Highly Sensitive Cell Concentration Detection by Resonant Optical Tunneling Effect

Jian, Aoqun; Zou, Lu; Bai, Gang; Duan, Qianqian; Zhang, Yixia; Zhang, Qianwu; Sang, Shengbo; Zhang, Xuming

doi:10.1109/jlt.2019.2907786

Cited by 13 publications

(8 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This value is ≈39 times greater than that of cell concentration detection by the reflectance measurement of ROTE structure. [38] Moreover, Table 2 compares our photonic SHE sensor with some other classical glucose sensors, such as SPR, [28,29] resonance cavities, [39] U-shape fiber [40], and multimode interference. [41] From Table II, the proposed photonic SHE sensor is extremely superior in sensitivity, which demonstrates the excellent perfor-mance of our glucose concentration sensor based on photonic SHE.…”

Section: Resultsmentioning

confidence: 99%

Photonic Spin Hall Effect as a Highly Sensitive Refractive Index Sensing Platform for Glucose

Dong,

Xiang,

Cheng

2023

Annalen der Physik

View full text Add to dashboard Cite

This study presents an innovative refractive index (RI) sensor that measures glucose concentration by utilizing the photonic spin Hall effect (SHE) in a resonant optical tunneling effect (ROTE) structure. The ROTE structure consists of three InP layers with the high RI and two analyte layers (with a high‐low‐high‐low‐high RI distribution), in which glucose solution samples with the low RI are injected. By subjecting the InP layers to external bias‐assisted light, the photonic SHE can be flexibly manipulated, enabling the modulation of the sensing performance accordingly. It is found that the transverse shift of photonic SHE presents a large variation in response to the tiny change in glucose concentrations. By optimizing the parameters (i.e., intensity or wavelength) of bias light, the sensitivity of this sensor can reach as high as 735.7 µm RIU−1. Compared to traditional glucose sensors, this original work implements the novel photonic SHE with the superior sensing performance. Therefore, the proposed design shows promising potential for biomedical applications, such as medical diagnoses and drug discovery.

show abstract

Section: Resultsmentioning

confidence: 99%

Photonic Spin Hall Effect as a Highly Sensitive Refractive Index Sensing Platform for Glucose

Dong,

Xiang,

Cheng

2023

Annalen der Physik

View full text Add to dashboard Cite

show abstract

“…Additionally, the cell culture, on the basis of microfluidic technology combined with other technologies, can be used to meet some special needs. For example, the platform based on the amalgamation of microfluidics and micro-optical components is of great importance for optical sensing, fluorescence analysis, and cell detection [ 104 , 105 , 106 ]. The microfluidic device integrated with acoustics could achieve non-contact, non-invasive, adjustable, and precise cell manipulation.…”

Section: Manufacture Methodologiesmentioning

confidence: 99%

Recent Advances of Organ-on-a-Chip in Cancer Modeling Research

Liu

Zhang

et al. 2022

Biosensors

View full text Add to dashboard Cite

Although many studies have focused on oncology and therapeutics in cancer, cancer remains one of the leading causes of death worldwide. Due to the unclear molecular mechanism and complex in vivo microenvironment of tumors, it is challenging to reveal the nature of cancer and develop effective therapeutics. Therefore, the development of new methods to explore the role of heterogeneous TME in individual patients’ cancer drug response is urgently needed and critical for the effective therapeutic management of cancer. The organ-on-chip (OoC) platform, which integrates the technology of 3D cell culture, tissue engineering, and microfluidics, is emerging as a new method to simulate the critical structures of the in vivo tumor microenvironment and functional characteristics. It overcomes the failure of traditional 2D/3D cell culture models and preclinical animal models to completely replicate the complex TME of human tumors. As a brand-new technology, OoC is of great significance for the realization of personalized treatment and the development of new drugs. This review discusses the recent advances of OoC in cancer biology studies. It focuses on the design principles of OoC devices and associated applications in cancer modeling. The challenges for the future development of this field are also summarized in this review. This review displays the broad applications of OoC technique and has reference value for oncology development.

show abstract

“…The typical ROTE structure consists of five layers (input layer, first tunneling gap, central slab, second tunneling gap, and output layer) with an alternative RI distribution of high and low. When the incident angle is greater than the total reflection angle and the tunneling gap is thin enough, the incident light can pass through the tunneling gap and resonate in the central slab [ 21 ]. To analyze the manner of the EP, the coupled ROTE resonators model is designed as shown in Figure 2 c. The coupling strength between the directly coupled resonators can be tuned by adjusting the width of the coupling layer.…”

Section: Theoretical Analysis and Simulationmentioning

confidence: 99%

“…The ROTE resonators provide the benefits of low cost, effortless equipping, easy fabrication and integration. Several ROTE-based sensors, such as acceleration sensors [ 20 ] and refractive index (RI) sensors [ 21 , 22 ], have been theoretically or experimentally demonstrated. An EP biosensor was proposed and designed by a parity-time (PT) coupled symmetric ROTE resonator [ 23 ] for low-concentration carcinoembryonic antigen (CEA) detection.…”

Section: Introductionmentioning

confidence: 99%

Biosensing Near the Exceptional Point Based on Resonant Optical Tunneling Effect

et al. 2021

Self Cite

View full text Add to dashboard Cite

Inspired by exceptional point (EP) sensing in non-Hermitian systems, in this work, a label-free biosensor for detecting low-concentration analytes is proposed, via a special multilayer structure: a resonant optical tunneling resonator. Due to the square root topology near the exceptional point, a recognized target analyte perturbs the system deviated from the exceptional point, leading to resolvable modes splitting in the transmission spectrum. The performance of the designed sensor is analyzed by the coupled-mode theory and transfer matrix method, separately. Here, the simulation results demonstrate that the obtained sensitivity is 17,120 nm/imaginary part unit of refractive index (IP) and the theoretical detection limit is 4.2 × 10−8 IP (regarding carcinoembryonic antigen (CEA), the minimum detection value is 1.78 ng). Instead of the typical diffusion manner, the liquid sample is loaded by convection, which can considerably improve the efficiency of sample capture and shorten the response time of the sensor. The sketched sensor may find potential application in the fields of biomedical detection, environment protection, and drinking water safety.

show abstract

Highly Sensitive Cell Concentration Detection by Resonant Optical Tunneling Effect

Cited by 13 publications

References 47 publications

Photonic Spin Hall Effect as a Highly Sensitive Refractive Index Sensing Platform for Glucose

Photonic Spin Hall Effect as a Highly Sensitive Refractive Index Sensing Platform for Glucose

Recent Advances of Organ-on-a-Chip in Cancer Modeling Research

Biosensing Near the Exceptional Point Based on Resonant Optical Tunneling Effect

Contact Info

Product

Resources

About