Higher serum levels of uric acid are associated with a reduced insulin clearance in non-diabetic individuals

Fiorentino, Teresa Vanessa; Sesti, Franz; Succurro, Elena; Pedace, Elisabetta; Andreozzi, Francesco; Sciacqua, Angela; Hribal, Marta Letizia; Perticone, Francesco; Sesti, Giorgio

doi:10.1007/s00592-018-1153-8

Cited by 24 publications

(19 citation statements)

References 43 publications

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“…Höieggen et al [30] studied the relationship between SUA and insulin resistance in untreated borderline hypertensive young men, and they found no relationship. Other two studies conducted by Vuorinen-markkola et al [31] and Fiorentino et al [32] reported SUA was independently associated with insulin sensitivity in non-diabetic subjects, which were accorded with our results. Fiorentino et al [32] also found high SUA levels correlated with reduced insulin clearance.…”

Section: Discussionsupporting

confidence: 93%

Association of uric acid and glucose disposal rate value in euglycemic Chinese subjects

Yuan

Liu

Dong

et al. 2020

Preprint

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Background: We aimed to examine the relationship between serum uric acid (SUA) levels and glucose disposal rate value (M value) evaluated by hyperinsulinemic euglycemic clamp technique in euglycemic Chinese subjects.Methods: There were 19 non-diabetic Chinese subjects included in this study. The participants accepted physical examination, laboratory examination and standardized questionnaire. Insulin resistance was evaluated by M value. Some other indices were also calculated by data obtained from 3-hour oral glucose tolerance test (OGTT). Subjects were divided into two groups based on the median of SUA levels.Results: The level of systolic blood pressure (SBP) (P=0.035), waist circumference (P=0.009), waist-to-hip ratio (P=0.004), Chinese visceral adiposity index (CAVI) (P=0.028), weight (P=0.01), serum creatinine (Cr) (P=0.05) and the percentage of drinking habits (P=0.03) were all significantly increased in high SUA group. The level of M value and high-density lipoprotein cholesterol (HDL-c) were significantly decreased in high SUA group (P=0.041 for M value and P=0.09 for HDL-c). There were no significant differences between those indirect insulin resistance indices and SUA. In addition, the SUA levels were inversely correlated with M value (r=-0.666, P=0.002) and HDL-c (r=-0.619, P=0.005), positively correlated with waist circumference (r=0.615, P=0.005), CVAI (r=0.630, P=0.004), SBP (r=0.521, P=0.022) and Cr (r-0.550, P=0.015) levels. Analysis of stepwise multiple regression showed the independent association between SUA and M value in both male and female euglycemic subjects.Conclusions: There is a significant correlation between SUA levels and glucose disposal rate value in euglycemic Chinese subjects, which suggested that UA played an important role on insulin resistance even in those non-diabetic subjects

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Section: Discussionsupporting

confidence: 93%

Association of uric acid and glucose disposal rate value in euglycemic Chinese subjects

Yuan

Liu

Dong

et al. 2020

Preprint

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“…Through reading a large number of literature and studies, we believe that uric acid is closely related to diabetes. Poor lipid metabolism in individuals with higher UA levels may lead to increased fasting and postprandial insulin levels, high-sensitivity C-reactive protein, hepatic insulin resistance index, and decreased glomerular filtration rate and skeletal muscle insulin sensitivity; high levels of SUA may impair liver insulin sensitivity and insulin clearance [53]. Perticone F [54] was documented when hypertensive NGT ≥ 155 mmHg, and UA is closely related to 1-h postload glucose during an oral glucose tolerance.…”

Section: Epidemiology Studiesmentioning

confidence: 99%

Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications

Xiong

Liu

2019

International Journal of Endocrinology

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With the deepening of the researches on uric acid, especially in the study of metabolic diseases, uric acid has been found to be closely related to obesity, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, and other metabolic diseases. Uric acid causes a series of pathophysiological changes through inflammation, oxidative stress, vascular endothelial injury, and so on and thus subsequently promotes the occurrence and development of diseases. This review confirmed the positive correlation between uric acid and diabetes mellitus and its chronic complications through the pathogenesis and clinical studies aspects.

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“…Interestingly, it has been shown that UA promotes oxidative stress and vascular inflammation [11], reducing nitric oxide bioavailability thus favouring endothelial dysfunction [12]. Moreover, UA may directly affect the intracellular insulin signalling pathway, consequently inducing insulin resistance (IR) [13]. All these mechanisms may, in turn, cause subclinical organ damage, and accumulating evidence indicates that higher UA concentrations are associated with arterial stiffness (AS), a marker of vascular damage, and an independent predictor of cardiovascular (CV) events.…”

Section: Introductionmentioning

confidence: 99%

Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance

et al. 2020

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Increased levels of uric acid (UA) have been shown to be correlated with many clinical conditions. Uric acid may adversely affect the insulin signalling pathway inducing insulin resistance (IR). Several studies report the association between arterial stiffness (AS), an early indicator of atherosclerosis, and UA. The purpose of the present study was to evaluate the association between UA and AS, considering the potential role of IR. We enrolled 1114 newly diagnosed, never-treated hypertensive patients. Insulin resistance was assessed by the homeostatic model assessment (HOMA) index. Arterial stiffness was evaluated as the measurement of the carotid–femoral pulse wave velocity (PWV). The study cohort was divided into subgroups, according to increasing tertiles of UA. The mean values of UA were 5.2 ± 1.6 mg/dL in the overall population. Pulse wave velocity was linearly correlated with UA (p < 0.0001), HOMA (p < 0.0001), high sensitivity C-reactive protein (p < 0.0001), systolic blood pressure (p < 0.0001) and LDL cholesterol (p = 0.005). Uric acid was the strongest predictor of PWV and was associated with the highest risk for increased AS. The interaction analysis showed that the joint effect of increased UA and HOMA was significantly higher than that expected in the absence of interaction under the additive model, indicating that the two biomarkers synergically interacted for promoting vascular damage. Our data showed that UA interacted with IR to increase AS in a large cohort of newly diagnosed, never-treated hypertensive patients.

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Higher serum levels of uric acid are associated with a reduced insulin clearance in non-diabetic individuals

Abstract: Higher serum levels of UA may affect insulin clearance by impairing hepatic insulin sensitivity.

Cited by 24 publications

References 43 publications

Association of uric acid and glucose disposal rate value in euglycemic Chinese subjects

Association of uric acid and glucose disposal rate value in euglycemic Chinese subjects

Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications

Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance

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