Highly sensitive SPR-based PCF bio sensor for plasma cell detection in human blood for the detection of early stage cancer

Rajeswari, D.; Revathi, A

doi:10.1016/j.ijleo.2022.168897

Cited by 30 publications

(13 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A comparison between the proposed V-shaped cancer detection sensor with the previously reported sensors in (Sani et al 2022), (Verma, Kumar and Jindal, 2022), (Chaudhary, Kumar and Kumar, 2022), (Rajeswari and Revathi 2022), (Yasli 2021), (Jabin et al 2019), (Ayyanar et al 2018), (Mollah et al 2020), (Ramanujam et al 2019), (Jindal et al 2016), (Abdelghaffar et al 2022) and (Ramanujam et al 2019), (Singh and Prajapati 2023), (Almawgani et al 2022), (Malek et al 2022), (Yasli 2022), (Nayak 2023) is depicted in Table 6. It is evident that the sensitivity of the proposed early cancer detection biosensor is greater than the introduced biosensors in (Jabin et al 2019), (Ayyanar et al 2018), (Ramanujam et al 2019), (Jindal et al 2016), (Sani et al 2022), (Almawgani et al 2022), (Malek et al 2022), (Yasli 2022) (Nayak 2023) (Abdelghaffar et al 2022)and (Ramanujam et al 2019).…”

Section: Fabrication Tolerance Studymentioning

confidence: 99%

“…Further, (Verma, Kumar and Jindal, 2022) and (Singh and Prajapati 2023) have used dual plasmonic materials with higher fabrication cost. In Addition, (Mollah et al 2020) and (Rajeswari and Revathi 2022) have used internal coating for the plasmonic material through the PCF which is a challenge for fabrication. Further, analyte infiltration will be difficult through the PCF air holes as reported in (Mollah et al 2020).…”

Section: Fabrication Tolerance Studymentioning

confidence: 99%

“…In addition, plasmonic PCF biosensor for cancer detection of a single living cell was developed with sensitivities of 7142.86 nm/ RIU and − 757 RIU −1 for MCF-7, and Hela cell, respectively (Yasli 2021). Plasmonic PCF breast cancer cells biosensor based on ITO coated layer was introduced with sensitivities of 6701.03 nm/RIU and 5154.63 nm/RIU for x-and y-polarization, respectively (Rajeswari and Revathi 2022). Additionally, bottom side polished PCF based biosensor for early cancer detection was presented with sensitivity of 22,857 nm/RIU for blood cancer, 20000 nm/ RIU for cervical cancer, 20714 nm/RI for adrenal gland cancer, 20000 nm/RIU for skin cancer, and 21,428, 25,000 nm/RIU for breast cancer (type-1and type-2)), respectively (Singh and Prajapati 2023).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Highly sensitive V-shaped SPR PCF biosensor for cancer detection

et al. 2023

View full text Add to dashboard Cite

In this paper, a novel design of photonic crystal fiber (PCF) biosensor based on surface plasmon resonance (SPR) is introduced and analyzed for cancer cell detection. The full vectorial finite element method (FVFEM) is used throughout the numerical analysis of the suggested biosensor. The reported PCF has a V-shaped surface that is coated with ZrN as a plasmonic material. A coupling occurs between the core guided mode and surface plasmon mode SPM which depends on the studied analyte. Such a coupling is improved by using the suggested V-shape geometry which increases the sensor sensitivity.The geometrical parameters are optimized to achieve high sensor sensitivity. The proposed biosensor has high optical sensitivity of 6214.28, 3800, and 5008.33 nm/RIU, for quasi-transverse magnetic (TM), and 6000 nm/RIU, 4400 nm/RIU, and 5333.3 nm/RIU, for quasi-transverse magnetic (TE), for breast, basal, and cervical cancer cells, respectively. The reported optical sensor can pave the way for efficient and simple technique for cancer detection with low cost and high sensitivity instead of surgical and chemical techniques.

