Highly luminescent, biocompatible ytterbium(<scp>iii</scp>) complexes as near-infrared fluorophores for living cell imaging

Ning, Yingying; Tang, Juan; Liu, Yi-Wei; Jing, Jing; Sun, Yuansheng; Zhang, Junlong

doi:10.1039/c8sc00259b

Cited by 104 publications

(83 citation statements)

References 81 publications

(70 reference statements)

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“…The highest quantum yield (54.6 %) was obtained for the terbium complex. The quantum yields obtained for the other visible emitting complexes (0.43–12.0 %) are on par with most ligand sensitized lanthanide emission . In comparison, the quantum yields obtained for the near infrared emitting complexes are low (0.05–0.10 %).…”

Section: Resultsmentioning

confidence: 87%

Solid State Structures, Solution Behavior, and Luminescence of Simple Tetrakis(2‐pyridylmethyl)ethylenediamine Lanthanide Complexes

2019

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We report the synthesis, characterization, solid‐state structure and solution behavior of simple lanthanide trifluoromethanesulfonate complexes supported by a hexadentate tetrakis(2‐pyridylmethyl)ethylenediamine ligand. The complexes' solid‐state structures exhibit different trifluoromethanesulfonate coordination, correlating with the size difference of the lanthanide ions. The ligand is capable of sensitizing Nd, Sm, Eu, Tb, Dy, and Yb yielding metal‐centered emission with moderate quantum yields.

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Section: Resultsmentioning

confidence: 87%

Solid State Structures, Solution Behavior, and Luminescence of Simple Tetrakis(2‐pyridylmethyl)ethylenediamine Lanthanide Complexes

2019

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“…13,20,[32][33][34] Changes in emission lifetimes can give indications on O 2 concentration in cells, [35][36][37] colocalization with a FRET (Förster resonance energy transfer) acceptor, 34 and changes in polarity, viscosity or lipophilicity. 38…”

Section: Imaging Techniquesmentioning

confidence: 99%

Lanthanide-based tools for the investigation of cellular environments

et al. 2018

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Biological probes constructed from lanthanides can provide a variety of readout signals, such as the luminescence of Eu(iii), Tb(iii), Yb(iii), Sm(iii) and Dy(iii), and the proton relaxation enhancement of Gd(iii) and Eu(ii). For numerous applications the intracellular delivery of the lanthanide probe is essential. Here, we review the methods for the intracellular delivery of non-targeted complexes (i.e. where the overall complex structure enhances cellular uptake), as well as complexes attached to a targeting unit (i.e. to a peptide or a small molecule) that facilitates delivery. The cellular applications of lanthanide-based supramolecules (dendrimers, metal organic frameworks) are covered briefly. Throughout, we emphasize the techniques that can confirm the intracellular localization of the lanthanides and those that enable the determination of the fate of the probes once inside the cell. Finally, we highlight methods that have not yet been applied in the context of lanthanide-based probes, but have been successful in the intracellular delivery of other metal-based probes.

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“…However, light absorption ability of Yb 3+ itself is significantly smaller (ε = 1–100 dm 3 mol −1 cm −1 ) than that of organic dyes (ε = 10 4 –10 5 dm 3 mol −1 cm −1 ) because the electronic transitions of lanthanide ions are electric dipole forbidden (Laporte forbidden) transitions . To enhance NIR emission of Yb 3+ , sensitization, namely energy transfer from suitable donors with high absorption coefficient (as in this study) in colloidal nanocrystals (e.g., Cd or Pb chalcogenide) and in the form of Yb 3+ complexes with organic ligands, have been attempted so far . Unfortunately, their NIR PLQYs were still much small (<≈10%) compared to visible light emitting analogues, which prevents practical applications for NIR optoelectric devices.…”

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confidence: 83%

Sensitized Yb³⁺ Luminescence in CsPbCl₃ Film for Highly Efficient Near‐Infrared Light‐Emitting Diodes

Ishii

Miyasaka

2020

Advanced Science

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Near‐infrared (NIR) light emitting diodes (LEDs) with the emission wavelength over 900 nm are useful in a wide range of optical applications. Narrow bandgap NIR emitters have been widely investigated using organic compounds and colloidal quantum dots. However, intrinsically low charge mobility and luminescence efficiency of these materials limit improvement of the external quantum efficiency (EQE) of NIR LEDs, which is far from practical applications. Herein, a highly efficient NIR LED is demonstrated, which is based on an energy transfer from wide bandgap all inorganic perovskite (CsPbCl3) to ytterbium ions (Yb3+) as an NIR emitter doped in the perovskite crystalline film. High mobility of electrically excited carriers in the perovskite crystalline film provides a long carrier diffusion and enhances radiative recombination of an emission center due to minimized charge trapping losses, resulting in high EQE value in LEDs. The NIR emission of Yb3+ at around 1000 nm is found to be sensitized by CsPbCl3 thin film with a photoluminescence quantum yield over 60%. The LED based on Yb3+‐doped CsPbCl3 film exhibits a high EQE of 5.9% with a peak wavelength of 984 nm, achieved by high carrier transporting ability and effective sensitized emission property in the solid‐film structure.

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Highly luminescent, biocompatible ytterbium(iii) complexes as near-infrared fluorophores for living cell imaging

Cited by 104 publications

References 81 publications

Solid State Structures, Solution Behavior, and Luminescence of Simple Tetrakis(2‐pyridylmethyl)ethylenediamine Lanthanide Complexes

Solid State Structures, Solution Behavior, and Luminescence of Simple Tetrakis(2‐pyridylmethyl)ethylenediamine Lanthanide Complexes

Lanthanide-based tools for the investigation of cellular environments

Sensitized Yb³⁺ Luminescence in CsPbCl₃ Film for Highly Efficient Near‐Infrared Light‐Emitting Diodes

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Highly luminescent, biocompatible ytterbium(iii) complexes as near-infrared fluorophores for living cell imaging

Cited by 104 publications

References 81 publications

Solid State Structures, Solution Behavior, and Luminescence of Simple Tetrakis(2‐pyridylmethyl)ethylenediamine Lanthanide Complexes

Solid State Structures, Solution Behavior, and Luminescence of Simple Tetrakis(2‐pyridylmethyl)ethylenediamine Lanthanide Complexes

Lanthanide-based tools for the investigation of cellular environments

Sensitized Yb3+ Luminescence in CsPbCl3 Film for Highly Efficient Near‐Infrared Light‐Emitting Diodes

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Sensitized Yb³⁺ Luminescence in CsPbCl₃ Film for Highly Efficient Near‐Infrared Light‐Emitting Diodes