Highly Sensitive Metamaterial Biosensor for Cancer Early Detection

Azab, Mohammad Y.; Hameed, Mohamed Farhat O.; Nasr, Abed M.; Obayya, S. S. A.

doi:10.1109/jsen.2021.3051075

Cited by 69 publications

(29 citation statements)

References 28 publications

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“…Table 3 cells in the second configuration of the biosensor when the graphene is in the core-cladding boundary of metal-dielectric waveguides. The simulation results show a high value of S for basal cancer compared to the previous research [40] that verifies our biosensor structure is more sensitive and specific for basal cancer.…”

Section: Cancer Samples In the Second Configurationsupporting

confidence: 72%

All-Optical Tunable Plasmonic Biosensor Made of Graphene and Metamaterial

2022

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Section: Cancer Samples In the Second Configurationsupporting

confidence: 72%

All-Optical Tunable Plasmonic Biosensor Made of Graphene and Metamaterial

2022

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“…Depending on the variation of biological samples, the analyte optical (the refractive index properties) of the sensing medium were varied according to the skin (Basal), cervical (HeLa), adrenal gland (PC12), blood (Jurkat), and breast (MCF-7 and MDA-MB-231) healthy and cancer cells’ refractive index variations. The data of the analyte’s refractive index in Table 2 was obtained from a recently reported work [ 31 , 57 , 58 ]. The normal cancer cell size varies depending on the type of cancer cell.…”

Section: Design Methodologymentioning

confidence: 99%

Highly Sensitive TiO2/Au/Graphene Layer-Based Surface Plasmon Resonance Biosensor for Cancer Detection

et al. 2022

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In this article, a hybrid TiO2/Au/graphene layer-based surface plasmon resonance (SPR) sensor with improved sensitivity and capability for cancer detection is presented. The finite element method (FEM) was used for numerical analysis. The proposed SPR biosensor was structured based on the angular analysis of the attenuated total reflection (ATR) method for the detection of various types of cancer using the refractive index component. The resonance angle shifted owing to the increment of normal and cancerous cells’ refractive index, which varied between 1.36 and 1.401 for six different types of normal and cancerous cells. According to numerical results, the obtained sensitivities for skin (basal), cervical (HeLa), adrenal gland (PC12), blood (Jurkat), and breast (MCF-7 and MDA-MB-231) cancer cells were 210 deg/RIU, 245.83 deg/RIU, 264.285 deg/RIU, 285.71 deg/RIU, 292.86 deg/RIU, and 278.57 deg/RIU, respectively. Furthermore, the detection accuracy (DA), figure of merits (FOM), and signal-to-noise ratio (SNR) were also obtained, with values of 0.263 deg−1, 48.02 RIU−1, and 3.84, respectively. Additionally, the distribution of the electric field and the propagation of the magnetic field for resonant and non-resonant conditions of the proposed structure were illustrated. It was found that an enhanced field was exhibited on the surface of the plasmonic material for resonant conditions. We also measured the penetration depth of 180 nm using decayed electric field intensity. Furthermore, the impact of using a TiO2/Au/graphene layer was demonstrated. We further conducted analyses of the effects of the thickness of the gold layer and the effects of additional graphene layers on overall sensitivities for six different types of cancer. The proposed TiO2/Au/graphene layered structure exhibited the highest overall sensitivity in terms of detecting cancerous cells from healthy cells. Moreover, the proposed sensor was numerically analyzed for a wide range of biological solutions (refractive index 1.33 –1.41), and the sensor linearity was calculated with a linear regression coefficient (R2) of 0.9858. Finally, numerical results obtained in this manuscript exhibited high sensitivity in comparison with previously reported studies.

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“…Photonic crystal fibers (PCF) also have been used to monitor cancerous cells, whilst the maximum values of sensing parameters were achieved for recognition of breast cancer (MCF-7) [ 112 ]. A polyamide substrate was also employed for immobilization of hexagonal gold layers, whilst an elevated yield confinement ensured a high sensitivity for monitoring basal, breast, cervical, and adrenal cancerous cells, the analysis being carried out using the full vectoral finite element methodology [ 113 ].…”

Section: Cellular Eventsmentioning

confidence: 99%

PC-12 Cell Line as a Neuronal Cell Model for Biosensing Applications

et al. 2022

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PC-12 cells have been widely used as a neuronal line study model in many biosensing devices, mainly due to the neurogenic characteristics acquired after differentiation, such as high level of secreted neurotransmitter, neuron morphology characterized by neurite outgrowth, and expression of ion and neurotransmitter receptors. For understanding the pathophysiology processes involved in brain disorders, PC-12 cell line is extensively assessed in neuroscience research, including studies on neurotoxicity, neuroprotection, or neurosecretion. Various analytical technologies have been developed to investigate physicochemical processes and the biosensors based on optical and electrochemical techniques, among others, have been at the forefront of this development. This article summarizes the application of different biosensors in PC-12 cell cultures and presents the modern approaches employed in neuronal networks biosensing.

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Highly Sensitive Metamaterial Biosensor for Cancer Early Detection

Cited by 69 publications

References 28 publications

All-Optical Tunable Plasmonic Biosensor Made of Graphene and Metamaterial

All-Optical Tunable Plasmonic Biosensor Made of Graphene and Metamaterial

Highly Sensitive TiO2/Au/Graphene Layer-Based Surface Plasmon Resonance Biosensor for Cancer Detection

PC-12 Cell Line as a Neuronal Cell Model for Biosensing Applications

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