Highly aggressive plasmablastic neoplasms in patients with rheumatoid arthritis treated with methotrexate

Combination therapy of ginsenoside compound K and methotrexate was efficient in elimination of anaemia and reduction of disease activity in adjuvant-induced arthritis rats

“… 2019 ; Tabata et al. 2019 ). Hepatic damage and gastrointestinal problems caused by MTX alter the available iron stores, and then lead to an anaemic condition.…”

“…Drugs used to treat RA in clinic include disease-modifying anti-rheumatic drugs (DMARDs), steroidal anti-inflammatory drugs, non-steroidal anti-inflammatory drugs (NSAIDs), biological agents and natural drugs (Laev and Salakhutdinov 2015). As a classical DMARD drug, low-dose MTX reduces or prevents joint damage in RA patients, but it works slowly, and long-term use of MTX can cause adverse reactions, which mainly including hepatotoxicity and hematological problems (Kim et al 2018;Lin et al 2019;Satou et al 2019;Tabata et al 2019). Hepatic damage and gastrointestinal problems caused by MTX alter the available iron stores, and then lead to an anaemic condition.…”

Emerging drug design strategies in anti-influenza drug discovery

“…In recent years, drug repurposing as a new drug development strategy has received more and more attention, and a large number of new indications drugs have been born. For example, celecoxib was initially used to treat rheumatoid arthritis and is now also used to treat colon and breast cancer 114 ; Methotrexate, which has been used to treat cancer, is also now being used to treat rheumatoid arthritis 115 ; Lidocaine was initially used for local anesthesia and later also for the treatment of arrhythmia 116 .…”