ZnSe-based highly-sensitive SPR biosensor for detection of different cancer cells and urine glucose levels

Abstract

As detection of cancer and diabetes diseases has captured a great attention in the field of biosensing, many ways were introduced to detect these diseases with high accuracy. This paper presents a novel use of zinc selenide (ZnSe) semiconductor material to enhance the sensitivity of a conventional Ag-based surface plasmon resonance biosensor. The proposed sensor structure is simple (BK7 prism/Ag/ZnSe), cost-effective, and easy to design and fabricate. The sensor is tested in the detection of different cancerous cells in human blood, showing an excellent sensitivity of 359$$^\circ$$ ∘ /RIU. In addiion, it is tested to detect various glucose levels in human urine, and it provides a very high performance with a sensitivity of 366.6$$^\circ$$ ∘ /RIU, which is 70% better than that of a similar reported work. Thus, the proposed biosensor is capable efficiently to detect various kinds of cancer cells and different glucose concentrations in urine.

A Concise Review of the Progress in Photonic Sensing Devices

“…The detection of cancer and diabetes diseases is a crucial area of research in biosensing. To improve the accuracy of detection, researchers have introduced various methods, including the application of zinc selenide (ZnSe) semiconductor material to improve the sensitivity of a standard Ag-based SPR biosensor [64]. The suggested sensing device structure, as shown in Figure 3a is simple, economical, and simple to fabricate.…”

Surface Plasmon Resonance Biosensor with High Sensitivity for Detecting SARS-CoV-2

“…Attaining highest performance in an SPR biosensor requires maximizing sensitivity. Surface Plasmon Resonance (SPR)-based biosensors are utilized across various domains, encompassing different applications like gas sensing, food safety, enzyme detection, chemical and biochemical sensing, SARS-CoV-2 detection, tuberculosis, DNA-DNA hybridization, protein-protein interactions, protein-DNA interactions, enzyme-substrate studies [16][17][18][19][20][21][22][23].…”

The Effect of Graphene Oxide on Optical, Ferroelectric, and Catalytic Properties of Protein-Encapsulated ZnSe Nanocomposite

“…[10][11][12] For instance, Moustafa et al have introduced a highly sensitive biosensor based on ZnSe, capable of detecting various cancer cells and measuring glucose levels in urine. 13 Additionally, Deb et al showcased the luminescent properties of ZnSe(S) alloyed quantum dots, highlighting the potential of ZnSe based quantum dots to develop new molecular probes for biomedical imaging. 14 The utilization of ZnSe quantum dots in biomedical applications faces significant constraints, such as aqueous dispersibility and biocompatibility.…”