Highly efficient and selective absorption of H2S in phenolic ionic liquids: A cooperative result of anionic strong basicity and cationic hydrogen-bond donation

Huang, Kuan; Zhang, Xiaomin; Zhou, Linsen; Tao, Duan‐Jian; Fan, Jie

doi:10.1016/j.ces.2017.07.048

Cited by 117 publications

(69 citation statements)

References 53 publications

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“…As phenol is known to capture H 2 S (Huang, Zhang, Zhou, Tao, & Fan, 2017), we tested if AP72 affects calcification at lower concentrations in phenol red-free medium, compared to calcification medium with phenol red. Without phenol red, AP72 significantly inhibited calcification of VIC at concentration of 2.5 nmol·L −1 to 5 μmol·L −1 ( Figure S1B).…”

Section: H2s Prevents Calcification Of Vicmentioning

confidence: 99%

Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease

Sikura

Potor

Szerafin

et al. 2019

British J Pharmacology

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Background and Purpose Calcification of heart valves is a frequent pathological finding in chronic kidney disease and in elderly patients. Hydrogen sulfide (H2S) may exert anti‐calcific actions. Here we investigated H2S as an inhibitor of valvular calcification and to identify its targets in the pathogenesis. Experimental Approach Effects of H2S on osteoblastic transdifferentiation of valvular interstitial cells (VIC) isolated from samples of human aortic valves were studied using immunohistochemistry and western blots. We also assessed H2S on valvular calcification in apolipoprotein E‐deficient (ApoE−/−) mice. Key Results In human VIC, H2S from donor compounds (NaSH, Na2S, GYY4137, AP67, and AP72) inhibited mineralization/osteoblastic transdifferentiation, dose‐dependently in response to phosphate. Accumulation of calcium in the extracellular matrix and expression of osteocalcin and alkaline phosphatase was also inhibited. RUNX2 was not translocated to the nucleus and phosphate uptake was decreased. Pyrophosphate generation was increased via up‐regulating ENPP2 and ANK1. Lowering endogenous production of H2S by concomitant silencing of cystathionine γ‐lyase (CSE) and cystathionine β‐synthase (CBS) favoured VIC calcification. analysis of human specimens revealed higher Expression of CSE in aorta stenosis valves with calcification (AS) was higher than in valves of aortic insufficiency (AI). In contrast, tissue H2S generation was lower in AS valves compared to AI valves. Valvular calcification in ApoE−/− mice on a high‐fat diet was inhibited by H2S. Conclusions and Implications The endogenous CSE‐CBS/H2S system exerts anti‐calcification effects in heart valves providing a novel therapeutic approach to prevent hardening of valves. Linked Articles This article is part of a themed section on Hydrogen Sulfide in Biology & Medicine. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.4/issuetoc

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Section: H2s Prevents Calcification Of Vicmentioning

confidence: 99%

Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease

Sikura

Potor

Szerafin

et al. 2019

British J Pharmacology

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“…As for the unit of mol/kg, the solubility of H 2 S is as highs as 6.2 mol H 2 S/kg IL, being dozens of times higher than those in normal ILs and VOCs 26–34 . Moreover, it is also significantly higher than functionalized ILs reported in literatures . The selectivities of H 2 S/CO 2 in azole‐based PILs range from 4.6 to 7.5 for S 1/1 and from 3.0 to 4.7 for S 0.1/1 , which are comparable or superior to other ILs.…”

Section: Resultsmentioning

confidence: 73%

“…The densities of these four PILs are located in 1.05–1.15 g/cm 3 at the temperature range from 298.2 to 343.2 K. [DBNH]‐based PILs show higher values than those of [DBUH]‐based PILs. [DBNH][1,2,4‐triaz] shows the lowest viscosity values of 42.6 cP at 313.2 K, significantly lower than those of other functionalized ILs toward H 2 S absorption . [DBUH][1,2,3‐triaz] shows the highest viscosity values of 666.6 cP at 313.2 K. The viscosity of [DBNH][1,2,3‐triaz] was as low as 73.5 cP at 313.2 K in spite of its high melting point.…”

