Highly oxygenated antiausterity agents from the leaves of Uvaria dac

Bioassay-Guided Isolation and HPLC Quantification of Antiproliferative Metabolites from Stahlianthus thorelii

“…Although the remaining compounds 4-6 displayed moderate activities on different cell lines, this study was the first to report antiproliferation on four tumor cell lines for 4 and 5. In previous reports, 4 ((+)-crotepoxide) showed antimutagenicity in a Vitotox assay [17] and 1,6-deoxytingtanoxide (5) displayed mild cytotoxicity against human pancreatic cancer cell lines [21]. The bioassay data showed that compound 6 (O-methoxybenzoyl benzoate) did not have significant cytotoxicity on MCF-7; this result correlated with a previous study [22].…”

Structure elucidation of cyclohexene (9Z)-octadec-9-enyl ethers isolated from the leaves of Uvaria cherrevensis (Annonaceae)

“…The leaf extracts of U. cherrevensis were subjected to chromatographic separation techniques which led to the isolation and characterization of three new compounds, cherrevenols M-O (1)(2)(3), and a known compound, dulcisene A (4) ( Figure 1). 2 Cherrevenol M (1) was obtained as a white amorphous solid.…”

“…2 Previous studies on U. cherrevensis, Annonaceae family, found various types of secondary metabolites, including alkaloids, cyclohexenes, flavonoids, naphthalene derivatives, and terpenoids. [3][4][5][6][7][8] We report here the first isolation of cyclohexene (9Z)-octadec-9-enyl ethers, cherrevenols M-O (1)(2)(3), from the leaf extracts of U. cherrevensis. The application of 13 C NMR and Ozone Induced Dissociation (OzID) mass spectrometry were used to determine the (Z) configuration and C-9 position of the olefinic moiety of the C-18 ether side chains, respectively.…”

“…Cyclohexene long-chain saturated fatty esters were isolated in earlier studies from two species of Uvaria, U. dulcis and U. dac. 1,2 These compounds exhibited cytotoxic activities. 2 Previous studies on U. cherrevensis, Annonaceae family, found various types of secondary metabolites, including alkaloids, cyclohexenes, flavonoids, naphthalene derivatives, and terpenoids.…”

(R)-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of Anomianthus dulcis and their antimalarial and cytotoxic activities

“…The crude extract and some secondary metabolites from this plant showed antibacterial (Ubonopas et al 2014;Kadchumsang et al 2015), anticancer, anti-Herpes Simplex Virus I (Ubonopas et al 2014), antispasmodic, (Wiya et al 2018) and antioxidant activities (Kadchumsang et al 2015). Furthermore, previous investigations of plants from the Uvaria genus have found several types of secondary metabolites such as polyoxygenated cyclohexenes (Ho et al 2015;Okpekon et al 2015;Hsu et al 2016;Auranwiwat et al 2017;Awale et al 2017;Auranwiwat et al 2019a;Auranwiwat et al 2019b), flavonoids (Salae et al 2017;Auranwiwat et al 2018), alkaloids (Auranwiwat et al 2018), naphthalenes (Auranwiwat et al 2017;Salae et al 2017), xanthenes (Macabeo et al 2014) and lignan glycosides (Nguyen et al 2015). Some of these chemical constituents have shown significant bioactivities, including anticancer (Macabeo et al 2014;Ho et al 2015;Awale et al 2017), anti-inflammatory (Hsu et al 2016), antimalarial (Auranwiwat et al 2017;Salae et al 2017), antimicrobial (Okpekon et al 2015), antiglycation and antioxidant activities (Thomas and Essien 2018).…”