Abstract:The development of wound dressing materials with appropriate specifications is still a challenge to overcome the current limitations of conventional medical bandages. In this regard, simple and fast methods are highly recommended, such as film casting. In addition, deliverable nanoparticles that can act to accelerate wound integration, such as samarium oxide (Sm2O3) and magnesium oxide (MgO), might represent a potential design with a novel compositional combination. In the present research, the casted film of … Show more
“…FTIR spectra of the three CA films are shown in Figure S2B. The neat CA film showed characteristic peaks at 1733, 1369, 1222, 1032, and 903 cm –1 which were respectively ascribed to stretching vibrations of carbonyl functional groups (−CO), methyl bending (C–CH 3 ), alkoxyl stretching of the ester (C–O–C), the C–O functional group, and C–OH stretching . The presence of MgO NPs in the CA film was detected by absorption peaks at 547 and 3700 cm –1 , representing Mg–O–Mg stretching and isolated OH vibrations.…”
Section: Resultsmentioning
confidence: 99%
“…FTIR spectra of the three CA films are shown in Figure S2B. The neat CA film showed characteristic peaks at 1733, 1369, 1222, 1032, and 903 cm −1 which were respectively ascribed to stretching vibrations of carbonyl functional groups (−C�O), 57 The presence of MgO NPs in the CA film was detected by absorption peaks at 547 and 3700 cm −1 , representing Mg−O− Mg stretching and isolated OH vibrations. Interestingly, the appearance of chemically adsorbed OH was observed in the asprepared MgO NP-incorporated film, but not in their original form.…”
Section: Antibacterial Activity Evaluation the Antibacterial Activiti...mentioning
Magnesium oxide nanoparticles (MgO NPs) are one of the popular inorganic nanomaterials used for active food packaging applications, mainly due to their antimicrobial activity. Previous studies have utilized various strategies to enhance the activity by increasing surface oxygen vacancies of MgO. However, only a few of them showed competitive advantages over commercial ones. It is doubtful that when incorporated into biodegradable polymer films, these NPs still show superior antimicrobial activities and other beneficial properties. The present study synthesized a series of MgO NPs by a urea-based hydrothermal method and found that two of the surface defect-rich, {111} facet NPs released higher amounts of superoxide anions, exhibiting greater antibacterial effects against Escherichia coli and Staphylococcus aureus than those by commercial 27 nm MgO NPs. One using nitrogen calcination at 650 °C with better antibacterial activity was selected for incorporation into cellulose acetate (CA), and we found that the as-prepared 8% MgO NP-incorporated CA exhibited better antibacterial activity against S. aureus than the commercial one, while they had similar activities against E. coli. The incorporation of as-prepared MgO NPs into CA increased the tensile strength by 27% and the water vapor transmission rate (WVTR) by 29.5% compared to pristine CA, even though the tensile strength, thermal properties, and water and oxygen barrier properties, of the asprepared nanocomposite did not further improve compared to that of the commercial one. These results suggest the use of our developed MgO NPs and the CA-MgO NP nanocomposite in sustainable active packaging applications.
“…FTIR spectra of the three CA films are shown in Figure S2B. The neat CA film showed characteristic peaks at 1733, 1369, 1222, 1032, and 903 cm –1 which were respectively ascribed to stretching vibrations of carbonyl functional groups (−CO), methyl bending (C–CH 3 ), alkoxyl stretching of the ester (C–O–C), the C–O functional group, and C–OH stretching . The presence of MgO NPs in the CA film was detected by absorption peaks at 547 and 3700 cm –1 , representing Mg–O–Mg stretching and isolated OH vibrations.…”
Section: Resultsmentioning
confidence: 99%
“…FTIR spectra of the three CA films are shown in Figure S2B. The neat CA film showed characteristic peaks at 1733, 1369, 1222, 1032, and 903 cm −1 which were respectively ascribed to stretching vibrations of carbonyl functional groups (−C�O), 57 The presence of MgO NPs in the CA film was detected by absorption peaks at 547 and 3700 cm −1 , representing Mg−O− Mg stretching and isolated OH vibrations. Interestingly, the appearance of chemically adsorbed OH was observed in the asprepared MgO NP-incorporated film, but not in their original form.…”
Section: Antibacterial Activity Evaluation the Antibacterial Activiti...mentioning
Magnesium oxide nanoparticles (MgO NPs) are one of the popular inorganic nanomaterials used for active food packaging applications, mainly due to their antimicrobial activity. Previous studies have utilized various strategies to enhance the activity by increasing surface oxygen vacancies of MgO. However, only a few of them showed competitive advantages over commercial ones. It is doubtful that when incorporated into biodegradable polymer films, these NPs still show superior antimicrobial activities and other beneficial properties. The present study synthesized a series of MgO NPs by a urea-based hydrothermal method and found that two of the surface defect-rich, {111} facet NPs released higher amounts of superoxide anions, exhibiting greater antibacterial effects against Escherichia coli and Staphylococcus aureus than those by commercial 27 nm MgO NPs. One using nitrogen calcination at 650 °C with better antibacterial activity was selected for incorporation into cellulose acetate (CA), and we found that the as-prepared 8% MgO NP-incorporated CA exhibited better antibacterial activity against S. aureus than the commercial one, while they had similar activities against E. coli. The incorporation of as-prepared MgO NPs into CA increased the tensile strength by 27% and the water vapor transmission rate (WVTR) by 29.5% compared to pristine CA, even though the tensile strength, thermal properties, and water and oxygen barrier properties, of the asprepared nanocomposite did not further improve compared to that of the commercial one. These results suggest the use of our developed MgO NPs and the CA-MgO NP nanocomposite in sustainable active packaging applications.
