Highly efficient loading of doxorubicin in Prussian Blue nanocages for combined photothermal/chemotherapy against hepatocellular carcinoma

Wu, Ming; Wang, Qingtang; Liu, Xiaolong; Liu, Jingfeng

doi:10.1039/c4ra16138f

Cited by 45 publications

(47 citation statements)

References 36 publications

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“…97 Over the past two decades, MOFs have been applied in photonics, 98 catalysis, [99][100][101] biosensors, 102,103 gas storage, [104][105][106][107] and drug delivery. [108][109][110][111] For drug delivery, the high drug-loading capacity of MOFs relies largely on three factors: 1) high surface area (3,100-5,900 m 2 /g) 108 and large, regular, accessible cages and tunnels; 2) good physicochemical stability in circulation and quick stimuli 109,113 -effectively in hexane solution. X-ray powder diffraction and N 2 -adsorption experiments showed that both MOFs retained their excellent crystalline structures, and almost all the cages and tunnels were filled and/or blocked by the drug molecules.…”

Section: Absorption/desorption-type Mofs As Carriersmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

419

268

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Drug molecules transformed into nanoparticles or endowed with nanostructures with or without the aid of carrier materials are referred to as “nanomedicines” and can overcome some inherent drawbacks of free drugs, such as poor water solubility, high drug dosage, and short drug half-life in vivo. However, most of the existing nanomedicines possess the drawback of low drug-loading (generally less than 10%) associated with more carrier materials. For intravenous administration, the extensive use of carrier materials might cause systemic toxicity and impose an extra burden of degradation, metabolism, and excretion of the materials for patients. Therefore, on the premise of guaranteeing therapeutic effect and function, reducing or avoiding the use of carrier materials is a promising alternative approach to solve these problems. Recently, high drug-loading nanomedicines, which have a drug-loading content higher than 10%, are attracting increasing interest. According to the fabrication strategies of nanomedicines, high drug-loading nanomedicines are divided into four main classes: nanomedicines with inert porous material as carrier, nanomedicines with drug as part of carrier, carrier-free nanomedicines, and nanomedicines following niche and complex strategies. To date, most of the existing high drug-loading nanomedicines belong to the first class, and few research studies have focused on other classes. In this review, we investigate the research status of high drug-loading nanomedicines and discuss the features of their fabrication strategies and optimum proposal in detail. We also point out deficiencies and developing direction of high drug-loading nanomedicines. We envision that high drug-loading nanomedicines will occupy an important position in the field of drug-delivery systems, and hope that novel perspectives will be proposed for the development of high drug-loading nanomedicines.

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Section: Absorption/desorption-type Mofs As Carriersmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

419

268

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“…Compared with other inorganic PTT agents including carbon-based nanomaterials [5][6][7][8][9] , noble metal-based nanostructures [10][11][12][13][14][15] , as well as transition-metal sulfides and oxides [16][17][18][19] , which in general are not biodegradable and thus have tremendous difficulties in terms of clinical translation, PB is already a clinically approved agent and can be obtained with low costs. Therefore, many groups including ours have explored the applications of PB-based nanoagents as PTT agent for cancer treatment in animal models [20][21][22][23][24][25][26][27][28] . Further, it has been found that doping of other paramagnetic ions, such as Gd 3+ and Mn 2+ into PB could enhance its T1 contrasting ability in magnetic resonance (MR) imaging [29][30][31][32][33][34] For in vitro cell toxicity assay, 4T1 cells were seeded in 96-well plates at a density of 10 4 Bio-RAD) to determine their relative cell viability.…”

Section: Introductionmentioning

confidence: 99%

Mn²⁺-Doped Prussian Blue Nanocubes for Bimodal Imaging and Photothermal Therapy with Enhanced Performance

Zhu

Sun

et al. 2015

ACS Appl. Mater. Interfaces

124

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Prussian blue (PB) as a clinically adapted agent recently has drawn much attention in cancer theranostics for potential applications in magnetic resonance (MR) imaging as well as photothermal cancer treatment. In this work, we take a closer look at the imaging and therapy performance of PB agents once they are doped with Mn2+. It is found that Mn2+-doped PB nanocubes exhibit increased longitudinal relaxivity along with enhanced optical absorption red-shifted to the near-infrared (NIR) region. Those properties make PB:Mn nanocubes with appropriate surface coatings rather attractive agents for biomedical imaging and cancer therapy, which have been successfully demonstrated in our in vivo experiments for effectively tumor ablation.

