Highly Sensitive and Validated Spectrophotometric Technique for the Assay of Some Antidepressant Drugs

Deepakumari, H. N.; Prashanth, M.K.; Kumar, B. C. Vasantha; Revanasiddappa, H. D.

doi:10.1007/s10812-015-0042-y

Cited by 9 publications

(4 citation statements)

References 26 publications

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“…Moreover, for the methods described in our work, color is generated by the direct reaction of the TCA donor with the p-benzoquinone acceptor, whereas other published methods quantify TCAs in an indirect manner, relying on deliberately added dyes that are partially bleached by the excess of a reagent not consumed in a direct reaction with the antidepressant [67,68].…”

Section: Comparison With Other Spectrophotometric Methods Published I...mentioning

confidence: 99%

Development of Visible Spectrophotometric Methods for the Determination of Tricyclic Antidepressants Based on Formation of Molecular Complexes with p-Benzoquinones

Ciuca,

Racovita

2023

IJMS

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Tricyclic antidepressants are commonly employed in the management of major depressive disorders. The present work describes two visible (VIS) spectrophotometric techniques that utilize the formation of charge transfer complexes between four antidepressant compounds, namely, amitriptyline hydrochloride (AMI), imipramine hydrochloride (IMI), clomipramine hydrochloride (CLO), and trimipramine maleate (TRI) acting as electron donors and two p-benzoquinones, namely, p-chloranilic acid (pCA) and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), serving as electron acceptors. The stoichiometry of the compounds produced exhibited a consistent 1:1 ratio in all instances, as established by Job’s method. Molar absorptivities, equilibrium association constants, and several other spectroscopic properties were determined for all complexes. The developed spectrophotometric techniques were validated intra-laboratory and successfully applied for quantitative assessment of the four antidepressant active ingredients in several commercial pharmaceutical formulations. The methods are relatively simple, fast, and use readily available laboratory instrumentation, making them easily applicable by most quality control laboratories worldwide.

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Section: Comparison With Other Spectrophotometric Methods Published I...mentioning

confidence: 99%

Development of Visible Spectrophotometric Methods for the Determination of Tricyclic Antidepressants Based on Formation of Molecular Complexes with p-Benzoquinones

Ciuca,

Racovita

2023

IJMS

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“…39,40 It is notable that the most utilized analytical procedures to detect desipramine relied on gas and liquid chromatography, 41,42 electrophoresis, 43 and spectrophotometry. 44 However, detecting desipramine via the above methods showed higher sensitivity. However, they require costly tools, laborious pretreatment phases, trained operators, and multiple organic solvents.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of magnetic iron oxide-supported copper oxide nanoparticles (Fe₃O₄/CuO): modified screen-printed electrode for electrochemical studies and detection of desipramine

et al. 2020

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“…Owing to the vital importance of CLP.HCl, the development of a newly fast, sensitive and selective method for its detection is of crucial significance. Although, numerous analytical techniques have been studied for CLP.HCl detection including HPLC (high performance liquid chromatography) [4, 5], spectrophotometry [6, 7], Liquid chromatography‐tandem mass spectrometry [8–10], fabric phase sorptive extraction method‐HPLC [11], continuous liquid‐phase microextraction‐HPLC [12] and HPLC‐resonance Rayleigh scattering spectra [13]. However, most of these methods are unsuitable for rapid, cost‐effective and on‐site measurements due to the need of costive sophisticated apparatus, time‐consuming and tedious sample preparation and pre‐treatment procedures.…”

Section: Introductionmentioning

confidence: 99%

Hybrid Nanocomposite Based Graphene Sensor for Ultrasensitive Clomipramine HCl Detection

et al. 2021

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A potentiometric sensor modified with a nanocomposite of montmorillonite sheets decorated with polyaniline nanofibers (MT‐PANI‐NFs) as an efficient electroactive material and tricresyl phosphate (TCP) as a solvent mediator has been developed for the estimation of clomipramine HCl (CLP.HCl). The optimum potentiometric performance of the sensor was achieved by mixing of MT‐PANI‐NFs : TCP : graphene with a ratio of 2.69 : 30.11 : 67.20 (% wt/wt). The sensor exhibited a Nernstian slope of 59.0±0.1 mV decade−1 over the concentration range of 1.0×10−5−1.0×10−2 mol L−1 with a theoretically calculated detection limit of 5.0×10−6 mol L−1. The sensor performance was scrutinized in terms of several factors including thermal stability, pH effect, response time and selectivity. As, it displayed a high thermal stability at various temperature degrees (10–60 °C) with pH independency in the range of 3.5–8.5. Additionally, the developed sensor exhibited a very rapid performance for CLP.HCl detection with a fast response time of 4 s and reflecting a superior selectivity towards CLP.HCl over the other interfering species. SEM (scanning electron microscope) was used as a characteristic tool for the investigation of the proposed graphene sensor surface. Furthermore, the graphene sensor has been efficiently used for CLP.HCl estimation in its pharmaceutical formulations.

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Highly Sensitive and Validated Spectrophotometric Technique for the Assay of Some Antidepressant Drugs

Cited by 9 publications

References 26 publications

Development of Visible Spectrophotometric Methods for the Determination of Tricyclic Antidepressants Based on Formation of Molecular Complexes with p-Benzoquinones

Development of Visible Spectrophotometric Methods for the Determination of Tricyclic Antidepressants Based on Formation of Molecular Complexes with p-Benzoquinones

Fabrication of magnetic iron oxide-supported copper oxide nanoparticles (Fe₃O₄/CuO): modified screen-printed electrode for electrochemical studies and detection of desipramine

Hybrid Nanocomposite Based Graphene Sensor for Ultrasensitive Clomipramine HCl Detection

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Highly Sensitive and Validated Spectrophotometric Technique for the Assay of Some Antidepressant Drugs

Cited by 9 publications

References 26 publications

Development of Visible Spectrophotometric Methods for the Determination of Tricyclic Antidepressants Based on Formation of Molecular Complexes with p-Benzoquinones

Development of Visible Spectrophotometric Methods for the Determination of Tricyclic Antidepressants Based on Formation of Molecular Complexes with p-Benzoquinones

Fabrication of magnetic iron oxide-supported copper oxide nanoparticles (Fe3O4/CuO): modified screen-printed electrode for electrochemical studies and detection of desipramine

Hybrid Nanocomposite Based Graphene Sensor for Ultrasensitive Clomipramine HCl Detection

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Fabrication of magnetic iron oxide-supported copper oxide nanoparticles (Fe₃O₄/CuO): modified screen-printed electrode for electrochemical studies and detection of desipramine