“…[8,12] Due to their ability to replicate the extracellular matrix and create an environment conducive to proliferation and cell growth, tissue engineering frameworks have been extensively used in this field. [13,14] Chitin, a structural biopolymer found in the exoskeletons of several crustaceans and mollusks, is converted into chitosan (CS), a biodegradable polysaccharide. Chitosan is frequently regarded as biocompatible, non-antigenic, non-toxic, and bioabsorbable.…”
Section: Introductionmentioning
confidence: 99%
“…Effective polymeric dressings for treating chronic ulcers are currently in higher demand than ever [8,12] . Due to their ability to replicate the extracellular matrix and create an environment conducive to proliferation and cell growth, tissue engineering frameworks have been extensively used in this field [13,14] …”
Bacterial infections that cause chronic wounds provide a challenge to healthcare worldwide because they frequently impede healing and cause a variety of problems. In this study, loaded with tungsten oxide (WO3), Magnesium oxide (MgO), and graphene oxide (GO) on chitosan (CS) membrane, an inexpensive polymer casting method was successfully prepared for wound healing applications. All fabricated composites were characterized by X‐ray powder diffraction (XRD), Fourier transforms infrared spectroscopy (FT‐IR), and thermogravimetric analysis (TGA). A scanning electron microscope (SEM) was used to study the synthesized film samples’ morphology as well as their microstructure. The formed WO3/MgO@CS shows a great enhancement in the UV/VIS analysis with a highly intense peak at 401 nm and a narrow band gap (3.69 eV) compared to pure CS. The enhanced electron‐hole pair separation rate is responsible for the WO3/MgO/GO@CS scaffold's antibacterial activity. Additionally, human lung cells were used to determine the average cell viability of nanocomposite scaffolds and reached 121 % of WO3/MgO/GO@CS nanocomposite, and the IC50 value was found to be 1654 μg/mL. The ability of the scaffold to inhibit the bacteria has been tested against both E. coli and S. aureus. The 4th sample showed an inhibition zone of 11.5±0.5 mm and 13.5±0.5 mm, respectively. These findings demonstrate the enormous potential for WO3/MgO/GO@CS membrane as wound dressings in the clinical management of bacterially infected wounds.
“…The three active hydroxyl groups/one molecule are dynamic in introducing cellulosic proper physicochemical features [19][20][21]. Additionally, cellulose esterification produces cellulose acetate, the most prevalent natural polysaccharide in the environment, a biodegradable thermoplastic polymer [22][23][24]. CA is a semi-synthetic, biocompatible polymer with convenient hydrophilicity, degradability, and moisture retention [25].…”
A multifunctional nano-films of cellulose acetate (CA)/magnesium ortho-vanadate (MOV)/magnesium oxide/graphene oxide wound coverage was fabricated. Through fabrication, different weights of the previously mentioned ingredients were selected to receive a certain morphological appearance. The composition was confirmed by XRD, FTIR, and EDX techniques. SEM micrograph of Mg3(VO4)2/MgO/GO@CA film depicted that there was a porous surface with flattened rounded MgO grains with an average size of 0.31 µm was observed. Regarding wettability, the binary composition of Mg3(VO4)2@CA occupied the lowest contact angle of 30.15 ± 0.8o, while pure CA represents the highest one at 47.35 ± 0.4°. The cell viability % amongst the usage of 4.9 µg/mL of Mg3(VO4)2/MgO/GO@CA is 95.77 ± 3.2%, while 2.4 µg/mL showed 101.54 ± 2.9%. The higher concentration of 5000 µg/mL exhibited a viability of 19.23%. According to optical results, the refractive index jumped from 1.73 for CA to 1.81 for Mg3(VO4)2/MgO/GO@CA film. The thermogravimetric analysis showed three main stages of degradation. The initial temperature started from room temperature to 289 °C with a weight loss of 13%. On the other hand, the second stage started from the final temperature of the first stage and end at 375 °C with a weight loss of 52%. Finally, the last stage was from 375 to 472 °C with 19% weight loss. The obtained results, such as high hydrophilic behavior, high cell viability, surface roughness, and porosity due to the addition of nanoparticles to the CA membrane, all played a significant role in enhancing the biocompatibility and biological activity of the CA membrane. The enhancements in the CA membrane suggest that it can be utilized in drug delivery and wound healing applications.
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