Highly efficient synthesis of benzopyranopyridines via ZrP₂O₇nanoparticles catalyzed multicomponent reactions of salicylaldehydes with malononitrile and thiols

SnO nanoparticles as an efficient catalyst for the one-pot synthesis of chromeno[2,3-b]pyridines and 2-amino-3,5-dicyano-6-sulfanyl pyridines

“…Heterogeneous catalysis offers several advantages over the homogeneous counterpart, such as easy recovery, simple recycling without losing their activity and enhanced stability of the catalyst which can make synthetic processes cheaper, safer and greener. [26][27][28][29][30][31][32] Therefore, the possibility of performing multicomponent reactions under mild conditions with a heterogeneous catalyst could enhance their effectiveness from economic and ecological points of view.…”

Design, Synthesis and Biological Evaluation of Novel 5H-Chromenopyridines as Potential Anti-Cancer Agents

“…Recently, Ghomi et al . demonstrated tin oxide nanoparticles, as well as zirconium nanoparticle as efficient catalysts to promote four-component cyclization of salicylaldehyde, thiols and two equivalent malonitriles, resulting in 5 H -substituted-thiochromenopyridines in a good yield [19,20]. Here, we report an efficient, as well as fast three-component cyclization reaction, which works both under normal reflux and microwave irradiation, to prepare 5 H -substituted-thiochromenopyridines, as shown in Scheme 1.…”

Recent developments in the nanomaterial-catalyzed green synthesis of structurally diverse 1,4-dihydropyridines

“…31 Zirconium pyrophosphate nanoparticles are neutral, mild, and environmentally benign catalysts, and their remarkable performance in terms of the selectivity, reactivity, and high temperature stability have encouraged scientists to explore them for the synthesis of 1,4-dihydropyridines. 32,33 A three-component mixture of ethyl acetoacetate, aldehyde, NH 4 OAc, and ZrP 2 O 7 nanoparticles was reuxed in EtOH to afford 1,4dihydropyridines (Table 1; entry 8). The detailed investigation studies revealed that the best results were obtained using 10% mmol nanoparticles.…”