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“…24 Meanwhile, PB-based nanostructures exhibit strong optical absorbance in NIR region, high photothermal conversion efficiency and superior photothermal stability, which also make them an extraordinary photothermal agent for PTT. [25][26][27][28][29][30][31] In addition, synthesis of PBbased nanoparticles (NPs) is cost-effective based on a simple and facile reaction between FeCl3 and K4[Fe(CN)6] in acidic condition. 32 Because the cellular uptake efficiency of ultrasmall PB NPs is considerably high, it has a good potential as a nonviral vector for efficient gene delivery 29 .…”

Section: Introductionmentioning

confidence: 99%

Functional magnetic Prussian blue nanoparticles for enhanced gene transfection and photothermal ablation of tumor cells

et al. 2016

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Gene therapy has been developed as an innovative therapeutic modality in the past few decades for treatment of various fatal diseases such as cancer. However, the lack of gene carriers with reliable biosafety and loading capacity is still impeding the practical applications of gene therapy. Meanwhile, it becomes a trend to combine multiple treatment stategies with gene therapy to achieve enhanced curative effect. Herein, this study proposes design of a multifunctional nanoplatform for gene delivery and photothermal therapy enhanced by magnetic targeting using functionalized magnetic Prussian blue nanoparticles. It is demonstrated that surface modification of magnetic Prussian blue nanoparticles with chitosan and pDNA provides excellent colloidal stability and capacity for magnetic targeting of Hela cells. These nanocomposites exhibit superparamagnetism, which is a remarkable potentiality to improve their therapeutic effect under localized magnetic field. The obtained nanoagent is able to generate significant photothermal effect due to strong optical absorbance in the near infrared region. Furthermore, superior gene transfection efficiency is achieved under magnetic guidance. In vitro experiments also reveal that this nanoagent has excellent biocompatibility for safe medical applications. This study can provide critical experimental evidence and encourage further investigation of combining photothermal therapy with gene therapy for treatment of various medical conditions.

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Highly efficient loading of doxorubicin in Prussian Blue nanocages for combined photothermal/chemotherapy against hepatocellular carcinoma

Abstract: Doxorubicin-loaded Prussian Blue-based nanoparticles for combined photothermal/chemotherapy against hepatocellular carcinoma.

Cited by 45 publications

References 36 publications

High drug-loading nanomedicines: progress, current status, and prospects

High drug-loading nanomedicines: progress, current status, and prospects

Mn²⁺-Doped Prussian Blue Nanocubes for Bimodal Imaging and Photothermal Therapy with Enhanced Performance

Functional magnetic Prussian blue nanoparticles for enhanced gene transfection and photothermal ablation of tumor cells

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Highly efficient loading of doxorubicin in Prussian Blue nanocages for combined photothermal/chemotherapy against hepatocellular carcinoma

Abstract: Doxorubicin-loaded Prussian Blue-based nanoparticles for combined photothermal/chemotherapy against hepatocellular carcinoma.

Cited by 45 publications

References 36 publications

High drug-loading nanomedicines: progress, current status, and prospects

High drug-loading nanomedicines: progress, current status, and prospects

Mn2+-Doped Prussian Blue Nanocubes for Bimodal Imaging and Photothermal Therapy with Enhanced Performance

Functional magnetic Prussian blue nanoparticles for enhanced gene transfection and photothermal ablation of tumor cells

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Product

Resources

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Mn²⁺-Doped Prussian Blue Nanocubes for Bimodal Imaging and Photothermal Therapy with Enhanced Performance