Highly active PdPt bimetallic nanoparticles synthesized by one-step bioreduction method: Characterizations, anticancer, antibacterial activities and evaluation of their catalytic effect for hydrogen generation

Aygün, Ayşenur; Gülbağça, Fulya; Altuner, Elif Esra; Bekmezci, Muhammed; Gür, Tuğba; Karimi‐Maleh, Hassan; Karimi, Fatemeh; Vasseghian, Yasser; Şen, Fatih

doi:10.1016/j.ijhydene.2021.12.144

Cited by 53 publications

(15 citation statements)

References 82 publications

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“…Moreover, biogenic NPs show great antiproliferative activities against cancers, such as breast, cervical, brain, leukemia, colon, etc., at experimental levels [ 32 ]. On the other hand, plant-mediated NPs have anti-inflammatory [ 33 ], antidiabetic [ 34 ], antiparasitic [ 35 ], antioxidant [ 36 ], and catalytic activities [ 37 ]. General NPs enhance apoptotic pathways inside malignant cells via crosstalk between several events, including enhancing ROS formation causing oxidative stress, impacting protein expression, DNA damage, immunological interventions, inhibition of transcription, site-specific cytotoxicity, and others [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

One-Step Phytofabrication Method of Silver and Gold Nanoparticles Using Haloxylon salicornicum for Anticancer, Antimicrobial, and Antioxidant Activities

et al. 2023

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Among various routes of metallic nanoparticle (NPs) fabrication, phytosynthesis has significant advantages over other conventional approaches. Plant-mediated synthesis of NPs is a fast, one-step, ecobenign, and inexpensive method with high scalability. Herein, silver (Ag) and gold (Au)-NPs were extracellularly synthesized using aqueous Haloxylon salicornicum (H@Ag-, H@Au-NPs) leaf extracts. GC-MS was performed to analyze the chemical compositions of H. salicornicum extract. H@Ag- and H@Au-NPs were characterized via UV-Vis spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, transmission and scanning electron microscopy, and Zetasizer. H@Ag- and H@Au-NPs have surface plasmon resonance at 435.5 and 530.3 nm, respectively. FTIR and GC-MS data suggest that secondary plant metabolites and hydrocarbons might be responsible for the reduction and stabilization of NPs. XRD demonstrated that both NPs have a crystalline nature. H@Ag-NPs have a uniform spherical shape, whereas H@Au-NPs are spherical with few oval and triangular shapes, and their average nanosizes were 19.1 ± 0.8 and 8.1 ± 0.3 nm, respectively. Hydrodynamic diameters of H@Ag-NPs and H@Au-NPs were 184.7 nm, 56.4, and 295.4 nm, and their potential charges were −24.0 and −24.4 mV, respectively. The inhibitory activity of 500 µg/mL H@Ag- and H@Au-NPs was tested against Sw480, Sw620, HCT-116, and Caco-2 colon cancer cell lines and two normal cell lines, including HFs and Vero. H@Ag-NPs revealed potent anticancer activity against all cancer cells at low concentrations. Sw480 was the most sensitive cell to H@Ag-NPs, whereas Sw620 was the least permeable one. These findings suggested that the antiproliferative activity of H@Ag-NPs is cell-response-dependent and may be influenced by a variety of factors, including the cellular metabolic state, which influences cellular charge and interactions with charged NPs. Although H@Au-NPs were smaller, their reactivity against cancer cells was weak, suggesting that the chemical properties, metal structure, quantity and chemistry of the functional groups on the NP surface may influence their reactivity. The biocidal activity of 1 mg/mL H@Ag- and H@Au-NPs against Staphylococcus aureus, Bacillus cereus, Escherichia coli and Klebsiella pneumoniae was assessed. H@Ag-NPs showed biocidal activity against Gram-positive bacteria compared to Gram-negative bacteria, whereas H@Au-NPs showed no inhibitory activity. FRAP and DPPH assays were used to determine the scavenging activity of the plant extracts and both NPs. H@Ag-NPs (1 mg/mL) had the greatest scavenging activity compared to tested drugs. These findings suggest that H@Ag-NPs are potent anticancer, antibacterial, and antioxidant agents, while H@Au-NPs may be used as a drug vehicle for pharmaceutical applications.

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Section: Introductionmentioning

confidence: 99%

One-Step Phytofabrication Method of Silver and Gold Nanoparticles Using Haloxylon salicornicum for Anticancer, Antimicrobial, and Antioxidant Activities

et al. 2023

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“…Drug resistance to various antibiotics and chemotherapeutic agents is the major hindrance to treating microbial and viral infections as well as cancers [ [22,23]. Thus, there are several antibacterial and anticancer mechanisms for metalloid, metal oxide, and metal NPs [24,25], which are presented here based on the related unique properties of NPs.…”

Section: Introductionmentioning

confidence: 99%

The efficiency of metal, metal oxide, and metalloid nanoparticles against cancer cells and bacterial pathogens: different mechanisms of action

Alavi

Rai

Martínez

et al. 2022

Cell. Mol. Biomed. Rep.

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“…The administration of VB‐NiNPs substantially prevented the growth of tumors in mice, according to in vivo experiments. 135 Increased cell apoptosis was found to be directly linked to improved tumor growth inhibition in the animal study. VB‐NiNPs could be a revolutionary technique for carefully monitoring cancer cells in order to effective cancer treatment.…”

Section: Applications Of Metal‐based Nms In Different Types Of Cancermentioning

confidence: 95%

Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy

Kumar

Shukla

Sharma

et al. 2023

MedComm

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Cancer is a disease associated with complex pathology and one of the most prevalent and leading reasons for mortality in the world. Current chemotherapy has challenges with cytotoxicity, selectivity, multidrug resistance, and the formation of stemlike cells. Nanomaterials (NMs) have unique properties that make them useful for various diagnostic and therapeutic purposes in cancer research. NMs can be engineered to target cancer cells for early detection and can deliver drugs directly to cancer cells, reducing side effects and improving treatment efficacy. Several of NMs can also be used for photothermal therapy to destroy cancer cells or enhance immune response to cancer by delivering immune‐stimulating molecules to immune cells or modulating the tumor microenvironment. NMs are being modified to overcome issues, such as toxicity, lack of selectivity, increase drug capacity, and bioavailability, for a wide spectrum of cancer therapies. To improve targeted drug delivery using nano‐carriers, noteworthy research is required. Several metal‐based NMs have been studied with the expectation of finding a cure for cancer treatment. In this review, the current development and the potential of plant and metal‐based NMs with their effects on size and shape have been discussed along with their more effective usage in cancer diagnosis and treatment.

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Highly active PdPt bimetallic nanoparticles synthesized by one-step bioreduction method: Characterizations, anticancer, antibacterial activities and evaluation of their catalytic effect for hydrogen generation

Cited by 53 publications

References 82 publications

One-Step Phytofabrication Method of Silver and Gold Nanoparticles Using Haloxylon salicornicum for Anticancer, Antimicrobial, and Antioxidant Activities

One-Step Phytofabrication Method of Silver and Gold Nanoparticles Using Haloxylon salicornicum for Anticancer, Antimicrobial, and Antioxidant Activities

The efficiency of metal, metal oxide, and metalloid nanoparticles against cancer cells and bacterial pathogens: different mechanisms of action

Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy

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