Highly stable carbon nanotube doped poly(3,4-ethylenedioxythiophene) for chronic neural stimulation

Liu, Xiang; Weaver, Cassandra L.; Zhou, Daojin; Greenberg, Robert J.; Cui, Xinyan Tracy

doi:10.1016/j.biomaterials.2011.04.051

Cited by 230 publications

(242 citation statements)

References 52 publications

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“…Specifically, the charge capacity of the MWCNT scaffold was 2.21 ± 0.12 mC cm −2 , a value significantly higher than that of bare the PEGDA scaffold (0.133 ± 0.09 mC cm −2 ). This result indicates that the MWCNT scaffolds can deliver higher charge densities without generating high voltage that may harm surrounding tissues [31]. Figure 4(A) shows the water contact angle on the surface of various 3D printed scaffolds with or without MWCNTs.…”

Section: Discussionmentioning

confidence: 93%

3D printing nano conductive multi-walled carbon nanotube scaffolds for nerve regeneration

et al. 2018

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Objective. Nanomaterials, such as carbon nanotubes (CNTs), have been introduced to modify the surface properties of scaffolds, thus enhancing the interaction between the neural cells and biomaterials. In addition to superior electrical conductivity, CNTs can provide nanoscale structures similar to those present in the natural neural environment. The primary objective of this study is to investigate the proliferative capability and differential potential of neural stem cells (NSCs) seeded on a CNT incorporated scaffold. Approach. Amine functionalized multi-walled carbon nanotubes (MWCNTs) were incorporated with a PEGDA polymer to provide enhanced electrical properties as well as nanofeatures on the surface of the scaffold. A stereolithography 3D printer was employed to fabricate a well-dispersed MWCNT-hydrogel composite neural scaffold with a tunable porous structure. 3D printing allows easy fabrication of complex 3D scaffolds with extremely intricate microarchitectures and controlled porosity. Main results. Our results showed that MWCNT-incorporated scaffolds promoted neural stem cell proliferation and early neuronal differentiation when compared to those scaffolds without the MWCNTs. Furthermore, biphasic pulse stimulation with 500 µA current promoted neuronal maturity quantified through protein expression analysis by quantitative polymerase chain reaction. Significance. Results of this study demonstrated that an electroconductive MWCNT scaffold, coupled with electrical stimulation, may have a synergistic effect on promoting neurite outgrowth for therapeutic application in nerve regeneration.

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Section: Discussionmentioning

confidence: 93%

3D printing nano conductive multi-walled carbon nanotube scaffolds for nerve regeneration

et al. 2018

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“…Xiliang Luo and Xinyan T. Cui et al of University of Pittsburgh doped acidified carbon nanotube (CNT) as negatively charged counter ion separately into PEDOT to form PEDOT/CNT composite as electrode-tissue interface [62]. As exhibited in Figure 7c, the PEDOT/CNT composite exhibited rougher surface than other PEDOT electrode-tissue interface, which facilitated the improvement of electrochemical performance though increasing effective area.…”

Section: Electrode-tissue Interface For Neural Interfacementioning

confidence: 84%

“…For instance, mechanically strong macromolecules have the ability to enhance the stability of conducting polymer composites [58]. Similarly, nano-materials with excellent conductivity, such as carbon nanotubes, are capable of improving the electrical performance of composite film [59].…”

