Highly efficient antimicrobial agents based on sulfur-enriched, hydrophilic molybdenum disulfide nano/microparticles and coatings functionalized with palladium nanoparticles

Molybdenum oxide nanoparticles (NPs) with tunable plasmonic resonance in the near-infrared region display superior semiconducting features and photothermal properties, which are highly related to the crystalline and defective structures such as oxygen deficiencies. However, fundamental understanding on the structure-function relationship between crystalline/defective structures and photothermal properties is still unclear. To address this, herein, we have developed an "in-situ confined oxidation-reduction" strategy to regulate the defect features of molybdenum oxide NPs in the dual-mesoporous silica nanoreactor. Especially, the effects of crystalline structure/oxygen defects of molybdenum oxides on the photothermal performances were investigated by facilely tuning the amount of molybdenum resource and the reduction temperature. As a photothermal nanoagent, the optimal defective molybdenum oxide NPs encapsulated in PEGylated porous silica nanoreactor (designated as MoO 3−x @PPSNs) exhibit excellent biological stability and strong localized surface plasmon resonance effect in nearinfrared absorption range with the highest photothermal conversion efficiency up to 78.7% under 808 nm laser irradiation. More importantly, the remarkable photothermal effects of MoO 3−x @PPSNs were comprehensively demonstrated both in vitro and in vivo. Consequently, we envision that the plasmonic MoO 3−x NPs in a biocompatible porous silica nanoreactor could be used as an efficient photothermal therapy agent for photothermal ablation of tumors.

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“…As shown in Fig. S9, MoO 3−x @PPSNs possess a low contact angle of 23.59°± 0.25°, suggesting its highly hydrophilic feature [29].…”

Section: Preparation and Characterization Of Moo 3−x @Ppsnsmentioning

confidence: 93%

Confined structure regulations of molybdenum oxides for efficient tumor photothermal therapy

et al. 2021

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“…This process is frequently used for carbon-based materials, such as carbon fibres, cloth, nanotubes etc., the modification was the formation of the oxygen-containing groups on the surface of carbon, enabling the greater hydrophilicity and improving wetting properties of the material [ 43 ]. Moreover, surfaces with enhanced wetting properties are considered to be more suitable for biomolecules, enzymes or even microorganisms’ immobilization [ 44 , 45 ]. After draining of the acidic mixture, the modified CF electrodes were washed with dozens of DI water until a neutral pH was reached for the washing solution.…”

Section: Methodsmentioning

confidence: 99%

Microbial Fuel Cell Based on Nitrogen-Fixing Rhizobium anhuiense Bacteria

et al. 2022

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In this study, the nitrogen-fixing, Gram-negative soil bacteria Rhizobium anhuiense was successfully utilized as the main biocatalyst in a bacteria-based microbial fuel cell (MFC) device. This research investigates the double-chambered, H-type R. anhuiense-based MFC that was operated in modified Norris medium (pH = 7) under ambient conditions using potassium ferricyanide as an electron acceptor in the cathodic compartment. The designed MFC exhibited an open-circuit voltage (OCV) of 635 mV and a power output of 1.07 mW m−2 with its maximum power registered at 245 mV. These values were further enhanced by re-feeding the anode bath with 25 mM glucose, which has been utilized herein as the main carbon source. This substrate addition led to better performance of the constructed MFC with a power output of 2.59 mW m−2 estimated at an operating voltage of 281 mV. The R. anhuiense-based MFC was further developed by improving the charge transfer through the bacterial cell membrane by applying 2-methyl-1,4-naphthoquinone (menadione, MD) as a soluble redox mediator. The MD-mediated MFC device showed better performance, resulting in a slightly higher OCV value of 683 mV and an almost five-fold increase in power density to 4.93 mW cm−2. The influence of different concentrations of MD on the viability of R. anhuiense bacteria was investigated by estimating the optical density at 600 nm (OD600) and comparing the obtained results with the control aliquot. The results show that lower concentrations of MD, ranging from 1 to 10 μM, can be successfully used in an anode compartment in which R. anhuiense bacteria cells remain viable and act as a main biocatalyst for MFC applications.

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“…Metallic nanoparticles (NPs) possess many unique features [ 12 ]. Studies over the past decades have provided important information on the use of silver NPs [ 13 ], zinc oxide NPs [ 14 ], copper NPs [ 15 ], composite Cu2ZnSnS4 monograins [ 16 ], composite Pd/MoS2/Ti-based coatings [ 17 ] for the killing of pathogenic microbes. Silver nanoparticles show both antibacterial and anti-biofilm activities [ 18 ], unlike antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Two Different Types of Silver Nanoparticles against Wide Range of Pathogenic Bacteria

Holubnycha,

Husak,

Korniienko

et al. 2024

Nanomaterials

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The emergence of antibiotic-resistant bacteria, particularly the most hazardous pathogens, namely Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. (ESKAPE)-pathogens pose a significant threat to global health. Current antimicrobial therapies, including those targeting biofilms, have shown limited effectiveness against these superbugs. Nanoparticles, specifically silver nanoparticles (AgNPs), have emerged as a promising alternative for combating bacterial infections. In this study, two types of AgNPs with different physic-chemical properties were evaluated for their antimicrobial and antibiofilm activities against clinical ESKAPE strains. Two types of silver nanoparticles were assessed: spherical silver nanoparticles (AgNPs-1) and cubic-shaped silver nanoparticles (AgNPs-2). AgNPs-2, characterized by a cubic shape and higher surface-area-to-volume ratio, exhibited superior antimicrobial activity compared to spherical AgNPs-1. Both types of AgNPs demonstrated the ability to inhibit biofilm formation and disrupt established biofilms, leading to membrane damage and reduced viability of the bacteria. These findings highlight the potential of AgNPs as effective antibacterial agents against ESKAPE pathogens, emphasizing the importance of nanoparticle characteristics in determining their antimicrobial properties. Further research is warranted to explore the underlying mechanisms and optimize nanoparticle-based therapies for the management of infections caused by antibiotic-resistant bacteria.

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Highly efficient antimicrobial agents based on sulfur-enriched, hydrophilic molybdenum disulfide nano/microparticles and coatings functionalized with palladium nanoparticles

Cited by 16 publications

References 58 publications

Confined structure regulations of molybdenum oxides for efficient tumor photothermal therapy

Confined structure regulations of molybdenum oxides for efficient tumor photothermal therapy

Microbial Fuel Cell Based on Nitrogen-Fixing Rhizobium anhuiense Bacteria

Antimicrobial Activity of Two Different Types of Silver Nanoparticles against Wide Range of Pathogenic Bacteria

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