Highly swelling pH-responsive microgels for dual mode near infra-red fluorescence reporting and imaging

Zhu, Mingning; Lu, Dongdong; Lian, Qing; Wu, Shang-Lin; Wang, Wenkai; Lyon, L. Andrew; Wang, Weiguang; Bártolo, Paulo; Dickinson, Mark; Saunders, Brian R.

doi:10.1039/d0na00581a

Cited by 9 publications

(5 citation statements)

References 83 publications

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“…By switching between charged and uncharged states depending on the solution pH, these monomers govern the microgel's swelling by promoting electrostatic repulsion among the chains and forming hydrogen bonds with water. [142][143][144][145] For example, Li et al sandwiched AA-containing microgels between thin films and utilized the pH-induced microgel swelling to vary the distance between the films. [33] Giraud et al explored the effects of charge and inter-particle spacing on the sliding friction between sheets of pH-responsive P(S-co-AA) microgels.…”

Section: Ph-responsive Monomersmentioning

confidence: 99%

Surface‐Bound Microgels for Separation, Sensing, and Biomedical Applications

Cutright

Harris

Ramesh

et al. 2021

Adv Funct Materials

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This study presents a comprehensive survey of microgel-coated materials and their functional behavior, describing the complex interplay between the physicochemical and mechanical properties of the microgels and the chemical and morphological features of substrates. The cited literature is articulated in four main sections: i) properties of 2D and 3D substrates, ii) synthesis, modification, and characterization of the microgels, iii) deposition techniques and surface patterning, and iv) application of microgel-coated surfaces focusing on separations, sensing, and biomedical applications. Each section discussesby way of principles and examples -how the various design parameters work in concert to deliver functionality to the composite systems. The case studies presented herein are viewed through a multi-scale lens. At the molecular level, the surface chemistry and the monomer make-up of the microgels endow responsiveness to environmental and artificial physical and chemical cues. At the micro-scale, the response effects shifts in size, mechanical, and optical properties, and affinity towards species in the surrounding liquid medium, ranging from small molecules to cells. These phenomena culminate at the macro-scale in measurable, reversible, and reproducible effects, aiming in a myriad of directions, from lab-scale to industrial applications.

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Section: Ph-responsive Monomersmentioning

confidence: 99%

Surface‐Bound Microgels for Separation, Sensing, and Biomedical Applications

Cutright

Harris

Ramesh

et al. 2021

Adv Funct Materials

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show abstract

“…The smart, adaptive microgels have high potential in various fields for applications in catalysis (8,9), in uptake and release (10), in tissue engineering (11,12), as sensors (13,14), for advanced bioimaging (15), as photonic materials (16,17), in extraction processes (18), as responsive membranes (19,20), and as antifouling surface coatings (21). Apart from the numerous medical and technical applications, responsive microgels are also powerful materials to investigate basic physics in colloidal matter (22,23).…”

Section: Introductionmentioning

confidence: 99%

3D Super-Resolution Fluorescence Imaging of Microgels

Nevskyi

Wöll

2023

Annu. Rev. Phys. Chem.

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Super-resolution fluorescence microscopy techniques are powerful tools to investigate polymer systems. In this review, we address how these techniques have been applied to hydrogel nano- and microparticles, so-called nano- or microgels. We outline which research questions on microgels could be addressed and what new insights could be achieved. Studies of the morphology, shape, and deformation of microgels; their internal compartmentalization; the cross-linker distribution and polarity inside them; and their dynamics and diffusion are summarized. In particular, the abilities to super-resolve structures in three dimensions have boosted the research field and have also allowed researchers to obtain impressive 3D images of deformed microgels. Accessing information beyond 3D localization, such as spectral and lifetime properties and correlative imaging or the combination of data with other methods, shines new light onto polymer systems and helps us understand their complexity in detail. Such future trends and developments are also addressed. Expected final online publication date for the Annual Review of Physical Chemistry, Volume 74 is April 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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“…[ 20 ] The degree of functional complexity in these materials can be tailored by coassembling different species of functional microgels, which exhibit stimuli‐responsive behavior to temperature [ 21 ] or pH changes. [ 22 ] Yet, for high‐resolution fabrication of such hydrogel material assemblies with control on a single‐particle level, one would require narrowing the output flow of microgels, e.g., the nozzle of a microfluidic device or extrusion‐based bioprinter, which is challenging due to dominant clogging.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Thermoresponsive and Multimaterial Hydrogel Sheets by Spatially Controlled Aspiration and Interconnection of Microgel Building Blocks

Weigel,

Grigoryev,

Fertala

et al. 2023

Adv Materials Technologies

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Polymer materials made from hierarchically assembled building blocks form a promising material class for engineering complex systems with integrated functionality for biological or electronic applications. Herein, this work utilizes an aspiration‐based process involving a hole‐bearing glass plate to align and interconnect acrylamide‐ and N‐isopropylacrylamide‐based microgels fabricated via emulsion formation in 3D‐printed microfluidics. By tuning hole diameter and inter‐hole distance as well as microgel deformability, mechanically stable, freestanding microgel constructs are obtained, which withstand shaking, ultrasonication, and swelling–shrinking cycles. By segmentally controlling aspiration at the hole‐bearing glass plate, freestanding multimaterial sheets consisting of two different microgel species are obtained. The microgel assembly process is the first step toward fabricating hydrogel‐based materials with spatially controlled functionality, which is an essential step toward system integration in polymer materials.

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Highly swelling pH-responsive microgels for dual mode near infra-red fluorescence reporting and imaging

Abstract: Near infra-red (NIR) fluorescence is a desirable property for probe particles because such deeply penetrating light enables remote reporting of the local environment in complex surroundings and imaging. Here, two...

Cited by 9 publications

References 83 publications

Surface‐Bound Microgels for Separation, Sensing, and Biomedical Applications

Surface‐Bound Microgels for Separation, Sensing, and Biomedical Applications

3D Super-Resolution Fluorescence Imaging of Microgels

Fabrication of Thermoresponsive and Multimaterial Hydrogel Sheets by Spatially Controlled Aspiration and Interconnection of Microgel Building Blocks

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