b‐(PNIPAAm‐co‐PMA)2]‐g‐PEG/Fe3O4, was successfully developed. For this purpose, NIPAAm and MA monomers were block copolymerized onto PEG‐based macroinitiator through atom transfer radical polymerization technique to produce PEG‐b‐(PNIPAAm‐co‐PMA)2. The synthesized Y‐shaped terpolymer was crosslinked through the esterification of maleic anhydride units using PEG chains to afford a hydrogel. Afterward, magnetite nanoparticles were incorporated into the synthesized hydrogel through the physical interactions. The chemical structures of all synthesized samples were characterized using Fourier transform infrared and proton nuclear magnetic resonance spectroscopies. Morphology, thermal stability, size, and magnetic properties of the synthesized MNHG were investigated. In addition, the doxorubicin hydrochloride loading and encapsulation efficiencies as well as stimuli‐responsive drug release ability of the synthesized MNHG were also evaluated. The drug‐loaded MNHG at physiological condition exhibited negligible drug release values. In contrast, at acidic (pH 5.3) condition and a little bit higher temperature (41 °C) the developed MNHG showed higher drug release values, which qualified it for cancer chemotherapy due to especial physiology of cancerous tissue in comparison with the surrounding normal tissue. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46657.

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“…It is often used for the modification of inorganic nanoparticles materials with carboxyl (-COOH) group and amino class (NH 2 ) molecules, such as oleic acid and polylactic acid and polyethyleneimine [4]. Recently, many efforts have been made to develop stimuli-triggered drug delivery systems that can regulate the release of the loaded drug effectively in response to a given stimulus, such as pH change [5], temperature change [6], redox activation [7], enzymatic activity [8] and competitive binding [9,10], thereby minimizing the systemic side effects of the drugs.…”

Section: Introductionmentioning

confidence: 99%

Glycine-functionalized Fe₃O₄@TiO₂:Er³⁺,Yb³⁺nanocarrier for microwave-triggered controllable drug release and study on mechanism of loading/release process using microcalorimetry

Peng¹,

Cui²,

Zhao³

et al. 2015

Expert Opinion on Drug Delivery

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Highly water-soluble magnetic iron oxide (Fe3O4) nanoparticles for drug delivery: enhanced in vitro therapeutic efficacy of doxorubicin and MION conjugates

Cited by 98 publications

References 48 publications

Lanthanide-Doped SPIONs Bioconjugation with Trastuzumab for Potential Multimodal Anticancer Activity and Magnetic Hyperthermia

Lanthanide-Doped SPIONs Bioconjugation with Trastuzumab for Potential Multimodal Anticancer Activity and Magnetic Hyperthermia

Synthesis and characterization of a novel stimuli‐responsive magnetite nanohydrogel based on poly(ethylene glycol) and poly(N‐isopropylacrylamide) as drug carrier

Glycine-functionalized Fe₃O₄@TiO₂:Er³⁺,Yb³⁺nanocarrier for microwave-triggered controllable drug release and study on mechanism of loading/release process using microcalorimetry

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Highly water-soluble magnetic iron oxide (Fe3O4) nanoparticles for drug delivery: enhanced in vitro therapeutic efficacy of doxorubicin and MION conjugates

Cited by 98 publications

References 48 publications

Lanthanide-Doped SPIONs Bioconjugation with Trastuzumab for Potential Multimodal Anticancer Activity and Magnetic Hyperthermia

Lanthanide-Doped SPIONs Bioconjugation with Trastuzumab for Potential Multimodal Anticancer Activity and Magnetic Hyperthermia

Synthesis and characterization of a novel stimuli‐responsive magnetite nanohydrogel based on poly(ethylene glycol) and poly(N‐isopropylacrylamide) as drug carrier

Glycine-functionalized Fe3O4@TiO2:Er3+,Yb3+nanocarrier for microwave-triggered controllable drug release and study on mechanism of loading/release process using microcalorimetry

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Glycine-functionalized Fe₃O₄@TiO₂:Er³⁺,Yb³⁺nanocarrier for microwave-triggered controllable drug release and study on mechanism of loading/release process using microcalorimetry