Highly monodispersed gold nanoparticles synthesis and inhibition of herpes simplex virus infections

Halder, Asim; Das, Suvadra; Ojha, Durbadal; Chattopadhyay, Debprasad; Mukherjee, Arup

doi:10.1016/j.msec.2018.04.005

Cited by 88 publications

(56 citation statements)

References 31 publications

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“…Especially, it has been reported that the silver-thiol interaction between HA disulfide bonds and silver nanoparticles (AgNPs) could inhibit IV infection by cleaving disulfide bonds [16][17][18]. Therefore, various modifications of noble metallic nanoparticles have been tested to mitigate viral infection, i.e., tannic acid-modified silver nanoparticle [19], silver nanoparticle/chitosan composite [20], curcumin-modified silver nanoparticle [21], PVP-coated silver nanoparticle [22,23] multivalent gold nanoparticles [24][25][26][27] and gallic acid-functionalized gold nanoparticle [28]. These noble metal-based nanoparticles suppressed viral infection by blocking viral entry to the host cell.…”

Section: Introductionmentioning

confidence: 99%

Porous gold nanoparticles for attenuating infectivity of influenza A virus

et al. 2020

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Background: Influenza viruses (IVs) have become increasingly resistant to antiviral drugs that target neuraminidase and matrix protein 2 due to gene mutations that alter their drug-binding target protein regions. Consequently, almost all recent IV pandemics have exhibited resistance to commercial antiviral vaccines. To overcome this challenge, an antiviral target is needed that is effective regardless of genetic mutations. Main body:In particular, hemagglutinin (HA), a highly conserved surface protein across many IV strains, could be an effective antiviral target as it mediates binding of IVs with host cell receptors, which is crucial for membrane fusion. HA has 6 disulfide bonds that can easily bind with the surfaces of gold nanoparticles. Herein, we fabricated porous gold nanoparticles (PoGNPs) via a surfactant-free emulsion method that exhibited strong affinity for disulfide bonds due to gold-thiol interactions, and provided extensive surface area for these interactions. A remarkable decrease in viral infectivity was demonstrated by increased cell viability results after exposing MDCK cells to various IV strains (H1N1, H3N2, and H9N2) treated with PoGNP. Most of all, the viability of MDCK cells infected with all IV strains increased to 96.8% after PoGNP treatment of the viruses compared to 33.9% cell viability with non-treated viruses. Intracellular viral RNA quantification by real-time RT-PCR also confirmed that PoGNP successfully inhibited viral membrane fusion by blocking the viral entry process through conformational deformation of HA. Conclusion:We believe that the technique described herein can be further developed for PoGNP-utilized antiviral protection as well as metal nanoparticle-based therapy to treat viral infection. Additionally, facile detection of IAV can be achieved by developing PoGNP as a multiplatform for detection of the virus.

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Section: Introductionmentioning

confidence: 99%

Porous gold nanoparticles for attenuating infectivity of influenza A virus

et al. 2020

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“…Apart from considerable contributions in biochemistry, gold nanoparticles also possess the display effect on pathogens, fungi and viruses. For instance, Chattopadhyay et al have prepared highly mono-dispersed quasi spherical gold-nanoparticles and used them to inhibit herpes simplex viruses [71]. Using an ultrasonic strategy, gallic acid was modified onto the surface of the monodispersed gold nanoparticles and used as a stabilizer for gold nanoparticle spheres.…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

An overview of functional nanoparticles as novel emerging antiviral therapeutic agents

Chen

Liang

2020

Materials Science and Engineering: C

195

154

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Research on highly effective antiviral drugs is essential for preventing the spread of infections and reducing losses. Recently, many functional nanoparticles have been shown to possess remarkable antiviral ability, such as quantum dots, gold and silver nanoparticles, nanoclusters, carbon dots, graphene oxide, silicon materials, polymers and dendrimers. Despite their difference in antiviral mechanism and inhibition efficacy, these functional nanoparticles-based structures have unique features as potential antiviral candidates. In this topical review, we highlight the antiviral efficacy and mechanism of these nanoparticles. Specifically, we introduce various methods for analyzing the viricidal activity of functional nanoparticles and the latest advances in antiviral functional nanoparticles. Furthermore, we systematically describe the advantages and disadvantages of these functional nanoparticles in viricidal applications. Finally, we discuss the challenges and prospects of antiviral nanostructures. This topic review covers 132 papers and will enrich our knowledge about the antiviral efficacy and mechanism of various functional nanoparticles.

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“…1 Among them, many are applied in antiviral research, 2 such as macromolecular copolymers (peptide-polymer conjugates), fullerene-polyglycerol sulfates, metal nanoparticles (NPs) (e.g., AgNPs and AuNPs) and quantum dots. [3][4][5][6][7][8][9][10] However, the complexity of synthetic methods (e.g., macromolecular copolymers), the cytotoxicity of degradation products (e.g., precious metal NPs) and the poor stability (e.g., NPs with sheet or ber structures) limit the application of most antiviral NPs to some extent. 4,[11][12][13] Therefore, it is extremely necessary to develop nanomaterials with good biocompatibility and high stability using a simple and fast synthetic method.…”

Section: Introductionmentioning

confidence: 99%