Higher ratio of triglyceride to high-density lipoprotein cholesterol may predispose to diabetes mellitus: 15-year prospective study in a general population

Utility of the Triglyceride Level for Predicting Incident Diabetes Mellitus According to the Fasting Status and Body Mass Index Category: The Ibaraki Prefectural Health Study

“…For example, Hadaegh et al showed the TG, TG/HDL-C and TC/HDL-C levels to be independent predictors of incident DM in both fasting men and women in an Iranian cohort . Similar results were reported by He et al in that the TG and TG/HDLC levels were found to be independent predictors of incident DM in Chinese subjects in a fasting state 15) . However, the authors did not separate men and non-fasting women.…”

“…A limited number of studies have been performed to evaluate the effects of lipids on the incidence of DM 7,8,15) . For example, Hadaegh et al showed the TG, TG/HDL-C and TC/HDL-C levels to be independent predictors of incident DM in both fasting men and women in an Iranian cohort .…”

“…Therefore, our results are reasonable, given the findings of previous epidemiological studies 3,4,25,26) . The effect of TG on the risk of DM has been examined [7][8][9][10][11][12][13][14][15] . An impaired insulin function, consisting of insulin resistance and β-cell damage, is a characteristic feature of incident DM 16) .…”

“…Therefore, other mechanisms, such as impaired insulin secretion, have been proposed to account for the development of DM 20,21,38,39) . In our study, the women in their analysis 7,15) . In our study, the TG and TG/HDLC levels were identified to be significantly associated with incident DM in fasting men, whereas the TG/HDLC values were found to be significantly associated with incident DM in fasting women only after multivariate adjustment.…”

“…Among these parameters, triglycerides (TG), which are particularly influenced by insulin resistance 6) , represent an independent risk factor for DM [7][8][9][10][11][12][13][14][15] . Lipotoxicity, which results from the accumulation of lipids in the skeletal muscle, liver and pancreas, plays an important role in the onset of insulin resistance and β-cell damage 16,17) .…”