Highly sensitive contactless conductivity microchips based on concentric electrodes for flow analysis

Lima, Renato S.; Piazzetta, Maria H. O.; Gobbi, Ângelo L.; Segato, Thiago Pinotti; Cabral, Murilo F.; Machado, Sérgio Antônio Spínola; Carrilho, Emanuel

doi:10.1039/c3cc45797d

Cited by 17 publications

(16 citation statements)

References 41 publications

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“…Conversely, our platform has some disadvantages such as low analytical frequency and generation of high waste content. A perspective to overcome such downsides concerns the coupling of the platform in microfluidic devices [55]. Herein, one alternative is the integration of the hydrophobic membrane in a microchip by mechanically engraving different layers of thermoplastic polymers containing microchannels and reservoirs [56].…”

Section: Discussionmentioning

confidence: 99%

An integrated platform for gas-diffusion separation and electrochemical determination of ethanol on fermentation broths

Giordano

Vieira

Gobbi

et al. 2015

Analytica Chimica Acta

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Section: Discussionmentioning

confidence: 99%

An integrated platform for gas-diffusion separation and electrochemical determination of ethanol on fermentation broths

Giordano

Vieira

Gobbi

et al. 2015

Analytica Chimica Acta

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“…Lima et al. have thus also implemented concentric electrodes in a microfluidic flow‐through device, which encompass the whole channel and have demonstrated a strong improvement in sensitivity compared to conventional planar electrodes . An LOD of 344 pM was reported for flowing stream of LiClO 4 using the concentric electrodes, which was almost four orders of magnitude lower compared to planar electrodes.…”

Section: Instrumentationmentioning

confidence: 99%

Contactless conductivity detection for analytical techniques—Developments from 2012 to 2014

Kubáň

Hauser

2014

Electrophoresis

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The review covers the progress of capacitively coupled contactless conductivity detection over the 2 years leading up to mid-2014. During this period many new applications for conventional CE as well as for microchip separation devices have been reported; prominent areas have been clinical, pharmaceutical, forensic, and food analyses. Further progress has been made in the development of field portable instrumentation based on CE with contactless conductivity detection. Several reports concern the combination with sample pretreatment techniques, in particular electrodriven extractions. Accounts of arrays of contactless conductivity detectors have appeared, which have been created for quite different tasks requiring spatially resolved information. The trend of the use of contactless conductivity measurements for applications other than CE has continued.

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“…130 μm. The decrease in this thickness would lead to improvements in the detectability levels by promoting a more effective capacitive coupling using the current electronics . Once the focus of this study was dedicated to the development of high‐relief masters in an alternative material, the detection conditions were not optimized.…”

Section: Resultsmentioning

confidence: 99%

Simple, rapid and, cost‐effective fabrication of PDMS electrophoresis microchips using poly(vinyl acetate) as photoresist master

et al. 2016

Self Cite

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This study describes a simple, rapid, and cost-effective fabrication of PDMS electrophoresis microchips using poly(vinyl acetate) (PVAc) emulsion as photoresist master. High-relief microfluidic structures were defined on poly(vinyl acetate) previously deposited on printed circuit boards surfaces without cleanroom facilities and sophisticated instrumentation. After a UV exposure, channels with heights ranging from 30 to 140 μm were obtained by controlling the emulsion mass deposited on the master surface. The developing stage was performed using water rather than the organic solvents that are applied for conventional masks. The surface morphology was characterized by optical imaging, profilometry, and SEM. Based on the achieved results, the proposed method offers suitable reproducibility for the prototyping of electrophoresis microchips in PDMS. The feasibility of the resulting PDMS electrophoresis chips was successfully demonstrated with the separation of major inorganic cations within 100 s using a contactless conductivity detection system. The separation efficiencies ranged from ca. 67 900 to 125 600 plates/m. Due to the satisfactory performance and simplified instrumentation, we believe this fabrication protocol presents potential to be implemented in any chemical, biochemical, or biological laboratory.

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Highly sensitive contactless conductivity microchips based on concentric electrodes for flow analysis

Cited by 17 publications

References 41 publications

An integrated platform for gas-diffusion separation and electrochemical determination of ethanol on fermentation broths

An integrated platform for gas-diffusion separation and electrochemical determination of ethanol on fermentation broths

Contactless conductivity detection for analytical techniques—Developments from 2012 to 2014

Simple, rapid and, cost‐effective fabrication of PDMS electrophoresis microchips using poly(vinyl acetate) as photoresist master

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