Highly Sensitive and Selective Voltammetric Sensor Fullerene Modified Glassy Carbon Electrode for Determination of Cefitizoxime in Solubilized System

Abstract

The usefulness of fullerene modified glassy carbon electrode in mediating the reduction of cefitizoxime in solubilized system has been demonstrated. Due to the unique structure and extraordinary properties, fullerene shows higher catalytic efficiency towards cefitizoxime reduction. The kinetic parameters, electron transfer coefficient (a) and rate constant (K 0 ) across the modified electrode are 0.37 and 0.1081/s respectively. The proposed square-wave voltammetric method is linear over the concentration range 1.2-10.3 mg/mL. The limit of detection (LOD) is found 0.27 ng/mL. High sensitivity and selectivity together with low detection limit of the electrode response make it suitable for the determination of cefitizoxime.

Glassy carbon electrode modified with multi-walled carbon nanotubes sensor for the quantification of antihistamine drug pheniramine in solubilized systems

“…Carbon nanotubes (CNTs) are most important nanomaterials due to their high mechanical strength [9] , high surface area [10] and high chemical stability [11] . Multi-walled carbon nanotubes (MWCNTs) are now considered important modifiers due to their ability to promote electron transfer in electrochemical reactions, improve sensitivity and chemical inertness [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , other modifier and different types of surfactants are also used for electrochemical studies [20] , [21] , [22] , [23] , [24] , [25] . In this study, glassy carbon electrode modified with multi-walled carbon nanotubes (GCE-MWCNTs) was fabricated to improve the limit of detection.…”

Bioelectroanalysis of pharmaceutical compounds

“…to modify carbon electrodes. Examples are fullerenemodified glassy carbon electrodes for the determination of atenolol [19], methylprednisolone [268] and cefitizoxime [269], graphite electrodes for dexamethasone [270] and graphite electrodes together with CNT for triamcinolone [271]. Fullerene-modified gold electrodes have been employed for prednisolone [272] and for dopamine in the presence of ascorbic acid [273].…”

GaN doped C60 as a nano bio sensor for the detection of mispairing in adenine-thymine base pair

“…Electrochemical biosensors have also been fabricated by metallic nanoparticles [43]. Carbon nanotubes, graphene, fullerenes (C 60 ) and their derivatives are another class of promising nanomaterials, which have been used in many chemical and biosensors [44][45][46]. In the present communication, we have been using GaN modified C 60 to distinguish the AT base pair from the rAT base pair.…”