Highly enantiodifferentiating site of human serum albumin for mediating photocyclodimerization of 2-anthracenecarboxylate elucidated by site-specific inhibition/quenching with xenon

Nishijima, Masaki; Pace, Tamara C. S.; Bohne, Cornelia; Mori, Tadashi; Inoue, Yoshihisa; Wada, Takehiko

doi:10.1016/j.jphotochem.2015.12.019

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…Inoue developed a sequential “batch feeding” process to overcome the need for a higher concentration of HSA. With this process, 3.4 turnovers of HSA could be achieved without substantial loss of enantioselectivity; 312 and 315 could be isolated in 73% ee and 82% ee, respectively, under these conditions. − …”

Section: Chiral Macromolecular Photocatalystsmentioning

confidence: 93%

Chiral Photocatalyst Structures in Asymmetric Photochemical Synthesis

et al. 2021

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Asymmetric catalysis is a major theme of research in contemporary synthetic organic chemistry. The discovery of general strategies for highly enantioselective photochemical reactions, however, has been a relatively recent development, and the variety of photoreactions that can be conducted in a stereocontrolled manner is consequently somewhat limited. Asymmetric photocatalysis is complicated by the short lifetimes and high reactivities characteristic of photogenerated reactive intermediates; the design of catalyst architectures that can provide effective enantiodifferentiating environments for these intermediates while minimizing the participation of uncontrolled racemic background processes has proven to be a key challenge for progress in this field. This review provides a summary of the chiral catalyst structures that have been studied for solution-phase asymmetric photochemistry, including chiral organic sensitizers, inorganic chromophores, and soluble macromolecules. While some of these photocatalysts are derived from privileged catalyst structures that are effective for both ground-state and photochemical transformations, others are structural designs unique to photocatalysis and offer insight into the logic required for highly effective stereocontrolled photocatalysis.

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Section: Chiral Macromolecular Photocatalystsmentioning

confidence: 93%