Abstract:Background: Our aim was to associate serum uric acid (UA) with muscle mass, strength and functional capacity in kidney transplant patients (KTPs). Methods: A cross-sectional study was performed on 113 KTPs. The fat-free mass and total and appendicular muscle mass were estimated by performing a bioelectrical impedance analysis. The strength was evaluated using the handgrip strength test (HGS) and the five times sit to stand test (5STS). The functional capacity was evaluated using the 4 m walk test and the short… Show more
“…In vivo, it may offer a neuroprotective advantage in the neurodegenerative Alzheimer’s disease [ 18 ], schizophrenia [ 19 ], Parkinson’s disease [ 20 ], multiple sclerosis [ 21 ], and serves as a depression biomarker [ 22 ]. SUA concentrations are linked to muscle strength and lean mass [ 23 ], although this was not shown in gastrointestinal tract cancer patients [ 24 ]. SUA may serve as a risk factor to predict poor thyroid function [ 25 ] or an indicator of malnutrition [ 15 ].…”
Section: Uric Acid and Goutmentioning
confidence: 99%
“…Allopurinol, a ULT medicine, has not shown any efficacy in the prevention of a first gout flare in patients with asymptomatic hyperuricemia [ 84 ]. Fundamentally, SUA level is associated with physical capacity and muscle strength in healthy subjects [ 23 , 24 ] and may only be a biological marker of non-gout conditions such as cardiovascular damage but is not a risk factor for its development [ 51 ]. Controversially, pseudo-gout, which is caused by calcium pyrophosphate deposition (CPPD), could have the same inflammatory symptoms as gout without hyperuricemia [ 85 ].…”
Section: The Causes Of Hyperuricemia Irrelevant To Goutmentioning
Hyperuricemia is a risk factor for gout. It has been well observed that a large proportion of individuals with hyperuricemia have never had a gout flare(s), while some patients with gout can have a normuricemia. This raises a puzzle of the real role of serum uric acid (SUA) in the occurrence of gout flares. As the molecule of uric acid has its dual effects in vivo with antioxidant properties as well as being an inflammatory promoter, it has been placed in a delicate position in balancing metabolisms. Gout seems to be a multifactorial metabolic disease and its pathogenesis should not rely solely on hyperuricemia or monosodium urate (MSU) crystals. This critical review aims to unfold the mechanisms of the SUA role participating in gout development. It also discusses some key elements which are prerequisites for the formation of gout in association with the current therapeutic regime. The compilation should be helpful in precisely fighting for a cure of gout clinically and pharmaceutically.
“…In vivo, it may offer a neuroprotective advantage in the neurodegenerative Alzheimer’s disease [ 18 ], schizophrenia [ 19 ], Parkinson’s disease [ 20 ], multiple sclerosis [ 21 ], and serves as a depression biomarker [ 22 ]. SUA concentrations are linked to muscle strength and lean mass [ 23 ], although this was not shown in gastrointestinal tract cancer patients [ 24 ]. SUA may serve as a risk factor to predict poor thyroid function [ 25 ] or an indicator of malnutrition [ 15 ].…”
Section: Uric Acid and Goutmentioning
confidence: 99%
“…Allopurinol, a ULT medicine, has not shown any efficacy in the prevention of a first gout flare in patients with asymptomatic hyperuricemia [ 84 ]. Fundamentally, SUA level is associated with physical capacity and muscle strength in healthy subjects [ 23 , 24 ] and may only be a biological marker of non-gout conditions such as cardiovascular damage but is not a risk factor for its development [ 51 ]. Controversially, pseudo-gout, which is caused by calcium pyrophosphate deposition (CPPD), could have the same inflammatory symptoms as gout without hyperuricemia [ 85 ].…”
Section: The Causes Of Hyperuricemia Irrelevant To Goutmentioning
Hyperuricemia is a risk factor for gout. It has been well observed that a large proportion of individuals with hyperuricemia have never had a gout flare(s), while some patients with gout can have a normuricemia. This raises a puzzle of the real role of serum uric acid (SUA) in the occurrence of gout flares. As the molecule of uric acid has its dual effects in vivo with antioxidant properties as well as being an inflammatory promoter, it has been placed in a delicate position in balancing metabolisms. Gout seems to be a multifactorial metabolic disease and its pathogenesis should not rely solely on hyperuricemia or monosodium urate (MSU) crystals. This critical review aims to unfold the mechanisms of the SUA role participating in gout development. It also discusses some key elements which are prerequisites for the formation of gout in association with the current therapeutic regime. The compilation should be helpful in precisely fighting for a cure of gout clinically and pharmaceutically.
“…In addition to these risk factors, age-related decreases in hormone concentrations could cause loss of muscle mass and strength, such as growth hormone, testosterone, thyroid hormone, vitamin D, albumin and insulin-like growth factor 4 . Another metabolic factor, uric acid (UA), was studied most recently in the relationship with skeletal muscle mass and/or strength, but the conclusions were varied and ambiguous 5,6 .…”
Section: Introductionmentioning
confidence: 99%
“…Recently, it was found that UA was positively associated with muscle mass and strength in kidney transplant patients 6 . Besides, another cross-sectional study showed that a speci c range of serum UA levels may be associated with better hand grip strength among Chinese adults aged over 45 5 .…”
Background: Sarcopenia is the decline in muscle strength and mass attributed to aging. The pathogenesis of sarcopenia may be triggered by oxidative stress and uric acid (UA) has strong antioxidant properties. The aim of this study was to investigate the relationship between UA and sarcopenia in community-dwelling adults of West China using the baseline data of West China Health and Aging Trend (WCHAT) study. Methods: 4236 adults aged 50 years or older in communities of west China were enrolled in this study. We applied AWGS 2019 criteria to define sarcopenia. Muscle mass was measured using skeletal muscle index (SMI) based on bioimpedance analysis (BIA). Handgrip strength (HGS) and gait speed (GS) were recorded, respectively. Different variables like anthropometry measures, life styles, chronic disease and blood test were collected.Results: Participants were grouped according to UA quartiles by gender. After adjusting for potential confounders, a significant association between serum UA levels and sarcopenia was shown both in men and women. And a significant association between serum UA levels and HGS in women was shown as a inverted J shape. Besides, the association between the UA quartiles and SMI was significant, irrespective of gender.Conclusions: Our results showed that a specific range of serum UA levels might be associated with sarcopenia and better HGS or SMI among Chinese adults aged over 50. Higher UA serum levels might slow down the progression of sarcopenia.
“…Uric acid was also a major focus in this issue. Floriano and coworkers used bioelectrical impedance analysis, hand grip strength tests and five repetitions of sit-to-stand tests in a cohort of 113 kidney transplant recipients and showed that uric acid (UA) levels were positively associated with muscle mass and strength, but not with functional capacity [ 11 ], while Dominguez-Zabrano et al underlined the antioxidant properties of uric acid in HD patients [ 12 ]. In another interesting study involving living kidney donors, Oba and coworkers showed that single nephron Glomerular Filtration Rate (GFR) was directly associated with protein intake but not with sodium intake, BMI or arterial pressure [ 13 ].…”
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