Highly effective prophylaxis with ertapenem for transrectal ultrasound-guided prostate biopsy: effects on overall antibiotic use and inpatient hospital exposure

Bloomfield, Maxim G.; Wilson, Aidan D.; Studd, Rodney C.; Blackmore, Timothy

doi:10.1016/j.jhin.2020.08.020

Cited by 7 publications

(4 citation statements)

References 22 publications

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“…A potentially controversial approach to AMS, as it involves using a carbapenem for prophylaxis, is reported in this issue by Bloomfield et al Using a single intramuscular dose of ertapenem as prophylaxis for transrectal prostate biopsy, the average total antibiotic use per biopsy was decreased, in part due to the reduced incidence of infections [20]. Recent concerns regarding adverse drug reactions with fluoroquinolones [21], as well as the known association between ciprofloxacin prophylaxis and development of resistance [22], increases the attractiveness of this approach, although the authors acknowledge that it may not be suitable for all settings e particularly those in which carbapenemase producing Enterobacterales (CPE) are already endemic.…”

mentioning

confidence: 99%

Antimicrobial stewardship: a COVID casualty?

Lynch

Mahida

Gray

2020

Journal of Hospital Infection

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mentioning

confidence: 99%

Antimicrobial stewardship: a COVID casualty?

Lynch

Mahida

Gray

2020

Journal of Hospital Infection

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“…Ciprofloxacin as an antimicrobial agent has more potential in the development of resistance than ertapenem. Where CPE is not usually seen, based on the local epidemiologic information and individual evaluation, single-dose ertapenem use would decrease post TRUSBx complications [21]. In our study, the rate of resistance to antibiotics used for prophylaxis before the procedure and ESBL bacteria rate were found to be high.…”

Section: Discussionmentioning

confidence: 54%

“…In a study, the use of single-dose ertapenem as a prophylactic agent significantly reduced the incidence of infection, rate of bacteremia, antibiotic consumption, and hospitalization length due to post TRUSBx infections [16]. Recent papers showed prophylactic use of ertapenem has not showed antibiotic resistance problems [16,20,21]; use of ertapenem is advised in literature and guidelines [8,17,22]. FQs are widely used in TRUSBx [3,4,23].…”

Section: Discussionmentioning

confidence: 99%

Should we review our prophylaxis approach for increased antibiotic resistance in transrectal prostate biopsy?

Altunsoy,

Coşer,

Kemirtlek

et al. 2024

J Infect Dev Ctries

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Introduction: This study aims to show the bacteriologic picture of acute prostatitis and bacteremia caused by infective agent after transrectal ultrasound-guided prostate biopsy (TRUSBx) and to determine the resistance rates of the infections in patients undergoing transrectal biopsy and to guide prophylaxis approach before biopsy. Methodology: The retrospective data of 935 patients who underwent TRUSBx between January 2010 to January 2019 were reviewed. Pre-biopsy urine cultures and antimicrobial susceptibility were obtained. Subsequently, patients admitted to the hospital with any complaint after biopsy were examined for severe infection complications. Results: Of the 430 (61.7%) patients who underwent urine culture before the procedure, 45 (10.5%) had growth; 30 (66.7%) of the growing microorganisms were Escherichia coli. Twenty (44.4%) of all Gram-negative agents in pre-biopsy urine culture were susceptible to quinolone. Post TRUSBx bacteremia was present in 18.2%, urinary system infection in 83.6%, and hospitalization in 61.8% of 55 patients who were admitted to the hospital. In the isolated gram-negative microorganisms, fluoroquinolones resistance in urinary system infections was seen in 40% and bacteremia was seen in 70% of the cases. ESBL-producing Gram-negative bacteria were determined in 40% of infections in blood and 38.5% of urinary system infections in the post biopsy period in the current study. Conclusions: These high antibiotic resistance rates suggest that we better review our pre-procedure prophylaxis approaches.

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“…Whereas co-amoxiclav has been shown to be less effective (175,176). Single doses of pre-biopsy carbapenem antibiotics have also been used with good effect and some evidence suggests its use may not select for carbapenem resistant organism (177)(178)(179)(180).…”

Section: Antibiotic Prophylaxis In Transrectal Biopsymentioning

confidence: 99%

Prostate Cancer Diagnosis: Biopsy Approaches

et al. 2022

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Prostate cancer is a common and increasing malignancy in men. Tissue is generally obtained using prostate biopsy for diagnosis and risk stratification. There are many prostate biopsy techniques. Historically, the transrectal approach has been the most adopted. In many centers, however, there has a been a shift towards transperineal Note to the Reader: This chapter is part of the book Urologic Cancers (ISBN: 978-0-6453320-5-6), scheduled for publication in July 2022. The book is being published by Exon Publications,

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Highly effective prophylaxis with ertapenem for transrectal ultrasound-guided prostate biopsy: effects on overall antibiotic use and inpatient hospital exposure

Cited by 7 publications

References 22 publications

Antimicrobial stewardship: a COVID casualty?

Antimicrobial stewardship: a COVID casualty?

Should we review our prophylaxis approach for increased antibiotic resistance in transrectal prostate biopsy?

Prostate Cancer Diagnosis: Biopsy Approaches

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