Higher soluble P-selectin is associated with chronic venous insufficiency: The San Diego Population Study

Bryan, Locke J.; Callas, Peter W.; Criqui, Michael H.; Cushman, Mary

doi:10.1016/j.thromres.2012.07.012

Cited by 9 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Framingham Heart Study Offspring and Omni studies revealed correlates of sP-selectin levels: male sex, age, cigarette smoking, and other modifiable cardiovascular risk factors [ 69 ]. sP-selectin is also more abundant in the blood (serum and plasma) of patients with severe chronic venous insufficiency [ 70 ]. In community-acquired pneumonia plasma sP-selectin is increased [ 71 ] and predicts the occurrence of myocardial infarction [ 72 ].…”

Section: Discussionmentioning

confidence: 99%

Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study

Nowak

Wojsyk‐Banaszak

Mądry

et al. 2017

Lung

View full text Add to dashboard Cite

PurposeAs life expectancy in cystic fibrosis (CF) increases, questions regarding its potential impact on cardiovascular health arise. Soluble vascular cell adhesion molecule 1 (sVCAM-1), P-selectin (sP-selectin) are proposed as biomarkers of cardiovascular disease. We aimed to: compare their concentrations in clinically stable CF patients and healthy subjects (HS) and verify whether they independently correlate with CF characteristics.MethodsSerum sVCAM-1 and sP-selectin levels were measured using ELISA. CF was characterized using: forced expiratory volume in 1 s, exocrine pancreatic and CF-related liver disease status, Pseudomonas aeruginosa colonization, serum high-sensitivity C-reactive protein, and body mass index (BMI). CFTR genotypes were classified as severe (classes I and II) or other.Results108 CF patients and 51 healthy subjects volunteered for the study. In the CF group BMI was lower (median [IQR]: 20.5 kg/m2 [18.4–22.2] vs. 21.6 kg/m2 [19.9–23.4], p = 0.02) and hsCRP levels were higher (3.6 mg/L [1.1–7.1] vs. 0.5 mg/dL [0.3–1.0], p < 10−10). While sVCAM-1 concentrations were greater in CF patients (1018 ng/mL [851–1279] vs. 861 ng/mL [806–979], p < 10−4), sP-selectin levels did not differ (155 ng/mL [129–188] vs. 156 ng/mL [144–177], p = 0.48). None of the multivariable regression models was valid for the prediction of sVCAM-1 and sP-selectin in CF.ConclusionsWe found higher sVCAM-1 concentrations in CF patients than in healthy subjects, which were not explained by CF characteristics. Further research is required to check whether sVCAM-1 is a marker of microangiopathy in CF.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study

Nowak

Wojsyk‐Banaszak

Mądry

et al. 2017

Lung

View full text Add to dashboard Cite

show abstract

“…In other study related to body weight found that there is an association of higher Pselectin with risk of Chronic venous insufficiency (CVI) (30) .…”

Section: Discussionmentioning

confidence: 97%

Soluble P-Selectin Level in Patients with Deep Venous Thrombosis

Saadeldin

El-Sakhawy

Shalaby

et al. 2018

Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

Background: Venous thromboembolic disease (VTE) remains a significant source of morbidity and mortality. As non-specific subjective complaints and a lack of objective clinical examination findings complicate the diagnosis of both deep venous thrombosis (DVT) and pulmonary embolism. Objective diagnostic testing is required to confirm or exclude the presence of venous thromboembolism before subjecting patients to unnecessary long-term anticoagulation. Aim of the Work: This study was aimed to measure the level of soluble P-selectin (sPsel) in Egyptian patients with DVT and asses its diagnostic value in relation to other clinical data and radiological examination. Subjects and Methods: This study was carried out on 80 individuals, attending Ain Shams University Hospitals between October 2015 and March 2016 after Ethical committee approval. They were divided into two groups.: Group I, 50 patients who were positive for DVT by duplex ultrasound. They were 41 males and 9 females. Their ages ranged 20-77 years, with a mean of 46.20 ± 11.78 years. They were 41 (82%) males and 9 (18%) females, with a male to female ratio of 4.55:1. Group II: 30 healthy subjects with no clinical signs, symptoms, or history of DVT. They were 23 (76.7%) males and 7 (23.3%) females, with a male to female ratio of 3.28:1. Results: There was a highly significant difference between patients (group I) and controls (group II) as regards P-selectin, the best cut off was70.5 ng/ml with 98% sensitivity, 100% specificity, a NPV of 96.8% and a PPV of 100%. Conclusion: Diagnostic cutoff levels of P-selectin in cases with DVT is 70.5 mg/L that can safely differentiate patients who are free from DVT from others who are positive for DVT or those who would eventually develop thrombosis regardless their primary duplex ultrasound scanning results. Recommendations: As our study recommends the use of serum P-selectin as diagnostic biomarker in DVT alone; in addition to the newly estimated cutoff levels for these biomarker, further studies on larger number of cases are needed for more evaluation of these cutoff values and to establish whether they could be used to guide anticoagulation therapy when duplex ultrasound is unavailable.

show abstract

“…However, the authors included lower number of patients classified as C2 according to CEAP system. Bryan et al revealed that a higher circulating sP-selectin is associated only with severe CVI and not with CVI overall [ 67 ]. However the correlation of sP-selectin and vWf with elastase and hsCRP, respectively, observed in the present study, suggests that they may be indicators of inflammation rather than ED.…”

Section: Discussionmentioning

confidence: 99%

Plasma concentration of selected biochemical markers of endothelial dysfunction in women with various severity of chronic venous insufficiency (CVI)—A pilot study

Budzyń

Iskra

Turkiewicz³

et al. 2018

PLoS ONE

View full text Add to dashboard Cite

BackgroundAlthough the endothelial dysfunction is considered to be implicated in the pathogenesis of chronic venous insufficiency (CVI) the endothelial status in patients with venous disorders is still not fully evaluated. Therefore the aim of the study was to measure the concentration of selected markers of endothelial dysfunction: von Willebrand factor (vWf), soluble P-selectin (sP-selectin), soluble thrombomodulin (sTM) and soluble VE-cadherin (sVE-cadherin) in CVI women who constitute the most numerous group of patients suffering from venous disease.Materials and methodsForty four women with CVI were involved in the study and divided into subgroups based on CEAP classification. Concentration of vWf, sP-selectin, sTM and sVE-cadherin were measured and compared with those obtained in 25 healthy age and sex-matched women.ResultsIt was found that the concentration of sTM increased and sVEcadherin decreased along with disease severity in CVI women. A significant rise of sTM was observed especially in CVI women, with the highest inflammation status reflected by hsCRP or elastase concentration, and in CVI women with a high oxidative stress manifested by an increased plasma MDA. A significant fall of circulating sVE-cadherin was reported in CVI women with moderate to highest intensity of inflammation and oxidative stress. There was no change in vWF and sP-selectin concentration at any stage of CVI severity.ConclusionsThe results of the present study demonstrate the presence of endothelial dysfunction in women suffering from CVI which seems to progress with the disease severity and may be associated with inflammation and enhanced oxidative stress.

show abstract

Higher soluble P-selectin is associated with chronic venous insufficiency: The San Diego Population Study

Cited by 9 publications

References 25 publications

Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study

Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study

Soluble P-Selectin Level in Patients with Deep Venous Thrombosis

Plasma concentration of selected biochemical markers of endothelial dysfunction in women with various severity of chronic venous insufficiency (CVI)—A pilot study

Contact Info

Product

Resources

About