Section: Resultsmentioning

confidence: 99%

“…The solubility of CO 2 is significantly lower than that of H 2 S, implying good H 2 S/CO 2 absorption selectivity in these PILs. Therefore, the low CO 2 solubility should be attributed to the donation of hydrogen bonds (NH……N) in azole‐based PILs . There is no redundant lone pair electrons to donate for CO 2 .…”

Section: Resultsmentioning

confidence: 99%

“…However, cost‐intensive and large molecular weight (unfavorable for capacity in the unit of mol/kg) made researchers to reconsider them in real application. Huang et al reported four phenolic ILs for the selectivity absorption of H 2 S from CO 2 19 . As is well known, phenolic‐based chemical substances are poisonous and hardly used for practical application in industry.…”

Section: Introductionmentioning

confidence: 99%

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Highly selective absorption separation of H₂S and CO₂ from CH₄ by novel azole‐based protic ionic liquids

et al. 2020

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Recently, the selective removal of H 2 S and CO 2 has been highly desired in natural gas sweetening. Herein, four novel azole-based protic ionic liquids (PILs) were designed and prepared through one-step neutralization reaction. The solubility of H 2 S (0-1.0 bar), CO 2 (0-1.0 bar), and CH 4 (0-5.0 bar) was systematically measured at temperatures from 298.2 to 333.2 K. NMR and theoretical calculation were used to investigate the reaction mechanism between these PILs and H 2 S. Reaction equilibrium thermodynamic model (RETM) was screened to correlate the H 2 S solubility. Impressively,1,3,0] non-5-ene 1,2,4-1H-imidazolide ([DBNH][1,-2,4-triaz]) shows the highest H 2 S solubility (1.4 mol/mol or 7.3 mol/kg at 298.2 K and 1.0 bar) and superior H 2 S/CH 4 (831) and CO 2 /CH 4 (199) selectivities compared with literature results. Considering the excellent absorption capacity of H 2 S, high

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Chelation‐activated multiple‐site reversible chemical absorption of ammonia in ionic liquids

Cai

Zhang

et al. 2022

AIChE Journal

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Developing new and facile strategies for multiple-site reversible chemical absorption of pollutant gases is of wide interests in chemical engineering research. Herein, a series of lithium (Li)-triethylene glycol (TEG)-chelated ionic liquids (ILs) with crownether-like cation and different anions were designed. The Li-TEG-chelated ILs were prepared in quantitative yields by simply mixing equimolar TEG and Li salts. It is found that the chelation of TEG with Li + activates the hydroxyl sites in TEG for strong interaction with ammonia (NH 3 ). Thus, the hydroxyl sites chelated with Li + , as well as the chelation-unsaturated Li + , provide the multiple sites for chemical absorption of NH 3 in Li-TEG-chelated ILs. Moreover, the absorption of NH 3 in Li-TEGchelated ILs is totally reversible, with the NH 3 solubilities remaining unchanged after eight times of recycling. The results obtained herein can provide useful guidance for the construction of gas absorbents with high capacity and excellent reversibility.

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Highly efficient and selective absorption of H2S in phenolic ionic liquids: A cooperative result of anionic strong basicity and cationic hydrogen-bond donation

Cited by 117 publications

References 53 publications

Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease

Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease

Highly selective absorption separation of H₂S and CO₂ from CH₄ by novel azole‐based protic ionic liquids

Chelation‐activated multiple‐site reversible chemical absorption of ammonia in ionic liquids

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Highly efficient and selective absorption of H2S in phenolic ionic liquids: A cooperative result of anionic strong basicity and cationic hydrogen-bond donation

Cited by 117 publications

References 53 publications

Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease

Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease

Highly selective absorption separation of H2S and CO2 from CH4 by novel azole‐based protic ionic liquids

Chelation‐activated multiple‐site reversible chemical absorption of ammonia in ionic liquids

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Product

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Highly selective absorption separation of H₂S and CO₂ from CH₄ by novel azole‐based protic ionic liquids