Higher uric acid serum levels are associated with better muscle function in the oldest old: Results from the Mugello Study

Molino-Lova, Raffaele; Sofi, Francesco; Pasquini, Guido; Vannetti, Federica; Ry, Silvia Del; Vassalle, Cristina; Clerici, Mario; Sorbi, Sandro; Macchi, Claudio

doi:10.1016/j.ejim.2017.03.014

Cited by 43 publications

(32 citation statements)

References 33 publications

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“…Several studies have associated UA with muscle mass, strength or functional capacity in non-KTPs [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. The relationship between UA and muscle mass is unclear because positive associations were observed in healthy Asian individuals [ 16 ] and in hemodialysis Israeli patients [ 14 ], whereas negative associations were noted in the American population [ 13 ] and in Brazilian individuals with a moderate prevalence of Metabolic Syndrome [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…Huang et al [ 20 ] showed that muscle strength was lower in middle-aged men with high plasma UA levels. Controversially, other studies showed a positive association between muscle strength and hyperuricemia in older adults [ 17 , 18 , 19 , 21 , 22 ]. Collectively, these results show that it is still unclear whether UA is positively associated with muscle mass, strength and muscle function in non-KTPs.…”

Section: Introductionmentioning

confidence: 99%

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Serum Uric Acid Is Positively Associated with Muscle Mass and Strength, but Not with Functional Capacity, in Kidney Transplant Patients

et al. 2020

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Background: Our aim was to associate serum uric acid (UA) with muscle mass, strength and functional capacity in kidney transplant patients (KTPs). Methods: A cross-sectional study was performed on 113 KTPs. The fat-free mass and total and appendicular muscle mass were estimated by performing a bioelectrical impedance analysis. The strength was evaluated using the handgrip strength test (HGS) and the five times sit to stand test (5STS). The functional capacity was evaluated using the 4 m walk test and the short physical performance battery (SPPB). Results: Linear regression showed that the UA levels were positively associated with the muscle mass, fat-free mass, appendicular muscle mass, muscle mass index and appendicular muscle mass index. The 5STS results (seconds) were inversely associated with the UA levels, showing that individuals with higher UA were more likely to have more strength. However, UA was not associated with the HGS, 4 m walk test and SPPB results. Conclusion: UA levels were positively associated with muscle mass and strength, but not with functional capacity, in KTPs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum Uric Acid Is Positively Associated with Muscle Mass and Strength, but Not with Functional Capacity, in Kidney Transplant Patients

et al. 2020

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“…(25) also found that a higher SUA level was associated with reduced muscle mass in men with diabetes. Conversely, several studies have found that higher serum uric acid level was a protective factor of muscle function (26)(27)(28), which can counteract the excessive production of free radicals that cause muscle protein damage and eventually lead to the decline of muscle mass and strength (29).…”

Section: Discussionmentioning

confidence: 99%

Visceral Fat Area to Leg Muscle Mass Ratio Are Significantly Associated With the Risk of Hyperuricemia Among Women: A Cross-sectional Study