show abstract

Section: Fabrication Tolerance Studymentioning

confidence: 99%

Section: Fabrication Tolerance Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Highly sensitive V-shaped SPR PCF biosensor for cancer detection

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Several ways have been reported to overcome this, using surface plasmon resonance (SPR) technology based on photonic crystal fiber (PCF) will be a good technique in detecting analyte samples [1], for various applications such as in the medical world [2], food safety [3], environment and biochemistry [4]. SPR sensors are widely used in glucose sensing [5], virus detection [6], gas sensing [7], blood type detection [8], environmental sensing [9], food quality measurement [10], telemedicine [11], sensing temperature [12]- [15] and antigen-antibody interactions and other biochemical applications [13].…”

Section: Introductionmentioning

confidence: 99%

Hexagonal two layers-photonics crystal fiber based on surface plasmon resonance with gold coating biosensor easy to fabricate

Azhar

Ramadhan

Saktioto

et al. 2022

IJEECS

View full text Add to dashboard Cite

<span>In this paper, we investigate a hexagonal two-layer photonic crystal fiber based on surface plasmon resonance (HT-PCF-SPR) which is easy to fabricate as a sensor for detecting the refractive index of analytes. After performing numerical simulations using COMSOL multiphysics based on the finite element method (FEM), it was found that the HT-PCF-SPR could detect the analyte's refractive index in the range 1.34-1.37 RIU and in the wavelength range from 730 nm to 810 nm. The plasmonic material used in the design is gold with a thickness of 40 nm which is located outside the layer and in two opposite air holes in the core. The HT-PCF-SPR design has good performance in detecting analytes, it is found that the sensitivity in detecting analytes is 2,000 nm/RIU, meaning that every 1 RIU shift of analyte shifts the wavelength by 2000 nm. Meanwhile, the sensor resolution obtained from the design is 6.67×10-5 RIU, and it is found that the larger the air hole, the greater the confinement loss value.</span>

show abstract

“…In the field of cancer detection, SPR sensors can be used to study the behavior of human cells, and also to analyze the change of the protein in the cell to determine if this cell is normal or cancerous (Bellassai et al 2019;Rajeswari and Revathi 2022). On the other hand, diabetes patients can beneficiate from SPR sensors, as these sensors can detect the glucose level but in a more convenient way with very high accuracy (Shen et al 2007).…”

Section: Introductionmentioning

confidence: 99%

ZnSe-based highly-sensitive SPR biosensor for detection of different cancer cells and urine glucose levels

et al. 2022

View full text Add to dashboard Cite

As detection of cancer and diabetes diseases has captured a great attention in the field of biosensing, many ways were introduced to detect these diseases with high accuracy. This paper presents a novel use of zinc selenide (ZnSe) semiconductor material to enhance the sensitivity of a conventional Ag-based surface plasmon resonance biosensor. The proposed sensor structure is simple (BK7 prism/Ag/ZnSe), cost-effective, and easy to design and fabricate. The sensor is tested in the detection of different cancerous cells in human blood, showing an excellent sensitivity of 359$$^\circ$$ ∘ /RIU. In addiion, it is tested to detect various glucose levels in human urine, and it provides a very high performance with a sensitivity of 366.6$$^\circ$$ ∘ /RIU, which is 70% better than that of a similar reported work. Thus, the proposed biosensor is capable efficiently to detect various kinds of cancer cells and different glucose concentrations in urine.

show abstract

Highly sensitive SPR-based PCF bio sensor for plasma cell detection in human blood for the detection of early stage cancer

Cited by 30 publications

References 36 publications

Highly sensitive V-shaped SPR PCF biosensor for cancer detection

Highly sensitive V-shaped SPR PCF biosensor for cancer detection

Hexagonal two layers-photonics crystal fiber based on surface plasmon resonance with gold coating biosensor easy to fabricate

ZnSe-based highly-sensitive SPR biosensor for detection of different cancer cells and urine glucose levels

Contact Info

Product

Resources

About