Interaction between serum uric acid and triglycerides in relation to blood pressure

Abstract

The aim of this study was to examine the independent relationship between serum uric acid (SUA) and blood pressure, and to assess their joint effects on obesity, fasting glucose and lipids. The study samples were from a community-based health examination survey in Xuzhou, Jiangsu province of China (2009). Blood pressure, body mass index, fasting glucose, lipids and SUA were measured. After excluding individuals with fasting glucose greater than 7 mmol l À1 , a total of 8415 subjects with biomarkers available were included in the present study. Blood pressure increased with elevated SUA levels, after adjusting for age and sex. Further adjustment for fasting glucose, lipids and alcohol consumption did not change the increasing trend. The associations between uric acid and hypertension were most evident in those with highest quintiles of high-density lipoprotein cholesterol (HDL-C). In addition, the associations were significant in both men and women, and we found significant interactions between uric acid status and age on hypertension. When the joint effects were examined, we found an additive effect of triglycerides and uric acid levels on diastolic blood pressure (DBP). There was significant association between SUA and hypertension, independent of other metabolic risk factors. HDL-C levels may modify the associations between uric acid and hypertension. The effects of triglycerides and uric acid levels on DBP were additive.

Uric acid concentration as a risk marker for blood pressure progression and incident hypertension: A Chinese cohort study

“…In addition, results of models using SUA as a continuous variable were also consistent with analyses assessing trend across quartiles. Our principal findings relating SUA to blood pressure outcomes at short-term follow-up were in agreement with previous reports [24][25][26][27][28][29][30][31][32][33]. Our data were also consistent with results of previous meta-analysis showing a 55% increased risk of hypertension in those in the highest category of uric acid compared with those in the lowest [31].…”

Serum uric acid and the risk of mortality during 23 years follow-up in the Scottish Heart Health Extended Cohort Study

“…Thus, hyperuricemia in participants with diabetes is likely more severe than in participants without diabetes. With regard HDLc, prior clinical studies have described an interaction between HDLc and uric acid with respect to hypertension [43]. Hypertension may mediate the interaction observed in our study with respect to mortality.…”

Disorders of Lipid Metabolism in Chronic Kidney Disease

“…1). Last but not the least, elevated serum ucid acid levels observed in CKD is also associated with lipid disorders [33-37]. …”