Highly drug-resistant Salmonella enterica serotype Kentucky ST198-X1: a microbiological study

Hello, Simon Le; Harrois, Dorothée; Bouchrif, Brahim; Sontag, Lucile; Elhani, Dalèle; Guibert, Véronique; Zerouali, Khalid; Weill, François‐Xavier

doi:10.1016/s1473-3099(13)70124-5

Cited by 159 publications

(183 citation statements)

References 31 publications

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“…Our results may partially explain the low frequency of VIM-2-producing salmonellae; however, recent reports of Salmonella carrying bla NDM (9,10,11) suggest that the latter might impose a lower biological cost on its host. Further studies are required in order to confirm or rule out such a hypothesis.…”

Section: Discussionmentioning

confidence: 56%

“…Furthermore, only a few reports concerning the occurrence of MBL in clinical isolates of this genus have been published; although epidemiologically unrelated, such isolates carried all bla NDM-1 (9,10,11), and recently, VIM-2. Consequently, the extremely low frequency of class B ␤-lactamase-producing salmonellae, together with the data presented in this work, support the hypothesis that the expression of such enzymes in this particular microorganism might be accompanied by an important fitness reduction.…”

Section: Discussionmentioning

confidence: 99%

“…Most of the clinical isolates of ␤-lactamase-producing Salmonella synthesize class A ␤-lactamases (4), and the occurrence of isolates carrying plasmidic class C ␤-lactamases has also been reported worldwide (5,6). Regarding class D ␤-lactamases, only a few variants have been reported in Salmonella serotypes (e.g., OXA-1, -2, -53, -129, and -48) (7,8,9). In addition, the occurrence of metallo-␤-lactamase (MBL)-producing salmonellae is an infrequent event.…”

mentioning

confidence: 99%

“…In recent years, a few clinical cases have been reported, all of them corresponding to NDM-producing Salmonella (10,11,12). Interestingly, VIM alleles were not reported in Salmonella isolates until 2013 (9,13).…”

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confidence: 99%

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Synthesis of Metallo-β-Lactamase VIM-2 Is Associated with a Fitness Reduction in Salmonella enterica Serovar Typhimurium

Cordeiro

Chabalgoity

Yim

et al. 2014

Antimicrob Agents Chemother

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Antibiotic resistance, especially due to ␤-lactamases, has become one of the main obstacles in the correct treatment of Salmonella infections; furthermore, antibiotic resistance determines a gain of function that may encompass a biological cost, or fitness reduction, to the resistant bacteria. The aim of this work was to determine in vitro if the production of the class B ␤-lactamase VIM-2 determined a fitness cost for Salmonella enterica serovar Typhimurium. To that end the gene bla VIM-2 was cloned into the virulent strain S. Typhimurium SL1344, using both the tightly regulated pBAD22 vector and the natural plasmid pST12, for inducible and constitutive expression, respectively. Fitness studies were performed by means of motility, growth rate, invasiveness in epithelial cells, and plasmid stability. The expression of bla VIM-2 was accompanied by alterations in micro-and macroscopic morphology and reduced growth rate and motility, as well as diminished invasiveness in epithelial cells. These results suggest that VIM-2 production entails a substantial fitness cost for S. Typhimurium, which in turn may account for the extremely low number of reports of metallo-␤-lactamase-producing Salmonella spp.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Synthesis of Metallo-β-Lactamase VIM-2 Is Associated with a Fitness Reduction in Salmonella enterica Serovar Typhimurium

Cordeiro

Chabalgoity

Yim

et al. 2014

Antimicrob Agents Chemother

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“…The international trade has facilitated the spread of those strains to the domestic poultry in the region of Mediterranean basin (Le Hello et al, 2013).…”

Section: The Prevalence Of Salmonella Serovars In Poultry Flocksmentioning

confidence: 99%

Salmonella spp. in poultry: a constant challenge and new insights

Velhner

Milanov

Kozoderović

2018

J Hellenic Vet Med Soc

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ABSTRACT. The knowledge about virulence mechanisms, resistance to antimicrobial agents and the biofilm formation ability of Salmonella spp. in poultry industry has been expanded over the years. However, in spite of the research efforts and significant investments to improve management systems in poultry industry, it has become evident that none of the methods applied in all stages of food production chain are 100% effective in eliminating Salmonella spp. Different serovars are manifesting different mechanisms of invasiveness which depend on their ability to invade lower zones of the lamina propria, their ability to gain accesses to parenchymatous organs and survive in macrophages. The ubiquitous nature of Salmonella spp. due to their adaptation to animal and plant hosts, as well as their survival in hostile environments and their enhanced capacity to produce biofilms, contribute to a long lasting contamination of the environment, feed and animals. The emergency and spread of antimicrobial resistances in Salmonella spp. raise additional concerns.

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Strategies for Circumventing Bacterial Resistance Mechanisms

Fisher

Johnson

Mobashery

2014

Handbook of Antimicrobial Resistance

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The future practices for the control of bacterial infections are uncertain. The intransigent infection is no longer found just among the immune compromised but is now found both in and out the boundaries of the hospital. Preserving the efficacy of the antibacterials we have, in order to secure the time needed to discover and develop new antibacterials, will require abrupt change: in the way antibacterials are dispensed and disposed, in the criteria used to measure clinical safety and efficacy, in the financial incentives for antibacterial development, and in the understanding of the molecular mechanisms governing the relationship between the antibacterial and the bacterium. This review examines this relationship from the particular perspective of the eventual need to circumvent resistance mechanisms in order to reclaim the lifesaving value of the antibacterial chemical.

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Highly drug-resistant Salmonella enterica serotype Kentucky ST198-X1: a microbiological study

Abstract: Institut Pasteur, Institut de Veille Sanitaire, Fondation pour la Recherche Médicale, French Government Investissement d'Avenir programme.

Cited by 159 publications

References 31 publications

Synthesis of Metallo-β-Lactamase VIM-2 Is Associated with a Fitness Reduction in Salmonella enterica Serovar Typhimurium

Synthesis of Metallo-β-Lactamase VIM-2 Is Associated with a Fitness Reduction in Salmonella enterica Serovar Typhimurium

Salmonella spp. in poultry: a constant challenge and new insights

Strategies for Circumventing Bacterial Resistance Mechanisms

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