Wang¹,

Jiang²,

Zhang³

et al. 2020

Preprint

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Background: Previous studies have found a significant positive association between obesity, visceral fat accumulation and hyperuricemia. The purpose of the study was to explore the association between the ratio of visceral fat area to leg muscle mass(VFA-to-LMM) and hyperuricemia, and verify the role of sex differences in the association.Methods:In this cross-sectional study, a total of 3393 (43.3% for men) participants from Tianjin Union Medical Center-Health Management Center were recruited. Body composition were measured by multielectrode bioelectrical impedance analyzer. The VFA-to-LMM ratio was used as independent variable. Hyperuricemia, defined as a serum uric acid level ≥ 416 μmol/L in men and menopausal women, and ≥ 357 μmol/L in premenopausal women, was used as the dependent variable. Multiple logistic regression analysis was used to estimate the odds ratio and 95% confidence interval between VFA-to-LMM ratio and hyperuricemia.Results:The overall prevalence of hyperuricemia was 14.8%, and the prevalence of hyperuricemia in women (8.9%) was significantly lower than that in men (22.5%). After adjustment for age, smoking status (for males), menopause status (for females), drinking status, exercise frequency, blood pressure, alanine aminotransferase, fasting plasma glucose, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, creatinine, and history of diseases, a strong positive association was observed between VFA-to-LMM ratio and hyperuricemiain bothmen (4th vs. 1st quartile 1.60, 95%CI: 1.03-2.49) and women (4th vs. 1st quartile 5.22, 95%CI: 2.44-12.56).After additionally adjustment for BMI, there was still a significant positive association in women (4th vs. 1st quartile 2.57, 95%CI: 1.06-6.77), while the association disappeared in men(4th vs. 1st quartile 0.97, 95%CI: 0.55-1.70).Conclusions:The VFA-to-LMM ratio was positively associated with the risk of hyperuricemia in women after adjustments for confounders. In addition, the highest risk of hyperuricemia was observed when both VFA and LMM were at the highest quartile. However, well-controlled prospective studies are needed to further confirm the causality between VFA-to-LMM ratio and hyperuricemia.

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“… 26 Macchi et al 26 demonstrated that uric acid could have favorable effects on skeletal muscle strength in patients who are older. Molino-Lova et al 27 showed that high levels of uric acid in serum were independently associated with better muscle function and that uric acid had a favorable effect on progression of sarcopenia among individuals in the oldest age group. Thus, muscle strength and volume correlate with the level of serum creatinine and uric acid in their physiologic range.…”

Section: Discussionmentioning

confidence: 99%

Levels of serum sclerostin, FGF-23, and intact parathyroid hormone in postmenopausal women treated with calcitriol

Cheng

et al. 2018

CIA

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ObjectiveThis study aimed to determine the effect of calcitriol on serum concentrations of fibroblast growth factor-23 (FGF-23), sclerostin, intact parathyroid hormone (PTH), and handgrip strength in postmenopausal women with low bone mass.MethodsA randomized, double-blind controlled trial was carried out among 141 postmenopausal women with low bone mass. Participants were randomized into two groups: 75 participants received calcitriol 0.5 µg/day and 66 participants received a placebo for 12 weeks.ResultsAfter 12-week calcitriol treatment, significant decreases in serum intact PTH (P=0.035) and sclerostin (P=0.039), as well as significant increases in serum creatinine (P=0.027), uric acid (P=0.032), 24-hour urinary calcium (P=0.0026), and left handgrip strength (P=0.03), were observed, compared to placebo group. Level of serum sclerostin was weakly but significantly positively correlated with serum PTH (r=0.277; P=0.01) and negatively correlated with 24-hour urinary calcium (r=−0.221; P=0.04) and left handgrip strength (r=−0.338; P=0.03) after calcitriol treatment. Multiple regression analysis demonstrated that decrease in serum sclerostin was associated with decrease in PTH serum level after calcitriol treatment (OR, 7.90; 95% CI, 2.28–27.42; P=0.002). However, no significant change in FGF-23 level was observed after calcitriol treatment.ConclusionCalcitriol treatment yields a considerable decrease in serum sclerostin and significant increase of handgrip strength, and the change in serum sclerostin is regulated by serum PTH and by muscle strength.

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Higher uric acid serum levels are associated with better muscle function in the oldest old: Results from the Mugello Study

Cited by 43 publications

References 33 publications

Serum Uric Acid Is Positively Associated with Muscle Mass and Strength, but Not with Functional Capacity, in Kidney Transplant Patients

Serum Uric Acid Is Positively Associated with Muscle Mass and Strength, but Not with Functional Capacity, in Kidney Transplant Patients

Visceral Fat Area to Leg Muscle Mass Ratio Are Significantly Associated With the Risk of Hyperuricemia Among Women: A Cross-sectional Study

Levels of serum sclerostin, FGF-23, and intact parathyroid hormone in postmenopausal women treated with calcitriol

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