Highly sensitive voltammetric determination of kanamycin based on aptamer sensor for signal amplification

Song, Hai yan; Kang, Tian; Li, Na na; Lu, Li Ping; Cheng, Song

doi:10.1039/c6ay00152a

Cited by 34 publications

(7 citation statements)

References 26 publications

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“…Kanamycin is one the frequently used aminoglycoside antibiotics produced by Streptomyces kanamyceticus [63,64]. The increasing use of kanamycin is a threat to human health due to is ototoxicity, nephrotoxicity and neurotoxicity due to its residue in animal-derived products [65,66]. The European Commission has set the maximum residue limits (MRLs) or kanamycin in milk at 150 μg/kg [64,67,68].…”

Section: Antibiotics and Antibiotic Residuesmentioning

confidence: 99%

Application of Noble Metals in the Advances in Animal Disease Diagnostics

Tubalinal¹,

Lucero²,

Mangahas³

et al. 2022

Updates on Veterinary Anatomy and Physiology

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The advent of molecular biology and biotechnology has given ease and comfort for the screening and detection of different animal diseases caused by bacterial, viral, and fungal pathogens. Furthermore, detection of antibiotics and its residues has advanced in recent years. However, most of the process of animal disease diagnostics is still confined in the laboratory. The next step to conduct surveillance and prevent the spread of animal infectious diseases is to detect these diseases in the field. Through the discovery and continuous development in the field of nanobiotechnology, it was found that incorporation of noble metal nanoparticles to biotechnology tools such as the loop-mediated isothermal amplification (LAMP), lateral flow assays (LFAs) and dipsticks provided a promising start to conduct point-of-care diagnostics. Moreover, the modification and application of nanoparticle noble metals has increased the stability, effectiveness, sensitivity and overall efficacy of these diagnostic tools. Thus, recent advances in disease diagnostics used these noble metals such as gold, silver and platinum.

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Section: Antibiotics and Antibiotic Residuesmentioning

confidence: 99%

Application of Noble Metals in the Advances in Animal Disease Diagnostics

Tubalinal¹,

Lucero²,

Mangahas³

et al. 2022

Updates on Veterinary Anatomy and Physiology

View full text Add to dashboard Cite

show abstract

“…Sometimes, in order to obtain high specificity and improve the sensitivity of aptasensors, the biocatalytic properties of enzymes are used to detect and amplify the analysis of targets with their aptamers. For example, horseradish peroxidase (HRP) [ 108 ] or glucose oxidase (GlO) [ 113 ], conjugated with AuNP-cDNA, have been used as biocatalysts for signal amplification for the detection of kanamycin.…”

Section: Aptasensors For Different Antibiotic Classesmentioning

confidence: 99%

Aptamer-Based Biosensors for Antibiotic Detection: A Review

2018

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Antibiotic resistance and, accordingly, their pollution because of uncontrolled usage has emerged as a serious problem in recent years. Hence, there is an increased demand to develop robust, easy, and sensitive methods for rapid evaluation of antibiotics and their residues. Among different analytical methods, the aptamer-based biosensors (aptasensors) have attracted considerable attention because of good selectivity, specificity, and sensitivity. This review gives an overview about recently-developed aptasensors for antibiotic detection. The use of various aptamer assays to determine different groups of antibiotics, like β-lactams, aminoglycosides, anthracyclines, chloramphenicol, (fluoro)quinolones, lincosamide, tetracyclines, and sulfonamides are presented in this paper.

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“…Song et al . reported a new kanamycin aptamer as the sensor and HRP as a biocatalyst for signal amplification using a complementary DNA strand . Liu et al .…”

Section: Self‐assemblymentioning

confidence: 99%

The Supramolecular Self‐Assembly of Aminoglycoside Antibiotics and their Applications

et al. 2019

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Aminoglycosides, a class of antibiotics that includes gentamicin, kanamycin, neomycin, streptomycin, tobramycin and apramycin, are derived from various streptomyces species. Despite the significant increase in the antibacterial resistant pathogens, aminoglycosides remain an important class of antimicrobial drugs due to their unique chemical structure which offers a broad spectrum of activity. The modification of antibiotics and their subsequent use in supramolecular chemistry is rarely reported. Given the importance of aminoglycosides, here we give a brief overview on the modification of 4,5‐ and 4,6‐disubstituted deoxystreptamine classes of aminoglycosides through supramolecular chemistry and their potential for real world applications. We also make the case that the work in this area is gaining momentum, and there are significant opportunities to meet the challenges of modern antibiotics through the modification of aminoglycosides by harnessing the advantages of supramolecular chemistry.

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Highly sensitive voltammetric determination of kanamycin based on aptamer sensor for signal amplification

Abstract: In this paper, a novel aptamer sensor for kanamycin was prepared by using a complementary DNA (cDNA) strand of kanamycin aptamer as sensor and horseradish peroxidase (HRP) as a biocatalyst for signal amplification.

Cited by 34 publications

References 26 publications

Application of Noble Metals in the Advances in Animal Disease Diagnostics

Application of Noble Metals in the Advances in Animal Disease Diagnostics

Aptamer-Based Biosensors for Antibiotic Detection: A Review

The Supramolecular Self‐Assembly of Aminoglycoside Antibiotics and their Applications

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