Label-free optical biosensing: going beyond the limits

Kabashin, Andrei V.; Kravets, Vasyl G.; Grigorenko, Alexander N.

doi:10.1039/d3cs00155e

Cited by 14 publications

(7 citation statements)

References 218 publications

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“…In comparison with the conventional TMOKE measurements, the maximum values of the spatially resolved TMOKE( x ) are 2.6 times superior. Our findings can improve the functionality of magnetoplasmonic devices operating as sensors − and light modulators. − The spatially resolved magneto-optical effects associated with the GH shift can also be revealed in a wide range of nanophotonic devices such as magnetophotonic crystals, , plasmonic, , and low-loss all-dielectric metasurfaces. − Moreover, the observation of the GH shift can additionally boost the nonlinear magneto-optical, − ultrafast magnetoplasmonic, − and magnetoacoustic effects. , …”

Section: Discussionmentioning

confidence: 81%

Goos–Hänchen Shift Spatially Resolves Magneto-Optical Kerr Effect Enhancement in Magnetoplasmonic Crystals

Makarova,

Nerovnaya,

Gulkin

et al. 2024

ACS Photonics

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We report on how observation of the Goos−Hanchen (GH) shift can be used to spatially resolve the transverse magneto-optical Kerr effect (TMOKE) enhancement in all-nickel magnetoplasmonic crystals (MPCs). First, the excitation of surface plasmons in the MPCs leads to a 15.3 μm (18λ) GH shift. Then, in the presence of a transverse magnetic field, the modulation of the lateral spatial intensity distribution of the reflected light [TMOKE(x)], caused by the GH shift, reaches 4.7% in the experiment. The spatially resolved TMOKE(x) values are several times higher compared to those from conventional TMOKE measurements in the MPCs. The concept of the spatially resolved magneto-optical effects under GH shift can be further extended to other magnetophotonic nanodevices for additional enhancing magneto-optical effects, sensing, and light modulation applications.

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Section: Discussionmentioning

confidence: 81%

Goos–Hänchen Shift Spatially Resolves Magneto-Optical Kerr Effect Enhancement in Magnetoplasmonic Crystals

Makarova,

Nerovnaya,

Gulkin

et al. 2024

ACS Photonics

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“…At the heart of all this technology are plasmonic nanoparticles (NPs), generally gold NPs (Au NPs) [1]. Surface chemistry flexibility allows the binding of diverse molecules to the NP’s surface, acting the NP as a vehicle for biomolecules such as antibodies [2] and allowing the NPs to play a significant role in nanophotonic biosensing [3, 4].…”

Section: Figurementioning

confidence: 99%

“…At the heart of all this technology are plasmonic nanoparticles (NPs), generally gold NPs (Au NPs), 1 since diverse biomolecules can bind to the Au NP’s surface, serving as a vehicle for antibodies 2 and allowing nanophotonic biosensing. 3,4…”

Section: Figurementioning

confidence: 99%

Lateral Flow Assays Biotesting by Utilizing Plasmonic Nanoparticles Made of Inexpensive Metals – Replacing Colloidal Gold

Lorca,

Ávalos-Ovando,

Sikeler

et al. 2024

Preprint

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Different kinds of nanoparticles can be conjugated with diverse biomolecular receptors and employed in biosensing to detect a target analyte (biomarkers of infections, cancer markers, etc.) from biological samples. This proven concept was largely used during the COVID-19 pandemic in over-the-counter gold nanoparticles-based paper strip tests. Considering that gold is expensive and is being largely depleted, here we show that novel and less expensive plasmonic counterparts, titanium nitride (TiN) nanoparticles, and copper nanoparticles covered with a gold shell (Cu@Au) perform comparable or better than gold nanoparticles. After functionalization, these novel nanoparticles provide a high signal, efficiency, and specificity when used on paper strip tests. This allows an easy visual determination of the positive signal and the development of more affordable paper-based test strips. Moreover, by conducting the machine learning study, we have shown that the bio-detection with TiN is more accurate than that with gold, demonstrating the advantage of a broadband plasmonic material. The implementation of lateral flow assays based on TiN and Cu@Au nanoparticles promises a drastic cost reduction of this technology and its widespread applications in tasks of biomedical diagnostics, environmental and food safety, security and doping screening.

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“…At the heart of all this technology are plasmonic nanoparticles (NPs), generally gold NPs (Au NPs), 1 since diverse biomolecules can bind to the Au NPs' surface, serving as a vehicle for antibodies 2 and allowing nanophotonic biosensing. 3,4 Additional to the Au-NP-based COVID-19 tests market, 5−7 colorimetric testing systems for other biomarkers and biomolecules are also commercialized in the so-called lateralflow assays (LFAs). 8−10 LFAs are an inexpensive, quick, and reliable way of analyzing diverse biomarkers such as for pregnancy, diabetes, and strokes, among many others (see Figure 1A).…”

mentioning

confidence: 99%

“…Nanotechnology and nanomaterials could help, since they represent a still fully undiscovered frontier of novel potential uses applicable to advanced medical treatments, for both diagnostics and therapy. At the heart of all this technology are plasmonic nanoparticles (NPs), generally gold NPs (Au NPs), since diverse biomolecules can bind to the Au NPs’ surface, serving as a vehicle for antibodies and allowing nanophotonic biosensing. , …”

mentioning

confidence: 99%

Lateral Flow Assay Biotesting by Utilizing Plasmonic Nanoparticles Made of Inexpensive Metals─Replacing Colloidal Gold

Bahamondes Lorca,

Ávalos-Ovando,

Sikeler

et al. 2024

Nano Lett.

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Nanoparticles (NPs) can be conjugated with diverse biomolecules and employed in biosensing to detect target analytes in biological samples. This proven concept was primarily used during the COVID-19 pandemic with gold-NP-based lateral flow assays (LFAs). Considering the gold price and its worldwide depletion, here we show that novel plasmonic NPs based on inexpensive metals, titanium nitride (TiN) and copper covered with a gold shell (Cu@Au), perform comparable to or even better than gold nanoparticles. After conjugation, these novel nanoparticles provided high figures of merit for LFA testing, such as high signals and specificity and robust naked-eye signal recognition. Since the main cost of Au NPs in commercial testing kits is the colloidal synthesis, our development with the Cu@Au and the laser-ablation-fabricated TiN NPs is exciting, offering potentially inexpensive plasmonic nanomaterials for various bioapplications. Moreover, our machine learning study showed that biodetection with TiN is more accurate than that with Au.

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Label-free optical biosensing: going beyond the limits

Abstract: We present newly-emerging approaches to unlock sensitivity barriers of current label-free optical biosensing transducers by employing novel structural architectures, artificial materials (metamaterials), and newly-observed optical phenomena.

Cited by 14 publications

References 218 publications

Goos–Hänchen Shift Spatially Resolves Magneto-Optical Kerr Effect Enhancement in Magnetoplasmonic Crystals

Goos–Hänchen Shift Spatially Resolves Magneto-Optical Kerr Effect Enhancement in Magnetoplasmonic Crystals

Lateral Flow Assays Biotesting by Utilizing Plasmonic Nanoparticles Made of Inexpensive Metals – Replacing Colloidal Gold

Lateral Flow Assay Biotesting by Utilizing Plasmonic Nanoparticles Made of Inexpensive Metals─Replacing Colloidal Gold

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