Highly Sensitive Detection of Influenza A (H1N1) Virus With Silicon Nanonet BioFETs

Park, Chanoh; Choi, Wonyoung; Kim, Donghoon; Jin, Bo; Lee, Jeong-Soo

doi:10.1109/jsen.2019.2936216

Cited by 14 publications

(12 citation statements)

References 24 publications

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“…In addition, POCT was provided with smartphone to provide user interface for sharing sensing data in order to discover pandemic influenza infection at the early stages of an outbreak. Another ion sensitive FET based biosensor for the detection of H1N1 was fabricated using microfabrication technique by Lee & group ( Park et al, 2019 ). Highly sensitive silicon nanonet FET device was modified with biological receptor molecule (monoclonal antibody) for the quantification of H1N1 virus.…”

Section: Iomt-assisted Poc Biosensing For Infectious Diseasesmentioning

confidence: 99%

Internet of medical things (IoMT)-integrated biosensors for point-of-care testing of infectious diseases

Jain

Nehra

Kumar

et al. 2021

Biosensors and Bioelectronics

242

155

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On global scale, the current situation of pandemic is symptomatic of increased incidences of contagious diseases caused by pathogens. The faster spread of these diseases, in a moderately short timeframe, is threatening the overall population wellbeing and conceivably the economy. The inadequacy of conventional diagnostic tools in terms of time consuming and complex laboratory-based diagnosis process is a major challenge to medical care. In present era, the development of point-of-care testing (POCT) is in demand for fast detection of infectious diseases along with “on-site” results that are helpful in timely and early action for better treatment. In addition, POCT devices also play a crucial role in preventing the transmission of infectious diseases by offering real-time testing and lab quality microbial diagnosis within minutes. Timely diagnosis and further treatment optimization facilitate the containment of outbreaks of infectious diseases. Presently, efforts are being made to support such POCT by the technological development in the field of internet of medical things (IoMT). The IoMT offers wireless-based operation and connectivity of POCT devices with health expert and medical centre. In this review, the recently developed POC diagnostics integrated or future possibilities of integration with IoMT are discussed with focus on emerging and re-emerging infectious diseases like malaria, dengue fever, influenza A (H1N1), human papilloma virus (HPV), Ebola virus disease (EVD), Zika virus (ZIKV), and coronavirus (COVID-19). The IoMT-assisted POCT systems are capable enough to fill the gap between bioinformatics generation, big rapid analytics, and clinical validation. An optimized IoMT-assisted POCT will be useful in understanding the diseases progression, treatment decision, and evaluation of efficacy of prescribed therapy.

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Section: Iomt-assisted Poc Biosensing For Infectious Diseasesmentioning

confidence: 99%

Internet of medical things (IoMT)-integrated biosensors for point-of-care testing of infectious diseases

Jain

Nehra

Kumar

et al. 2021

Biosensors and Bioelectronics

242

155

View full text Add to dashboard Cite

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“…The fabrication processes of BioFETs can allow cost-effective and customized sensor platform for biomedical applications. For example, silicon deposition using e-beam lithography and chemical vapor deposition can build H1N1 virus and uranyl FET sensors, respectively [23,24]. The study of fabrication of silicon nanowire (SiNW) as transducing nanomaterial that enables label free, ultrasensitive, real-time detection is also actively underway.…”

Section: Biofet Using Other Materials: Silicon Inorganic Compounds mentioning

confidence: 99%

A review of BioFET’s basic principles and materials for biomedical applications

Sung

Koo

2021

Biomed. Eng. Lett.

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Interest in biomolecular sensors for diagnosis of early diseases and prognosis of the diseases is increasing day by day. Among them, FET-based sensors are very useful in that of their versatile operating characteristics using various materials. Herein, after addressing the basic principles of BioFET, we conduct an overall review of BioFET on two of the main structural elements: transducing materials and probes. Transducing materials were classified into graphene, carbon nanotube, silicon, MOF, etc., and probes were classified into antibodies, enzymes, aptamers, etc.. The important elements in designing BioFETs, such as electrical properties of each material, Debye length, and fabrication process are introduced along with their respective structures and materials. After the review of each of these structures and characteristics, examples are discussed along with sensitivity, selectivity, and limit of detection. In addition to the operating aspects of the senser, novel processes, treatments, and materials that can be considered for various purposes are also introduced. Based on the understanding, an overview of diverse examples is given by dividing the applications of BioFET into three main types: antigen sensing, biomarker sensing, and drug effect monitoring. Focusing on these general reviews, we conclude how the future direction of development will move forward and what the main challenge is.

