Higher serum uric acid is associated with increased arterial stiffness in Japanese individuals

Ishizaka, Nobukazu; Ishizaka, Yuko; Toda, Etsuko; Hashimoto, Hideki; Nagai, Ryozo; Yamakado, Minoru

doi:10.1016/j.atherosclerosis.2006.04.016

Cited by 96 publications

(88 citation statements)

References 37 publications

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“…26 We also confirmed the results of another study that showed a significant independent correlation between PWV and uric acid. 27 The close relationship between baPWV and uric acid observed in the present study supports the theory that uric acid is a marker of cardiovascular events, 28 although this is controversial. 29 Carotid-femoral PWV has been accepted as a standard method to evaluate aortic stiffness, and evidence is accumulating that an increased carotid-femoral PWV measurement is associated with increased cardiovascular morbidity and mortality.…”

Section: Discussionsupporting

confidence: 85%

Factors associated with brachial-ankle pulse wave velocity in the general population

et al. 2011

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The present study investigated factors that modify or affect arterial stiffness as assessed by brachial-ankle pulse wave velocity (baPWV) in the general population. Subjects had previously participated in a physical checkup program (n ¼ 911), and baPWV and urinary albumin and sodium excretion were also measured. Urine albumin was expressed as the ratio of urine albumin to urine creatinine. Individual salt intake was assessed by estimating 24-h urinary salt excretion and expressed as the ratio of estimated salt intake to body weight. The mean blood pressure and baPWV were 127.1±15.2/77.0±9.5 mm Hg and 15.9±3.3 m s À1 , respectively. Univariate analysis demonstrated that baPWV correlated with various factors including age, blood pressure, electrocardiogram voltage (SV 1 þ RV 5 ), urine albumin and salt intake. Multivariate regression analysis revealed that electrocardiogram voltage (Po0.001), systolic blood pressure (Po0.0001), urine albumin (Po0.001) and salt intake (Po0.001), independently correlated with baPWV after adjustment for other possible factors. Similar results were obtained for participants not taking any medication. These results suggest that the baPWV value is independently associated with individual salt intake and cardiac and renal damage, and could be a useful procedure for identifying individuals with concealed risk of cardiovascular disease.

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Section: Discussionsupporting

confidence: 85%

Factors associated with brachial-ankle pulse wave velocity in the general population

et al. 2011

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“…Subclinical, low-grade inflammation and hyperuricaemia are frequently associated with several components of MS as well as with functional and structural alterations of the arterial bed. [25][26][27][28][29][30] Nevertheless, in this study, the relationship between arterial stiffness and MS was independent of hs-CRP and uric acid. As for gender influence, patients with MS were more frequently male; however, AASI levels were higher in these patients regardless of gender.…”

Section: Discussioncontrasting

confidence: 67%

Metabolic syndrome and ambulatory arterial stiffness index in non-diabetic patients with primary hypertension

et al. 2007

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Increased arterial stiffness and the presence of metabolic syndrome (MS) have been shown to predict cardiovascular events in patients with primary hypertension. We investigated the relationship between a recently proposed index of arterial stiffness derived from ambulatory blood pressure (BP) monitoring and MS in 156 untreated, non-diabetic patients with primary hypertension. Ambulatory arterial stiffness index (AASI) was defined as 1 minus the regression slope of diastolic over systolic BP readings obtained from 24-h recordings. A modified National Cholesterol Education Program definition for MS was used, with body mass index replacing waist circumference. The prevalence of MS was 23%. Patients with MS were more frequently male (0.0291) and had increased serum uric acid (P ¼ 0.0005), high-sensitivity C-reactive protein (P ¼ 0.0259), as well as total and low-density lipoprotein (LDL)-cholesterol (P ¼ 0.0374 and P ¼ 0.0350, respectively) as compared to those without MS. After adjusting for these confounders, the association between AASI and the presence of MS was statistically significant (P ¼ 0.0257). Moreover, the prevalence of increased AASI (upper tertile, that is X0.550) was greater in patients with MS (P ¼ 0.0156). After adjusting for age and 24-h mean BP, the presence of MS entailed a more than twofold greater risk for increased AASI (0.0280). MS is associated with increased AASI in non-diabetic patients with primary hypertension. These data support the role of this new index of arterial stiffness as a marker of risk and help to explain the high cardiovascular morbidity and mortality that is observed in hypertensive patients with MS.

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“…In clinical and epidemiological studies, SUA has been found to be positively related to the risk of hypertension, 1-3 atherosclerosis, 4 CVDs 5 and metabolic syndrome. 6 Although several studies have found that an elevated uric acid level was an independent risk factor for hypertension, not all epidemiological population studies support uric acid as an independent risk factor for hypertensive disease.…”

Section: Discussionmentioning

confidence: 99%

“…This study suggests that in both genders SUA level is associated with increased brachialankle pulse wave velocity, a marker of arterial stiffness, and is in part independent of other conventional risk factors for atherosclerosis and metabolic syndrome. 4 A recent study showed that higher SUA was closely linked to alterations in lipoprotein metabolism, which may represent an early sign of atherosclerosis in subjects. 17 In the stratified analyses, we also found significant interactions between uric acid status and age on hypertension.…”

Section: Discussionmentioning

confidence: 99%

“…In clinical and epidemiological studies, SUA has been found to be positively related not only to the risk of hypertension [1][2][3] but also to the risk of atherosclerosis, 4 cardiovascular diseases (CVDs) 5 and metabolic syndrome. 6 To prevent the incidence of hypertension effectively, it has become increasingly important to assign weightage to the influence of individual risk factors.…”

Section: Introductionmentioning

confidence: 99%

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Interaction between serum uric acid and triglycerides in relation to blood pressure

et al. 2010

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The aim of this study was to examine the independent relationship between serum uric acid (SUA) and blood pressure, and to assess their joint effects on obesity, fasting glucose and lipids. The study samples were from a community-based health examination survey in Xuzhou, Jiangsu province of China (2009). Blood pressure, body mass index, fasting glucose, lipids and SUA were measured. After excluding individuals with fasting glucose greater than 7 mmol l À1 , a total of 8415 subjects with biomarkers available were included in the present study. Blood pressure increased with elevated SUA levels, after adjusting for age and sex. Further adjustment for fasting glucose, lipids and alcohol consumption did not change the increasing trend. The associations between uric acid and hypertension were most evident in those with highest quintiles of high-density lipoprotein cholesterol (HDL-C). In addition, the associations were significant in both men and women, and we found significant interactions between uric acid status and age on hypertension. When the joint effects were examined, we found an additive effect of triglycerides and uric acid levels on diastolic blood pressure (DBP). There was significant association between SUA and hypertension, independent of other metabolic risk factors. HDL-C levels may modify the associations between uric acid and hypertension. The effects of triglycerides and uric acid levels on DBP were additive.

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Higher serum uric acid is associated with increased arterial stiffness in Japanese individuals

Cited by 96 publications

References 37 publications

Factors associated with brachial-ankle pulse wave velocity in the general population

Factors associated with brachial-ankle pulse wave velocity in the general population

Metabolic syndrome and ambulatory arterial stiffness index in non-diabetic patients with primary hypertension

Interaction between serum uric acid and triglycerides in relation to blood pressure

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