Highly sensitive non-enzymatic glucose sensor based on carbon nanotube microelectrode set

Gupta, Pankaj; Gupta, Vandna K.; Huseinov, Artur; Rahm, Connor E.; Gazica, Kiera; Alvarez, Noe T.

doi:10.1016/j.snb.2021.130688

Cited by 30 publications

(11 citation statements)

References 86 publications

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“…It is evident from the results that the fabricated device can be used as a portable CGM device in the near future for diabetic applications. The sensitivity recorded in the current study using the wireless device (Au/Pt-black/Nf MNEA) is greater than the several non-enzymatic glucose sensors reported earlier [ 29 , 30 , 32 , 33 , 34 , 35 ]. The linear range reported in the present study is greater than many of the enzyme-free glucose sensors reported in the past decade [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ].…”

Section: Resultscontrasting

confidence: 70%

Sensitive Electrochemical Non-Enzymatic Detection of Glucose Based on Wireless Data Transmission

Kim

Chinnadayyala

et al. 2022

Sensors

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Miniaturization and wireless continuous glucose monitoring are key factors for the successful management of diabetes. Electrochemical sensors are very versatile and can be easily miniaturized for wireless glucose monitoring. The authors report a microneedle-based enzyme-free electrochemical wireless sensor for painless and continuous glucose monitoring. The microneedles (MNs) fabricated consist of a 3 × 5 sharp and stainless-steel electrode array configuration. Each MN in the 3 × 5 array has 575 µm × 150 µm in height and width, respectively. A glucose-catalyzing layer, porous platinum black, was electrochemically deposited on the tips of the MNs by applying a fixed cathodic current of 2.5 mA cm−2 for a period of 200 s. For the non-interference glucose sensing, the platinum (Pt)-black-coated MN was carefully packaged into a biocompatible ionomer, nafion. The surface morphologies of the bare and modified MNs were studied using field-emission scanning electron microscopy (FESEM) and energy-dispersive X-ray analysis (EDX). The wireless glucose sensor displayed a broad linear range of glucose (1→30 mM), a good sensitivity and higher detection limit of 145.33 μA mM−1 cm−2 and 480 μM, respectively, with bare AuMN as a counter electrode. However, the wireless device showed an improved sensitivity and enhanced detection limit of 445.75, 165.83 μA mM−1 cm−2 and 268 μM, respectively, with the Pt-black-modified MN as a counter electrode. The sensor also exhibited a very good response time (2 s) and a limited interference effect on the detection of glucose in the presence of other electroactive oxidizing species, indicating a very fast and interference-free chronoamperometric response.

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Section: Resultscontrasting

confidence: 70%

Sensitive Electrochemical Non-Enzymatic Detection of Glucose Based on Wireless Data Transmission

Kim

Chinnadayyala

et al. 2022

Sensors

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“…Carbon nanotubes (CNTs) are structurally featured with a hollow tubular nanostructure, large aspect ratio, significant electrical and mechanical properties, excellent stability, and good application prospects in glucose detection. , However, pristine CNTs usually exhibit inferior performance in terms of glucose oxidation, as these in situ-formed metal nanoparticles (NPs) are fully protected inside the multilayer graphitic carbons . From the point of view of growth mechanism, multifunctional CNTs are catalyzed by metals, which usually show a stable structure of carbon-coated metals that need to be activated before use for efficient glucose sensing. , Furthermore, multiwalled CNTs are usually hydrophobic carbons, while glucose is hydrophilic, making CNTs poorly selective for the adsorption of glucose molecules. , Under these circumstances, it remains a huge challenge to resolve the glucose affinity as well as the adequate exposure of active metal species inside CNTs as nonenzymatic sensor materials to show a high activity, selectivity, as well as stability.…”