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“…To selectively recognize target biomolecules or bioparticles, the gate insulator surface is functionalized with respective receptors (e.g., antibodies, antigens or ssDNA). the electrostatic detection of various intact virus particles, including several subtypes of influenza A [H1N1 (Hideshima et al, 2019;Park et al, 2019), H3N2 (Shen et al, 2012), H5N1 (Hideshima et al, 2019), H5N2 (Chiang et al, 2012)], human immunodeficiency virus (HIV) (Kim et al, 2019), rotavirus (Liu et al, 2013), Ebola (Jin et al, 2019), and SARS-CoV-2 (Seo et al, 2020). For instance, a SiNW biosensor for the rapid (within minutes) and low-cost diagnosis of seasonal flu that could detect H3N2 viruses in clinical, exhaled breath condensate samples down to ∼3 × 10 4 particles/mL, was developed by Shen et al (2012).…”

Section: Intact Virus Particle Detectionmentioning

confidence: 99%

“…16 aM) has been demonstrated by a reusable SiNW-FET with reversible surface functionalization strategy (Chiang et al, 2012). More recently, a highly sensitive silicon-nanonet FET for the detection of H1N1 influenza A, which is one of the most virulent human pathogens among various types of influenza, was realized (Park et al, 2019).…”

Section: Intact Virus Particle Detectionmentioning

confidence: 99%

“…The biosensor was applied in fecal samples spiked with different concentrations (10-10 4 pfu/mL) of rotavirus solution. Influenza A, H1N1 Virus particle Dual-channel FET 10 0.5 -10 8.5 TCID 50 /mL 10 0.5 TCID 50 /mL Hideshima et al, Nanonet FET 0.01-100 ng/mL 10 pg/mL Park et al, 2019 SiNW-FET n.s. ∼3 × 10 4 particles/mL Shen et al,…”

Section: Intact Virus Particle Detectionmentioning

confidence: 99%

See 1 more Smart Citation

Field-Effect Sensors for Virus Detection: From Ebola to SARS-CoV-2 and Plant Viral Enhancers

Poghossian¹,

Jablonski

Molinnus

et al. 2020

Front. Plant Sci.

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Coronavirus disease 2019 (COVID-19) is a novel human infectious disease provoked by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, no specific vaccines or drugs against COVID-19 are available. Therefore, early diagnosis and treatment are essential in order to slow the virus spread and to contain the disease outbreak. Hence, new diagnostic tests and devices for virus detection in clinical samples that are faster, more accurate and reliable, easier and cost-efficient than existing ones are needed. Due to the small sizes, fast response time, label-free operation without the need for expensive and time-consuming labeling steps, the possibility of real-time and multiplexed measurements, robustness and portability (point-of-care and on-site testing), biosensors based on semiconductor field-effect devices (FEDs) are one of the most attractive platforms for an electrical detection of charged biomolecules and bioparticles by their intrinsic charge. In this review, recent advances and key developments in the field of label-free detection of viruses (including plant viruses) with various types of FEDs are presented. In recent years, however, certain plant viruses have also attracted additional interest for biosensor layouts: Their repetitive protein subunits arranged at nanometric spacing can be employed for coupling functional molecules. If used as adapters on sensor chip surfaces, they allow an efficient immobilization of analyte-specific recognition and detector elements such as antibodies and enzymes at highest surface densities. The display on plant viral bionanoparticles may also lead to long-time stabilization of sensor molecules upon repeated uses and has the potential to increase sensor performance substantially, compared to conventional layouts. This has been demonstrated in different proof-of-concept biosensor devices. Therefore, richly available plant viral particles, non-pathogenic for animals or humans, might gain novel importance if applied in receptor layers of FEDs. These perspectives are explained and discussed with regard to future detection strategies for COVID-19 and related viral diseases.

show abstract

Highly Sensitive Detection of Influenza A (H1N1) Virus With Silicon Nanonet BioFETs

Cited by 14 publications

References 24 publications

Internet of medical things (IoMT)-integrated biosensors for point-of-care testing of infectious diseases

Internet of medical things (IoMT)-integrated biosensors for point-of-care testing of infectious diseases

A review of BioFET’s basic principles and materials for biomedical applications

Field-Effect Sensors for Virus Detection: From Ebola to SARS-CoV-2 and Plant Viral Enhancers

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