Highly selective solid phase extraction and preconcentration of Azathioprine with nano-sized imprinted polymer based on multivariate optimization and its trace determination in biological and pharmaceutical samples

Davarani, Saied Saeed Hosseiny; Zad, Zeinab Rezayati; Taheri, Alireza; Rahmatian, Nasrin

doi:10.1016/j.msec.2016.09.075

Cited by 23 publications

(7 citation statements)

References 29 publications

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“…For the electron donating groups, Knoevenagel and Debner modification reactions lead to the good yields of the final product but the main drawback is that reaction needs long duration of time. Phosphorus oxychloride (POC) act as acid catalyst, which activate both reaction components, since interaction of the aldehydes component with POC may produce the active carbocation [19].…”

Section: Phosphorous Oxychloride Methodsmentioning

confidence: 99%

Synthetic methods and pharmacological potential of some cinnamic acid analogues particularly against convulsions

Asif

Imran

2019

Prog. Chem. Biochem. Res.

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Section: Phosphorous Oxychloride Methodsmentioning

confidence: 99%

Synthetic methods and pharmacological potential of some cinnamic acid analogues particularly against convulsions

Asif

Imran

2019

Prog. Chem. Biochem. Res.

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“…Similar to the situation in the pre-polymerization mixture, the possible combinations of experimental parameters (e.g., analyte concentration, solvent, pH, temperature, flow rate, incubation time) are nearly endless, making this an area highly suited for multivariate optimization. Thus, different combinations of experimental designs and response surface modeling have been used for optimization of parameters when using MIPs in adsorption, separation or sensing applications [ 214 , 267 , 375 , 467 , 468 , 470 , 475 , 476 , 477 , 520 , 521 , 522 , 523 , 524 , 525 , 526 , 527 , 528 , 529 , 530 , 531 , 532 , 533 , 534 , 535 , 536 , 537 , 538 , 539 , 540 , 541 , 542 , 543 , 544 , 545 , 546 , 547 , 548 , 549 , 550 , 551 , 552 , 553 , 554 , 555 , 556 , 557 , …”

Section: Mip Structure and Functionmentioning

confidence: 99%

The Use of Computational Methods for the Development of Molecularly Imprinted Polymers

et al. 2021

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Recent years have witnessed a dramatic increase in the use of theoretical and computational approaches in the study and development of molecular imprinting systems. These tools are being used to either improve understanding of the mechanisms underlying the function of molecular imprinting systems or for the design of new systems. Here, we present an overview of the literature describing the application of theoretical and computational techniques to the different stages of the molecular imprinting process (pre-polymerization mixture, polymerization process and ligand–molecularly imprinted polymer rebinding), along with an analysis of trends within and the current status of this aspect of the molecular imprinting field.

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“…NanoMIPs were successfully employed as the SPE adsorbent for selective separation purposes. 8 Optical sensors based on fluorescent nanoMIPs were also created to detect the analyte via a reduction in fluorescence emission intensity 9 or fluorescence resonance energy transfer. 10 In another study, a nanoMIP sensor using surface plasmon resonance was successfully developed.…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted polymer nanoparticles for the recognition of ellagic acid

Yucel

Gulen

Hatir

2022

J of Applied Polymer Sci

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Ellagic acid (EA) is one of the bioactive polyphenolic flavonoids found in many fruits. Over the years, various extraction methods have been developed to isolate pure EA from plant samples. These methods, however, have some disadvantages, such as low specificity and selectivity, not easy incorporation into industrial processes, and low‐purification efficiency. The present study proposes an approach based on the molecular imprinting technique. We describe the nanoscale production of EA imprinted polymers for the first time. We develop a straightforward, efficient, and environmentally friendly precipitation polymerization method to synthesize molecularly imprinted polymer nanoparticles (nanoMIPs). To increase the affinity of nanoMIPs, we explore molecular interactions between EA and functional monomers before polymerization. The nanoMIPs are successfully synthesized with an excellent yield of 94.5%. The maximum binding capacity is 66.6 and 45.6 μmol/g for EA imprinted and nonimprinted polymers, respectively. Furthermore, in the presence of quercetin, an EA analog, and other compounds in the pomegranate peel extract solution, nanoMIPs selectively retain EA. NanoMIPs will be a valuable analytical tool for separation and sensing applications, especially dispersive solid‐phase extraction.

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Highly selective solid phase extraction and preconcentration of Azathioprine with nano-sized imprinted polymer based on multivariate optimization and its trace determination in biological and pharmaceutical samples

Cited by 23 publications

References 29 publications

Synthetic methods and pharmacological potential of some cinnamic acid analogues particularly against convulsions

Synthetic methods and pharmacological potential of some cinnamic acid analogues particularly against convulsions

The Use of Computational Methods for the Development of Molecularly Imprinted Polymers

Molecularly imprinted polymer nanoparticles for the recognition of ellagic acid

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