Section: Introductionmentioning

confidence: 99%

“…23 From the point of view of growth mechanism, multifunctional CNTs are catalyzed by metals, which usually show a stable structure of carbon-coated metals that need to be activated before use for efficient glucose sensing. 24,25 Furthermore, multiwalled CNTs are usually hydrophobic carbons, while glucose is hydrophilic, making CNTs poorly selective for the adsorption of glucose molecules. 26,27 Under these circumstances, it remains a huge challenge to resolve the glucose affinity as well as the adequate exposure of active metal species inside CNTs as nonenzymatic sensor materials to show a high activity, selectivity, as well as stability.…”

Section: ■ Introductionmentioning

confidence: 99%

Partially Oxidized Carbon Nanomaterials with Ni/NiO Heterostructures as Durable Glucose Sensors

et al. 2023

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Conventional enzyme-based glucose biosensors have limited extensive applications in daily life because glucose oxidase is easily inactivated and is expensive. In this paper, we propose a strategy to prepare a new type of cost-effective, efficient, and robust nonenzymatic Ni-CNT-O for electrochemical glucose sensing. It is first followed by the pyrolysis of Ni-ABDC nanostrips using melamine to grow carbon nanotubes (CNTs) to give an intermediate product of Ni-CNT, which is further accompanied by partial oxidation to enable the facile formation of hierarchical carbon nanomaterials with improved hydrophilicity. A series of physicochemical characterizations have fully proved that Ni-CNT-O is a carbon-coated heterostructure of Ni and NiO nanoparticles embedded into coordination polymer-derived porous carbons. The obtained Ni-CNT-O exhibits a better electrocatalytic activity for glucose oxidation stemming from the synergistic effect of a metal element and a metal oxide than unoxidized Ni-CNT, which also shows high performance with a wide linear range from 1 to 3000 μM. It also offers a high sensitivity of 79.4 μA mM −1 cm −2 , a low detection limit of 500 nM (S/N = 3), and a satisfactory long-term durability. Finally, this glucose sensor exhibits good reproducibility, high selectivity, as well as satisfactory results by comparing the current response of simulated serum within egg albumen.

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“…While the high electrical conductivity of earth-abundant copper is utilized for catalytic oxidation of glucose, its limited working range and poor stability in neutral environment should be addressed. [20][21][22] CoFe Prussian blue analogues (PBAs), a well-known family of non-oxide coordination compounds, have also recently been found to be active towards glucose oxidation. [23][24][25][26] We recently showed that coordinatively unsaturated cobalt ions in Prussian blue (PB) structure could transform glucose to gluconolactone molecule once cobalt ions are oxidized to their 3 + oxidation states.…”

Section: Introductionmentioning

confidence: 99%

Selective Glucose Sensing under Physiological pH with Flexible and Binder‐Free Prussian Blue Coated Carbon Cloth Electrodes

2022

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The frequent detection of physiological glucose levels from human blood or sweat requires the development of low-cost electrodes with high sensitivity and selectivity. In this work, we prepared a series of Prussian blue (PB) modified carbon cloth (CC) electrodes with different cyanoferrate groups. We achieved a sensitivity as high as 145.43 μA mm À 1 cm À 2 in a 0.1-6.5 mm concentration range with a response time below 2 s under physiological pH. The electrodes exhibited a superior selectivity of glucose in the presence of interfering agents, including sucrose, lactose, NaCl, ascorbic acid, and uric acid. The electrodes also showed outstanding long-term stability over 15 days. Furthermore, we performed comprehensive electrochemical and characterization studies to elucidate the role of the cyanoferrate group on the morphologic and electronic properties of non-enzymatic glucose sensors.

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Highly sensitive non-enzymatic glucose sensor based on carbon nanotube microelectrode set

Cited by 30 publications

References 86 publications

Sensitive Electrochemical Non-Enzymatic Detection of Glucose Based on Wireless Data Transmission

Sensitive Electrochemical Non-Enzymatic Detection of Glucose Based on Wireless Data Transmission

Partially Oxidized Carbon Nanomaterials with Ni/NiO Heterostructures as Durable Glucose Sensors

Selective Glucose Sensing under Physiological pH with Flexible and Binder‐Free Prussian Blue Coated Carbon Cloth Electrodes

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