Highly fluorescent lipophilic 2,1,3-benzothiadiazole fluorophores as optical sensors for tagging material and gasoline adulteration with ethanol

Biosensors Based on Graphene Oxide Functionalized with Benzothiadiazole-Derived Ligands for the Detection of Cholesterol

“…The π-conjugated structure of BTD facilitates electron transfer to GO, while the amine or carboxylic acid end groups allow a hydrogen bond or covalent interaction with enzymes . As seen from photophysical studies, BTD associated to GO exhibits intense fluorescence, and this feature can be exploited for the detection of several other molecules, as described in the literature. ,, The results of the present work are compared with other graphene-based biosensors in cholesterol detection (Table S12), and it is possible to note that the limits of our biosensors are very satisfactory, also working at a low detection range, which is very attractive for non-invasive sensors.…”

“…The absorption located around 230 nm is associated with the π → π* transition of the imidazole­(ium) group . The intense absorption band located above 300 nm was attributed to the π → π* transition allowed by spin and symmetry of the BTD chromophore. ,, It was observed that the substitution of imidazole with 1-carboxymethyl produced a hypsochromic shift in the outer bands and a bathochromic shift in the central band. The maximum absorption of BTD-functionalized materials coincided with the absorptions of GO and GO-La (Figures , S9, and S10).…”

Photoactive benzothiadiazole-N-heterocycle derivatives: synthesis, photophysics and water sensing in organic solvents

“…[1][2][3] Several molecules containing the BTD framework have been described as chemosensors for the detection of a wide range of analytes, such as nickel(II), 4,5 fluoride, 6 cobalt(II), 7 cyanide, 8,9 mercury(II), 10 heparin, 11 DNA, 12 and adulterants in gasoline. 13 BTD is a typical electron-withdrawing moiety amenable to facile ring modification and the introduction of such fragments into molecules may facilitate electron injection or charge transport and therefore enable fine-tuning of band gaps. In this sense, BTD-based compounds have found applications in OLEDs, [14][15][16][17][18][19] solar cells, [20][21][22] liquid crystals, [23][24][25] as fluorescent biomarkers, [26][27][28][29][30][31][32][33] and mechanochromic dyes.…”

Sensitive hydrazine detection and quantification with a fluorescent benzothiadiazole sensor: selective lipid droplets andin vivoimaging

“…61,62 Several groups 63–94 have effectively applied new fluorescent BTD derivatives as bioimaging probes to study different biological features. Although desirable physicochemical features, photoproperties, and stabilities are typically noted for fluorescent BTD derivatives, 95–100 to the best of our knowledge, no fluorogenic BTD has been applied as a sensitive and selective sensor for hydrazine detection, especially in live cells and multicellular models ( in vivo applications). Based on our interest in the development and bioimaging application of fluorescent BTDs, 101–108 we disclose herein the design, synthesis, and sensitive hydrazine detection in solution, live cells, and multicellular models using a newly designed fluorescent BTD sensor.…”