Highly fluorescent carbon dots as novel theranostic agents for biomedical applications

Wan, Jiafeng; Zhang, Xiaoyuan; Fu, Kun; Zhang, Xin; Li, Shang; Su, Zhiqiang

doi:10.1039/d1nr03740d

Cited by 40 publications

(34 citation statements)

References 150 publications

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“…CDs show enormous potential as antibacterial agents due to their easy functionalization with antibacterial functional groups or controllable surface charge (Figure 7a). [213][214][215] By controlling the surface charge and functional properties, the affinity, specificity and antibacterial properties of the CDs can be precisely controlled.…”

Section: Antibacterialmentioning

confidence: 99%

Carbon Dots in Bioimaging, Biosensing and Therapeutics: A Comprehensive Review

et al. 2022

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Section: Antibacterialmentioning

confidence: 99%

Carbon Dots in Bioimaging, Biosensing and Therapeutics: A Comprehensive Review

et al. 2022

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“… By attaching biocompatible units, such as peptides, polypeptide and inorganic nanostructures, toxicity of the AIE-active pyrene derivatives can be reduced to be comparable to other therapeutic nanomaterials, such as conjugated polymers, MOFs, carbon-dots, nanoclusters, etc. [ 117 , 118 , 119 , 120 , 121 , 122 ]. Since cell culture is majorly conducted in aqueous environment, the pyrene-based molecules can easily tune their AIE properties at certain water fractions, thereby is effective in bioimaging studies.…”

Section: Design Requirements Advantages and Limitationsmentioning

confidence: 99%

Pyrene-Based AIE Active Materials for Bioimaging and Theranostics Applications

Shellaiah

Sun

2022

Biosensors

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Aggregation-induced emission (AIE) is a unique research topic and property that can lead to a wide range of applications, including cellular imaging, theranostics, analyte quantitation and the specific detection of biologically important species. Towards the development of the AIE-active materials, many aromatic moieties composed of tetraphenylethylene, anthracene, pyrene, etc., have been developed. Among these aromatic moieties, pyrene is an aromatic hydrocarbon with a polycyclic flat structure containing four fused benzene rings to provide an unusual electron delocalization feature that is important in the AIE property. Numerous pyrene-based AIE-active materials have been reported with the AIE property towards sensing, imaging and theranostics applications. Most importantly, these AIE-active pyrene moieties exist as small molecules, Schiff bases, polymers, supramolecules, metal-organic frameworks, etc. This comprehensive review outlines utilizations of AIE-active pyrene-based materials on the imaging and theranostics studies. Moreover, the design and synthesis of these pyrene-based molecules are delivered with discussions on their future scopes.

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“…This property is indispensable in biological environments, as this range is not damaging, as opposed to the UV spectrum. Their surface has oxygen-containing functional groups that allow for easy modification and molecule integration [ 121 ]. Their inert nature and stability in biological systems provide excellent biocompatibility and low toxicity.…”

Section: Materials Considerations In Wearable Biosensorsmentioning

confidence: 99%

Advances in Medical Wearable Biosensors: Design, Fabrication and Materials Strategies in Healthcare Monitoring

et al. 2021

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In the past decade, wearable biosensors have radically changed our outlook on contemporary medical healthcare monitoring systems. These smart, multiplexed devices allow us to quantify dynamic biological signals in real time through highly sensitive, miniaturized sensing platforms, thereby decentralizing the concept of regular clinical check-ups and diagnosis towards more versatile, remote, and personalized healthcare monitoring. This paradigm shift in healthcare delivery can be attributed to the development of nanomaterials and improvements made to non-invasive biosignal detection systems alongside integrated approaches for multifaceted data acquisition and interpretation. The discovery of new biomarkers and the use of bioaffinity recognition elements like aptamers and peptide arrays combined with the use of newly developed, flexible, and conductive materials that interact with skin surfaces has led to the widespread application of biosensors in the biomedical field. This review focuses on the recent advances made in wearable technology for remote healthcare monitoring. It classifies their development and application in terms of electrochemical, mechanical, and optical modes of transduction and type of material used and discusses the shortcomings accompanying their large-scale fabrication and commercialization. A brief note on the most widely used materials and their improvements in wearable sensor development is outlined along with instructions for the future of medical wearables.

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Highly fluorescent carbon dots as novel theranostic agents for biomedical applications

Abstract: As an emerging fluorescent nanomaterial, carbon dots (CDs) exhibit many attractive physicochemical features, including excellent photoluminescence properties, good biocompatibility, low toxicity and the ability to maintain the unique properties of...

Cited by 40 publications

References 150 publications

Carbon Dots in Bioimaging, Biosensing and Therapeutics: A Comprehensive Review

Carbon Dots in Bioimaging, Biosensing and Therapeutics: A Comprehensive Review

Pyrene-Based AIE Active Materials for Bioimaging and Theranostics Applications

Advances in Medical Wearable Biosensors: Design, Fabrication and Materials Strategies in Healthcare Monitoring

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