Highly sensitive thermometer using a vacuum-packed Si resonator in a microfluidic chip for the thermal measurement of single cells

Inomata, Naoki; Toda, Masaya; Ono, Takahito

doi:10.1039/c6lc00949b

Cited by 41 publications

(50 citation statements)

References 37 publications

(68 reference statements)

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“…Conventional permanent magnets were used for levitation. The balance between the magnetic field from the magnets and the diamagnetism materials is shown in (1).…”

Section: Methodsmentioning

confidence: 99%

“…In microfabricated temperature detection sensors or systems, thermal insulation should be carefully considered because heat loss depends on the surface-volume ratio. As thermal insulation methods, a suspended membrane under sensors and vacuumsurrounded structure is effective, and some papers have employed these methods [1,2]; however, heat will flow as long as there are contacts of two materials, which makes it difficult to obtain the true values of heat amount.…”

Section: Introductionmentioning

confidence: 99%

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Diamagnetic Levitation Thermometer

Inomata

Ono

2020

IEEJ Transactions Elec Engng

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This paper reports a diamagnetic levitation thermometer using a pyrolytic graphite (PG). The levitation height of diamagnetic materials depends on the temperature. The system is composed of a PG disc, permanent magnet for driving, non‐contact laser displacement meter, and spot heater. We evaluated the height in air and vacuum changing the temperature of the PG disc, and the disc changes its height as to be −1.49 and 1.55 µm/°C in air and vacuum, respectively. Differential thermal analysis of polystyrene is demonstrated. The potential of the diamagnetic levitation as a new principle measuring temperature changes is indicated. © 2020 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.

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“…Conventional permanent magnets were used for levitation. The balance between the magnetic field from the magnets and the diamagnetism materials is shown in (1).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diamagnetic Levitation Thermometer

Inomata

Ono

2020

IEEJ Transactions Elec Engng

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“…We concluded that the developed device is very useful in observing the thermal phenomenon of biological cells . Experimentally, the heat loss of the sensor can be evaluated from temperature measurements when the sample stage is heated using a laser (Fig.…”

Section: Applications Of the Cantilever Beam Temperature Sensormentioning

confidence: 98%

Cantilever beam temperature sensors for biological applications

Toda

Inomata

Ono

et al. 2017

IEEJ Transactions Elec Engng

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This review presents two types of cantilever beams employed as highly sensitive temperature sensors. One type is fabricated from composite materials and is operated in the deflection mode. The second type, used as a temperature sensor and presented in this review, is a resonant cantilever beam. The materials used for the fabrication of the bimaterial cantilever beam are silicon or silicon nitride and thin metallic films such as gold or aluminum. When the temperature changes, the different coefficients of thermal expansion of the metal and silicon cause the sensor to deflect. Considering the models of temperature measurement for biological cells, the heat should be applied locally at the tip of the cantilever beam. Formulas for the calculation of the deflection as a function of incident power applied at the free end of the cantilever beam operated in a liquid are presented in this review. The natural convective heat transfer coefficient was estimated by using the mathematical model and experimental values. For biological applications, the cantilever beam temperature sensor was operated in a liquid, and the heat transfer coefficients were between 381 and 642 W/m 2 K when the temperature applied to the cantilever's free end varied from 28 to 71.8 • C. The resonant cantilever beam was also demonstrated as a sensitive temperature sensor for biological applications. As a thermogenic sample, brown fat cells (BFCs), which are related to metabolic heat production, are employed. The working principle of the resonator cantilever beam temperature sensor is based on the shift in resonant frequency in response to temperature changes. The resonant frequency and the temperature coefficient were 960 kHz and 22.0 ppm/K, respectively. The measurements were performed by stimulating the activity of BFCs by flowing a norepinephrine (NE) solution (1 μM).

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“…Considerable ongoing research has been devoted for the development of simple and cost-effective sensor systems for biological applications [1][2][3][4][5][6][7][8][9][10]. The detection of thermal activities of biological cells is of particular interest [11][12][13][14][15]. Measurement and temperature control of biological cells are considerable contributors to the development of new research methods in the study of genetics and the development of diseases, and they provide further insight into the behavior of cancerous tumors [16,17].…”

Section: Introductionmentioning

confidence: 99%

Modeling of an Optically Heated MEMS-Based Micromechanical Bimaterial Sensor for Heat Capacitance Measurements of Single Biological Cells

Alodhayb

2019

Sensors

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Detection of thermal activities of biological cells is important for biomedical and pharmaceutical applications because these activities are closely associated with the conformational change processes. Calorimetric measurements of biological systems using bimaterial microcantilevers (BMC) have increasingly been reported with the ultimate goal of developing highly sensitive and inexpensive techniques with real-time measurement capability techniques for the characterization of dynamic thermal properties of biological cells. BMCs have been established as highly sensitive calorimeters for the thermal analysis of cells and liquids. In this paper, we present a simulation model using COMSOL Multiphysics and a mathematical method to estimate the heat capacity of objects (treated here as a biological cell) placed on the surface of a microcantilever. By measuring the thermal time constant, which is obtained from the deflection curve of a BMC, the heat capacity of a sample can be evaluated. With this model, we can estimate the heat capacity of single biological cells using a BMC, which can potentially be used for the thermal characterization of different biological samples.

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Highly sensitive thermometer using a vacuum-packed Si resonator in a microfluidic chip for the thermal measurement of single cells

Cited by 41 publications

References 37 publications

Diamagnetic Levitation Thermometer

Diamagnetic Levitation Thermometer

Cantilever beam temperature sensors for biological applications

Modeling of an Optically Heated MEMS-Based Micromechanical Bimaterial Sensor for Heat Capacitance Measurements of Single Biological Cells

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