“…The 1,3-diol moiety is present in a number of natural products including polyene macrolide antibiotics, and has some biological activity . A number of conventional methods for the preparation of 1,3-diols have been developed, including: (1) reduction of β-diketones or β-hydroxy ketones, , (2) reduction of α-hydroxy epoxides, (3) radical-mediated C−H functionalization, (4) highly selective reduction of acyclic β-alkoxy ketones, and (5) silylmethyl radical cyclization of allylic alcohols . Symmetrical and asymmetrical 1,3-diols can be obtained through the first two methods and last three methods, respectively.…”