Sensitive hydrazine detection and quantification with a fluorescent benzothiadiazole sensor: selective lipid droplets and<i>in vivo</i>imaging

Santos, Camila O. dos; Passos, Saulo T. A.; Sorto, Jenny E. P.; Machado, Daniel F. S.; Corrêa, José R.; Júnior, Eufrânio N. da Silva; Rodrigues, Marcelo O.; Neto, Brenno A. D.

doi:10.1039/d3ob00007a

Org. Biomol. Chem.

2023

DOI: 10.1039/d3ob00007a

|View full text |Cite

Sensitive hydrazine detection and quantification with a fluorescent benzothiadiazole sensor: selective lipid droplets andin vivoimaging

Camila O. dos Santos

Saulo T. A. Passos

Jenny E. P. Sorto

et al.

Abstract: A selective hydrazine sensor in solution based on the 2,1,3-benzothiadiazole heterocycle is efficient for in vitro and in vivo analyses. This sensor generates water as the only byproduct, avoiding generation of toxic compounds and interference during in vivo applications.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article4

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

References 150 publications

(198 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

5‐N,N‐Diarylaminothiazoles with Electron‐Accepting Groups: Synthesis, Photophysical Properties, and Their Application for the Detection of Hydrazine Hydrate

Murai,

Tanaka,

Takekoshi

et al. 2023

Eur J Org Chem

View full text Add to dashboard Cite

Abstract5‐N,N‐diarylaminothiazoles containing cyano and nitro groups were synthesized using the Pd‐catalyzed Buchwald‐Hartwig amination reaction with good yields. The cyano group in the resultant thiazole was reduced to a formyl group. This was then subjected to the Knoevenagel condensation reaction, leading to the formation of thiazoles with a dicyanovinyl group. The nitro group in the thiazole was reduced to an amino group, which was subsequently reacted with triphosgene, yielding a thiazole with an isocyanate group. These thiazoles, with their electron‐accepting properties, demonstrated absorption and emission spectra at longer wavelengths. Notably, the thiazole containing the dicyanovinyl group displayed a red emission. Tests for the detection of hydrazine, a hazardous volatile organic compound, were conducted using the synthesized thiazoles. The results showed that the dicyanovinyl group effectively responded to hydrazine hydrate, evidenced by changes in the absorption and emission spectra. This change in color was also visibly detectable to the naked eye.

show abstract

5‐N,N‐Diarylaminothiazoles with Electron‐Accepting Groups: Synthesis, Photophysical Properties, and Their Application for the Detection of Hydrazine Hydrate

Murai,

Tanaka,

Takekoshi

et al. 2023

Eur J Org Chem

View full text Add to dashboard Cite

show abstract

Phenothiazine-based fluorescent probes for the detection of hydrazine in environment and living cells

Xia,

Wang,

Han

et al. 2024

Talanta

View full text Add to dashboard Cite

Functional chromophores synthesized via multicomponent Reactions: A review on their use as cell-imaging probes

Neto,

Sorto,

Lapis

et al. 2023

Methods

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Sensitive hydrazine detection and quantification with a fluorescent benzothiadiazole sensor: selective lipid droplets andin vivoimaging

Abstract: A selective hydrazine sensor in solution based on the 2,1,3-benzothiadiazole heterocycle is efficient for in vitro and in vivo analyses. This sensor generates water as the only byproduct, avoiding generation of toxic compounds and interference during in vivo applications.

Cited by 4 publications

References 150 publications

5‐N,N‐Diarylaminothiazoles with Electron‐Accepting Groups: Synthesis, Photophysical Properties, and Their Application for the Detection of Hydrazine Hydrate

5‐N,N‐Diarylaminothiazoles with Electron‐Accepting Groups: Synthesis, Photophysical Properties, and Their Application for the Detection of Hydrazine Hydrate

Phenothiazine-based fluorescent probes for the detection of hydrazine in environment and living cells

Functional chromophores synthesized via multicomponent Reactions: A review on their use as cell-imaging probes

Contact Info

Product

Resources

About