Higher Serum 25-Hydroxyvitamin D Concentrations Associate with a Faster Recovery of Skeletal Muscle Strength after Muscular Injury

Barker, Tyler; Henriksen, Vanessa T.; Martins, Thomas B.; Hill, Harry R.; Kjeldsberg, Carl R.; Schneider, Erik; Dixon, Brian; Weaver, Lindell K.

doi:10.3390/nu5041253

Cited by 106 publications

(92 citation statements)

References 90 publications

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“…Our results are comparable with others showing that vitamin D levels are related with neuromuscular performance capacity and aerobic endurance in young physically active individuals and athletes [202][203][204][205]. However, these findings are not universal.…”

Section: Vitamin D Levels Athletes and Exercise Performancesupporting

confidence: 88%

Vitamin D and Physical Activity

Koundourakis¹,

Margioris²

2017

A Critical Evaluation of Vitamin D - Basic Overview

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Vitamin D is synthesized in the skin following exposure to ultraviolet radiation, producing cholecalciferol, while only a small percentage of the circulating vitamin D is of exogenous origin deriving from food. Following two sequential hydroxylations, in the liver and in the kidneys, vitamin D is fully activated. Although its role in bone physiology and calcium homeostasis is well documented, there is emerging evidence that vitamin D exerts a plethora of additional effects on most tissues regulating the musculoskeletal, cardiovascular, and immune systems as well as energy homeostasis. Its deficiency/insufficiency poses a major public health problem observed in all age groups and regardless of latitude and insolation. In muscles, vitamin D deficiency is associated with a decline in neuromuscular function including muscular strength, walking speed, balance, jumping and sprinting performance, and aerobic capacity, although the evidence is still weak regarding its effects in the young and the athletes. Supplementation counteracts the negative effects of vitamin D deficiency on performance although in individuals with adequate levels of vitamin D, additional supplementation does not appear to enhance further physical capabilities. The aim of this chapter is to review our current understanding of diverse effects of vitamin D in physical performance in athletic and nonathletic populations.

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Section: Vitamin D Levels Athletes and Exercise Performancesupporting

confidence: 88%

Vitamin D and Physical Activity

Koundourakis¹,

Margioris²

2017

A Critical Evaluation of Vitamin D - Basic Overview

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“…our results are comparable with a number of other reports on a variety of sports, all showing that vitamin D levels are closely associated with muscle power, neuromuscular performance and aerobic endurance in athletes. [110][111][112] of note, Hamilton et al 113 reported that vitamin D levels were not associated with lower limb isokinetic muscle function in soccer players, although those soccer players with lower levels of vitamin D exhibited a significantly lower torque in hamstring and quadriceps muscle groups compared to those with higher vitamin D levels, a finding suggesting that lower vitamin D levels are indeed associated with inferior muscular function during exercise.…”

Section: Vitamin D Levels and Indices Of Athletic Performance In Soccmentioning

confidence: 99%

Muscular effects of vitamin D in young athletes and non-athletes and in the elderly

Koundourakis¹,

Avgoustinaki²,

Malliaraki³

et al. 2017

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“…In support of such a contention, is the finding that higher 25(OH)D concentration are associated with faster recovery from induced muscle injury. 28 Furthermore, a RCT of 28 healthy adults found 100 m day of vitamin D 3 enhanced the recovery in peak isometric force after a muscle-damaging event (P < 0.05). 29 In that study, supplemental vitamin D 3 attenuated (P < 0¢05) the immediate and delayed (2 day, 3 day and 7 day) increase in circulating biomarkers of muscle damage.…”

mentioning

confidence: 99%

Vitamin D and inflammation

Cannell¹,

Grant

Holick

2014

Dermato-Endocrinology

169

131

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Abbreviations: CRP, C-reactive protein; CXCL9, CXC chemokine ligand 9; E-selectin, ESR, erythrocyte sedimentation rate, F1C2, prothrombin fragment 1C2; IFG, impaired fasting glucose; IL, interleukin; MCP-1, monocyte chemoattractant protein-1; NGAL, neutrophil gelatinase-associated lipocalin; NGT, normal glucose tolerance; ns, not stated; PAI-1, plasminogen activator inhibitor-1; sICAM-1, soluble intracellular adhesion molecule-1; sTNF-R2, soluble tumor necrosis factor a receptor type 2; TAT, thrombin antithrombin complex; TGF-b, transforming growth factor-b; TNF-a, tumor necrosis factor-a Seventeen found significantly reduced inflammatory markers, 19 did not, one was mixed and one showed adverse results. With few exceptions, studies in normal subjects, obesity, type 2 diabetics, and stable cardiovascular disease did not find significant beneficial effects. However, we found that 6 out of 7 RCTS of vitamin D 3 in highly inflammatory conditions (acute infantile congestive heart failure, multiple sclerosis, inflammatory bowel disease, cystic fibrosis, SLE, active TB and evolving myocardial infarction) found significant reductions. We found baseline and final 25(OH)D predicted RCTs with significant reduction in inflammatory markers. Vitamin D tends to modestly lower markers of inflammation in highly inflammatory conditions, when baseline 25(OH)D levels were low and when achieved 25(OH)D levels were higher. Future inquiries should: recruit subjects with low baseline 25(OH)D levels, subjects with elevated markers of inflammation, subjects with inflammatory conditions, achieve adequate final 25(OH)D levels, and use physiological doses of vitamin D. We attempted to identify all extant randomized controlled trials (RCTs) of vitamin D that used inflammatory markers as primary or secondary endpoints.

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Higher Serum 25-Hydroxyvitamin D Concentrations Associate with a Faster Recovery of Skeletal Muscle Strength after Muscular Injury

Cited by 106 publications

References 90 publications

Vitamin D and Physical Activity

Vitamin D and Physical Activity

Muscular effects of vitamin D in young athletes and non-athletes and in the elderly

Vitamin D and inflammation

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