Section: Electrode-tissue Interface For Neural Interfacementioning

confidence: 99%

Progress in Research of Flexible MEMS Microelectrodes for Neural Interface

Tang¹,

Tian²,

Kang³

et al. 2017

Preprint

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Abstract:With the rapid development of MEMS (Micro-electro-mechanical Systems) fabrication technologies, manifolds microelectrodes with various structures and functions have been designed and fabricated for applications in biomedical research, diagnosis and treatment through electrical stimulation and electrophysiological signal recording. The flexible MEMS microelectrodes exhibit multi-aspect excellent characteristics beyond stiff microelectrodes based on silicon or SU-8, which comprising: lighter weight, smaller volume, better conforming to neural tissue and lower fabrication cost. In this paper, we mainly reviewed key technologies on flexible MEMS microelectrodes for neural interface in recent years, including: design and fabrication technology, flexible MEMS microelectrodes with fluidic channels and electrode-tissue interface modification technology for performance improvement. Furthermore, the future directions of flexible MEMS microelectrodes for neural interface were described including transparent and stretchable microelectrodes integrated with multi-aspect functions and next-generation electrode-tissue interface modifications facilitated electrode efficacy and safety during implantation. Finally, the combinations among micro fabrication techniques with biomedical engineering and nanotechnology represented by flexible MEMS microelectrodes for neural interface will open a new gate to human lives and understanding of the world.

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“…CNT doped PEDOT showed an enhancement in electrical stability and conductivity compared to PEDOT, while neuron cellular activities were more or less the same [107] . PPy/graphene oxide (GO) composites demonstrated significantly lower impedance than Pt electrode and pure PPy when used as neural probes materials [108] .…”

Section: Bio-interface Of Carbon Nanotube and Graphene Based Materialmentioning

confidence: 94%

Bio‐Interface of Conducting Polymer‐Based Materials for Neuroregeneration

Weng

Diao

et al. 2015

Adv Materials Inter

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Nerve system diseases like Parkinson's disease, Huntington's disease, Alzheimer's disease, etc. seriously affect thousands of patients' lives every year, making them suffer from pains and inconvenience. Recently, biointerfaces between neural cells/tissues and polymer based biomaterials attracted worldwide attention due to the ability of polymer based biomaterials to serve as nerve conduits, drug carriers and neurites guidance platform in neuroregeneration. The role that bio-interface played and the way it interacted with neural tissues and cells have been thoroughly investigated by the researchers. In this paper we mainly focus on reviewing the bio-interface between nerve tissues/cells and advanced functional biocompatible polymers, such as conducting polymers and advanced carbon composite materials. These advanced polymers can provide combined interfacial stimulations including interfacial external neurotrophic factors (NTFs) delivery, electrical stimulation, surface guidance and molecules decoration to lesion cells and tissues to promote neuroregeneration in vitro and in vivo, and have contributed greatly to nerve diseases therapy. At the end of this review, the criteria of polymer based biomaterials utilized in neuroregeneration are summarized and the perspectives for future development of bio-interfaces are also discussed. Nerve system diseases like Parkinson's disease, Huntington's disease and Alzheimer's disease etc. seriously affect thousands of patients' lives every year, making the patients suffer from pains and inconvenience brought about by these diseases. Recently, bio-interface between neural cells/tissues and polymer based biomaterials attracted worldwide attention due to the ability of polymer based biomaterials to serve as nerve conduits, drug carrier and neurites guidance platform in neuroregeneration. The role that bio-interface played and the way it interacted with neural tissues and cells have been thoroughly investigated by the researchers.In this paper we mainly focus on reviewing bio-interface between nerve tissues/cells and advanced functional biocompatible polymers, such as conducting polymers and advanced carbon composites materials.. These advanced polymers can provide combined interfacial stimulations including interfacial NTFs delivery, electrical stimulation, surface guidance and molecules decoration to lesion cells and tissues to promote neuroregeneration in vitro and in vivo, and have contributed greatly to nerve diseases therapy. At the end of this review, the criteria of polymer based biomaterials utilized in neuroregeneration are summarized and the perspectives for future development of bio-interfaces are also discussed.

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Highly stable carbon nanotube doped poly(3,4-ethylenedioxythiophene) for chronic neural stimulation

Cited by 230 publications

References 52 publications

3D printing nano conductive multi-walled carbon nanotube scaffolds for nerve regeneration

3D printing nano conductive multi-walled carbon nanotube scaffolds for nerve regeneration

Progress in Research of Flexible MEMS Microelectrodes for Neural Interface

Bio‐Interface of Conducting Polymer‐Based Materials for Neuroregeneration

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