Biosensing Near the Exceptional Point Based on Resonant Optical Tunneling Effect

Yang, Liu; Yan, Pengyun; Liu, Feng; Jian, Aoqun; Sang, Shengbo

doi:10.3390/mi12040426

Cited by 6 publications

(4 citation statements)

References 34 publications

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“…A label-free optical biosensor based on optical tunnelling was theoretically suggested in ref. 207. The calculated LOD for the system was found to be 0.9 ng mL −1 .…”

Section: Recent Advancesmentioning

confidence: 91%

Label-free optical biosensing: going beyond the limits

Kabashin,

Kravets,

Grigorenko

2023

Chem. Soc. Rev.

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“…A label-free optical biosensor based on optical tunnelling was theoretically suggested in ref. 207. The calculated LOD for the system was found to be 0.9 ng mL −1 .…”

Section: Recent Advancesmentioning

confidence: 91%

Label-free optical biosensing: going beyond the limits

Kabashin,

Kravets,

Grigorenko

2023

Chem. Soc. Rev.

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“…In [ 97 ], a label-free biosensor for detecting low-concentration analytes has been proposed, via coupled resonant optical-tunnelling resonators (one lossy cavity and one sensing cavity). The behaviour around the EP is controlled by adjusting the separation between the resonators (thus the coupling strength).…”

Section: Sensing Applications Of Non-hermitian Photonicsmentioning

confidence: 99%

Non-Hermitian Sensing in Photonics and Electronics: A Review

Carlo

Leonardis

Soref

et al. 2022

Sensors

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Recently, non-Hermitian Hamiltonians have gained a lot of interest, especially in optics and electronics. In particular, the existence of real eigenvalues of non-Hermitian systems has opened a wide set of possibilities, especially, but not only, for sensing applications, exploiting the physics of exceptional points. In particular, the square root dependence of the eigenvalue splitting on different design parameters, exhibited by 2 × 2 non-Hermitian Hamiltonian matrices at the exceptional point, paved the way to the integration of high-performance sensors. The square root dependence of the eigenfrequencies on the design parameters is the reason for a theoretically infinite sensitivity in the proximity of the exceptional point. Recently, higher-order exceptional points have demonstrated the possibility of achieving the nth root dependence of the eigenfrequency splitting on perturbations. However, the exceptional sensitivity to external parameters is, at the same time, the major drawback of non-Hermitian configurations, leading to the high influence of noise. In this review, the basic principles of PT-symmetric and anti-PT-symmetric Hamiltonians will be shown, both in photonics and in electronics. The influence of noise on non-Hermitian configurations will be investigated and the newest solutions to overcome these problems will be illustrated. Finally, an overview of the newest outstanding results in sensing applications of non-Hermitian photonics and electronics will be provided.

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“…Compared with the WGM resonator, the resonant optical tunneling effect (ROTE) resonator is a rectangular resonant cavity with a particular multilayer dielectric structure [21]. The ROTE is derived from the optical phenomenon of frustrated total internal reflection (FTIR), which was first discovered and named by Pochi Yeh [22].…”

Section: Introductionmentioning

confidence: 99%

A Silicon-Based ROTE Sensor for High-Q and Label-Free Carcinoembryonic Antigen Detection

Sang,

Liang,

Zhao

et al. 2024

Micromachines

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This paper presents a biosensor based on the resonant optical tunneling effect (ROTE) for detecting a carcinoembryonic antigen (CEA). In this design, sensing is accomplished through the interaction of the evanescent wave with the CEA immobilized on the sensor’s surface. When CEA binds to the anti-CEA, it alters the effective refractive index (RI) on the sensor’s surface, leading to shifts in wavelength. This shift can be identified through the cascade coupling of the FP cavity and ROTE cavity in the same mode. Experimental results further show that the shift in resonance wavelength increases with the concentration of CEA. The biosensor responded linearly to CEA concentrations ranging from 1 to 5 ng/mL with a limit of detection (LOD) of 0.5 ng/mL and a total Q factor of 9500. This research introduces a new avenue for identifying biomolecules and cancer biomarkers, which are crucial for early cancer detection.

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Biosensing Near the Exceptional Point Based on Resonant Optical Tunneling Effect

Cited by 6 publications

References 34 publications

Label-free optical biosensing: going beyond the limits

Label-free optical biosensing: going beyond the limits

Non-Hermitian Sensing in Photonics and Electronics: A Review

A Silicon-Based ROTE Sensor for High-Q and Label-Free Carcinoembryonic Antigen Detection

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